The role of first-trimester NLR (neutrophil to lymphocyte ratio), systemic immune-inflammation index (SII), and, systemic immune-response index (SIRI) in the prediction of composite adverse outcomes in pregnant women with systemic lupus erythematosus

Journal of Reproductive Immunology, Год журнала: 2023, Номер 158, С. 103978 - 103978

Опубликована: Июнь 12, 2023

Язык: Английский

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Second‐Trimester Inflammatory Markers in Predicting Fetal Growth Restriction: A Retrospective Analysis

American Journal of Reproductive Immunology, Год журнала: 2025, Номер 93(1)

Опубликована: Янв. 1, 2025

Fetal growth restriction (FGR) is a critical pregnancy complication linked to increased perinatal morbidity and mortality. Inflammation plays key role in FGR's pathophysiology, systemic inflammation markers may serve as predictors. This study evaluates the of various indices; immune-inflammation index (SII), inflammatory response (SIRI), pan-immune-inflammation value (PIV), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), monocyte-to-lymphocyte (MLR), lymphocyte-to-platelet (LMR), monocyte-to-platelet (MPR), aggregate (AISI), coagulation (SCII), immature granulocyte percentage (IG%) predicting FGR. retrospective included 403 pregnant women treated at Ankara Etlik City Hospital between August 2022 May 2024. The population comprised 202 with uncomplicated pregnancies (control group) 201 diagnosed FGR per Delphi Consensus Criteria. Second-trimester blood samples were used calculate indices. SII NLR levels significantly higher group compared controls (p = 0.020, p 0.028, respectively). However, no significant associations found these indices adverse neonatal outcomes. Cut-off values for 896 3.91, respectively, moderate sensitivity specificity. NLR, measured second trimester, be useful Although did not correlate outcomes, further prospective studies larger populations are needed validate their clinical utility.

Язык: Английский

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Pregnancy and delivery outcomes in coronavirus disease 2019: a cross-sectional study from a tertiary center

Revista da Associação Médica Brasileira, Год журнала: 2025, Номер 71(1)

Опубликована: Янв. 1, 2025

SUMMARY OBJECTIVE: The objective of this study was to document the clinical and laboratory characteristics maternal delivery outcomes pregnant women with coronavirus disease 2019. METHODS: We retrospectively assessed who had been admitted either symptoms 2019 or for from March 2020 January 2023. participants were evaluated in two cohorts: initial cohort included all hospitalized 2019, final those delivered under circumstances RESULTS: 295 symptomless (n=124, 42%), mild (n=122, 41.4%), moderate (n=18, 6.1%), severe (n=31, 10.5%) Among comorbidities, hypothyroidism (n=40, 13.6%) highest share. most frequent abnormality elevated D-dimer levels (94.6%). 193 women. Eight patients (4.1%) required intensive care unit (ICU) stay. Mortality occurred five (2.6%). Out 121 cesarean section (SC) deliveries, 61.2% on an emergency basis. Rates preterm, low birth weight, stillbirth 18.7%, 14.5%, 3.1%, respectively. Moderate-severe showed significant inverse correlations week, APGAR scores at 1 5 min (p<0.0001). CONCLUSION: A considerable proportion experienced complications, particularly preterm weight. Hypothyroidism a notable share among comorbidities.

Язык: Английский

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Predictive Value of First‐Trimester Aggregate Index of Systemic Inflammation (AISI) and Other Inflammatory Indices for Gestational Diabetes Mellitus and Associated Obstetric Outcomes

American Journal of Reproductive Immunology, Год журнала: 2025, Номер 93(4)

Опубликована: Апрель 1, 2025

To investigate the value of first-trimester aggregate index systemic inflammation (AISI) and other combined inflammatory markers in prediction gestational diabetes mellitus (GDM) related obstetric outcomes. The data pregnant women diagnosed with GDM between September 2021 November 2024, as well an equal number control patients, were retrospectively analyzed. patients' AISI, neutrophil lymphocyte ratio (NLR), immune-inflammatory (SII), response (SIRI) values calculated from hemogram parameters participants at 11-14 weeks gestation. clinical characteristics, laboratory results, indices, outcomes, need for neonatal intensive care unit (NICU) admission, presence composite adverse perinatal outcome (CAPO) groups then compared. Receiver operating characteristic (ROC) curve analyses performed to indices that reached statistical significance predicting GDM. group exhibited significantly higher SII AISI values, rate NICU CAPO compared (p = 0.036, p 0.011, < 0.01, respectively). age birth was lower group, while weight ROC yielded area under (AUC) 0.566 0.581 prediction, respectively 0.036 First-trimester may be useful identifying pregnancies high risk developing

Язык: Английский

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The impact of gestational weeks of Coronavirus disease 2019 (COVID-19) infection on perinatal outcomes

Reproductive Health, Год журнала: 2024, Номер 21(1)

Опубликована: Март 4, 2024

Abstract Background To evaluate the relationship between coronavirus disease 2019 (COVID-19) infection at different time points during pregnancy and perinatal outcomes. Methods This retrospective study included 611 women who hospitalized for delivery December 7 April 30, 2023. Based on weeks infected with COVID-19, participants were divided into four groups: Group 1 (14–27 +6 gestation), 2 (28–36 3 (37–39 4 (≥ 40 gestation). Data including maternal demographic characteristics, clinical profiles, outcomes analyzed. Results There no significant differences in characteristics among groups ( P > 0.05). Compared to Groups 4, a higher rate of fever was noted < The frequency preeclampsia gestational diabetes mellitus showed decreasing trend as progressing Preterm neonatal intensive care unit admission more frequently observed than Multivariate logistic regression analysis demonstrated that timing gestation which COVID-19 not associated preterm 0.05), whereas age negatively occurrence Conclusions Gestational is simple parameter predicts adverse aid clinicians determining provide early enhanced prenatal increased monitoring reduce complications.

