Major depressive disorder

Nature Reviews Disease Primers, Год журнала: 2023, Номер 9(1)

Опубликована: Авг. 24, 2023

Язык: Английский

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Post-COVID-19 Depressive Symptoms: Epidemiology, Pathophysiology, and Pharmacological Treatment

CNS Drugs, Год журнала: 2022, Номер 36(7), С. 681 - 702

Опубликована: Июнь 21, 2022

Язык: Английский

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Clinical guidelines for the use of lifestyle-based mental health care in major depressive disorder: World Federation of Societies for Biological Psychiatry (WFSBP) and Australasian Society of Lifestyle Medicine (ASLM) taskforce

The World Journal of Biological Psychiatry, Год журнала: 2022, Номер 24(5), С. 333 - 386

Опубликована: Окт. 6, 2022

Objectives The primary objectives of these international guidelines were to provide a global audience clinicians with (a) series evidence-based recommendations for the provision lifestyle-based mental health care in clinical practice adults Major Depressive Disorder (MDD) and (b) implementation considerations that may be applicable across range settings.Methods Recommendations associated gradings based on systematic literature searches published research as well expertise taskforce members. focus was eight lifestyle domains: physical activity exercise, smoking cessation, work-directed interventions, mindfulness-based stress management therapies, diet, sleep, loneliness social support, green space interaction. following electronic bibliographic databases searched articles prior June 2020: PubMed, EMBASE, Cochrane Library (Cochrane Database Systematic Reviews, Central Register Controlled Trials (CENTRAL), Methodology Register), CINAHL, PsycINFO. Evidence grading level evidence specific MDD risk bias, accordance World Federation Societies Biological Psychiatry criteria.Results Nine formed. highest ratings improve use relaxation techniques, therapies (Grade 2). Interventions related diet recommended, but lower strength 3). regarding cessation support expert opinion. Key included need input from allied professionals networks implement this type approach, importance partnering such behaviour change deliver interventions using biopsychosocial-cultural framework.Conclusions Lifestyle-based are recommended foundational component Disorder, where other can added or used combination. findings further address existing gaps efficacy research, especially emerging approaches (e.g. space, interventions) data limited. Further work is also needed develop innovative delivery models care, training care.

Язык: Английский

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Management of Depression in Adults

JAMA, Год журнала: 2024, Номер 332(2), С. 141 - 141

Опубликована: Июнь 10, 2024

Importance Approximately 9% of US adults experience major depression each year, with a lifetime prevalence approximately 17% for men and 30% women. Observations Major is defined by depressed mood, loss interest in activities, associated psychological somatic symptoms lasting at least 2 weeks. Evaluation should include structured assessment severity as well risk self-harm, suspected bipolar disorder, psychotic symptoms, substance use, co-occurring anxiety disorder. First-line treatments specific psychotherapies antidepressant medications. A network meta-analysis randomized clinical trials reported cognitive therapy, behavioral activation, problem-solving interpersonal brief psychodynamic mindfulness-based psychotherapy all had medium-sized effects symptom improvement over usual care without (standardized mean difference [SMD] ranging from 0.50 [95% CI, 0.20-0.81] to 0.73 0.52-0.95]). 21 medications small- placebo (SMD 0.23 0.19-0.28] fluoxetine 0.48 0.41-0.55] amitriptyline). Psychotherapy combined medication may be preferred, especially more severe or chronic depression. greater treatment than alone (SMD, 0.30 0.14-0.45]) 0.33 0.20-0.47]). When initial not effective, second-line includes changing medication, adding second antidepressant, augmenting nonantidepressant which have equal likelihood success based on meta-analysis. Collaborative programs, including systematic follow-up outcome assessment, improve effectiveness, 1 reporting significantly compared 0.42 0.23-0.61]). Conclusions Relevance Effective first-line forms 20 Close monitoring improves the success.