Язык: Английский

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Clinical and laboratory characteristics of COVID-19 in pregnant women

Journal of Medicine and Life, Год журнала: 2023, Номер 16(5), С. 766 - 772

Опубликована: Май 1, 2023

This article discusses the distinct characteristics of COVID-19 in pregnant women and investigates potential early predictors disease severity this specific patient population.The study included 116 with a confirmed diagnosis different trimesters pregnancy.In addition to clinical features, we evaluated general research methods, biochemical parameters (procalcitonin, C-reactive protein, D-dimer), leukocyte index endogenous intoxication lymphocytic identify severity.All were divided into two groups: Group I -pregnant mild course, II moderate severe course COVID-19.Most (72.4%) experienced non-severe characterized by catarrhal symptoms intoxication.However, pulmonary manifestations pregnancy-related complications detected from 2. The levels protein procalcitonin both groups significantly increased compared control group.In COVID-19, indicators pronounced.Establishing associations between indices biomarkers, such as enables utilization routine complete blood counts primary screening tool for predicting women.

Язык: Английский

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Systemic Inflammation Response Index as a diagnostic and prognostic predictor of intrahepatic cholestasis of pregnancy: A case–control study from a tertiary center

International Journal of Gynecology & Obstetrics, Год журнала: 2023, Номер 165(2), С. 717 - 722

Опубликована: Ноя. 3, 2023

Язык: Английский

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Inflammatory Markers in Neonates Born to Mothers With SARS-CoV-2 Infection During Pregnancy

Опубликована: Янв. 9, 2024

The COVID-19 pandemic has raised concerns about its impact on maternal and neonatal health. This study aimed to investigate the influence of infection during pregnancy inflammatory parameters. A retrospective cohort was conducted at Premiere Hospital in Timisoara between May 2021 January 2022. Participants were categorized into two groups: positive group, consisting patients with confirmed SARS-CoV-2 in-fection pregnancy, control which comprised COVID-19-free pregnant women. primary outcome assessment markers (NLR, dNLR, PLR, SII) neonates born mothers COVID-19. results suggest that significantly impacts certain Spe-cifically, newborns exposed exhibited elevated white blood cell counts, particularly when occurred first trimester. Lymphocyte counts dimin-ished COVID-19-positive mothers, irrespective Gesta-tional age played a role altering immune profiles, correlations observed GA parameters Control Group (COVID-19 negative pregnancy). However, immunoreactivity laboratory remained generally non-significant after adjusting for In conclusion, discernible parameters, in-cluding WBC lymphocyte may have clinical implications.

Язык: Английский

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COVID-19 in Pregnancy: Influence of Body Weight and Nutritional Status on Maternal and Pregnancy Outcomes—A Review of Literature and Meta-Analysis

Nutrients, Год журнала: 2023, Номер 15(4), С. 1052 - 1052

Опубликована: Фев. 20, 2023

In the last two and a half years, COVID-19 has been one of most challenging public health issues worldwide. Based on available evidence, pregnant women do not appear to be more susceptible infection than general population but having during pregnancy may increase risk major complications for both mother fetus. The aim this study is identify correlation between BMI nutritional status likelihood contracting in pregnancy, its severity, maternal outcomes. We carry out systematic literature search meta-analysis using three databases following guidelines Cochrane Collaboration. include 45 studies about COVID-19-positive women. Compared with normal-weight COVID-19, obesity associated severe (OR = 2.32 [1.65–3.25]), increased death 2.84 [2.01–4.02]), higher rate hospital admission 2.11 [1.37–3.26]). Obesity adverse outcomes by increasing symptom severity and, consequently, Intensive Care Unit (ICU) admission, finally, rates. For micronutrients, results are less definite, even if there seems lower level particular Vitamin D,

Язык: Английский

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The Influence of Climate on Critically Ill Pregnant COVID-19 Patients, as Revealed by the Inflammation Indexes, in Spring versus Autumn 2021 Infection

Balneo and PRM Research Journal, Год журнала: 2023, Номер Vol.14, no.3, С. 571 - 571

Опубликована: Сен. 1, 2023

: (1) Background: Seasonality is an important environmental factor that influences immune responses (2) Methods: In a retrospective study, we included all pregnant patients admitted to the Elena Doamna Obstetrics and Gynecology Hospital with critical form of COVID-19 infection between 1 January December 2021. The blood counts collected on specific A, H E Brixia score- collection days, or ones closest those were considered in our study. We also studied differences two groups regarding inflammation indexes exhibited days: A (admittance), (highest score), (end hospitalization). (3) Results: values NLR, dNLR, SII, AISI are significantly higher IIC lower for spring group versus autumn group, especially score-collection days. (4) Conclusions: These results suggest severe-COVID-19 was 2021 Romania than 2021, regard patients.

Язык: Английский

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