Язык: Английский

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Probiotic, prebiotic, synbiotic and fermented food supplementation in psychiatric disorders: A systematic review of clinical trials

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 158, С. 105561 - 105561

Опубликована: Янв. 26, 2024

The use of probiotics, prebiotics, synbiotics or fermented foods can modulate the gut-brain axis and constitute a potentially therapeutic intervention in psychiatric disorders. This systematic review aims to identify current evidence regarding these interventions treatment patients with DSM/ICD diagnoses. Forty-seven articles from 42 studies met inclusion criteria. Risk bias was assessed all included studies. Major depression most studied disorder (n=19 studies). Studies frequently focused on schizophrenia (n=11) bipolar (n=5) there were limited anorexia nervosa (n=4), ADHD (n=3), Tourette (n=1), insomnia PTSD (n=1) generalized anxiety (n=1). Except MDD, does not clarify role probiotics prebiotics mental illness. Several point an improvement immune inflammatory profile (e.g. CRP, IL6), which may be relevant mechanism action response identified Future research should consider lifestyle dietary habits as possible confounders that influence inter-individual response.

Язык: Английский

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Diet and depression: A systematic review of whole dietary interventions as treatment in patients with depression

Journal of Affective Disorders, Год журнала: 2023, Номер 327, С. 270 - 278

Опубликована: Фев. 3, 2023

Язык: Английский

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Alleviating anxiety and taming trauma: Novel pharmacotherapeutics for anxiety disorders and posttraumatic stress disorder

Neuropharmacology, Год журнала: 2023, Номер 226, С. 109418 - 109418

Опубликована: Янв. 6, 2023

Psychiatric disorders associated with psychological trauma, stress and anxiety are a highly prevalent increasing cause of morbidity worldwide. Current therapeutic approaches, including medication, effective in alleviating symptoms posttraumatic disorder (PTSD), at least some individuals, but have unwanted side-effects do not resolve underlying pathophysiology. After period stagnation, there is renewed enthusiasm from public, academic commercial parties designing developing drug treatments for these disorders. Here, we aim to provide snapshot the current state this field that written neuropharmacologists, also practicing clinicians interested lay-reader. introducing currently available treatments, summarize recent/ongoing clinical assessment novel medicines PTSD, grouped according primary neurochemical targets their potential produce acute and/or enduring effects. The evaluation putative targeting monoamine (including psychedelics), GABA, glutamate, cannabinoid, cholinergic neuropeptide systems, amongst others, discussed. We emphasize importance clinically assessing new medications based on firm understanding neurobiology stemming rapid advances being made neuroscience. This includes harnessing neuroplasticity bring about lasting beneficial changes brain rather than – as many transient attenuation symptoms, exemplified by combining psychotropic/cognitive enhancing drugs psychotherapeutic approaches. conclude noting other emerging trends promising phase development.

Язык: Английский

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Major depressive disorder as a neuro-immune disorder: Origin, mechanisms, and therapeutic opportunities

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 155, С. 105425 - 105425

Опубликована: Окт. 16, 2023

Язык: Английский

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Treatment of Mood and Depressive Disorders With Complementary and Alternative Medicine: Efficacy Review

Journal of Midwifery & Women s Health, Год журнала: 2023, Номер 68(4), С. 421 - 429

Опубликована: Июнь 24, 2023

Abstract There has been a steady increase in people with symptoms of depression over the past several years (since 2011). The further stress and early part COVID‐19 pandemic was accompanied by an unmet mental health needs. Many have turned to complementary alternative medicine (CAM) therapies such as bright‐light therapy, yoga, meditation, dietary supplements like St. John's wort or folic acid. reliability evidence for use CAM remained low. are few randomized controlled trials (RCTs) current literature poor methodology many that available. This state science review examines published guidelines, meta‐analyses, systematic reviews, RCTs regarding management depression.

Язык: Английский

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Folate and Its Significance in Depressive Disorders and Suicidality: A Comprehensive Narrative Review

Nutrients, Год журнала: 2023, Номер 15(17), С. 3859 - 3859

Опубликована: Сен. 4, 2023

Depressive disorders pose significant challenges to global public health, necessitating effective prevention and management strategies. Notably, the occurrence of suicide frequently coincides with depressive episodes. Suicide is as a paramount health concern that demands efficacious preventive Current psychiatric approaches heavily rely on pharmacological interventions but have had limited success in addressing burden mental issues. Suboptimal nutrition, its impact neuroendocrine system, has been implicated underlying pathology disorders. Folate, group water-soluble compounds, plays crucial role various central nervous system functions. Depressed individuals often exhibit low levels serum red blood cell folate. Multiple studies systematic reviews investigated efficacy folic acid derivative, L-methylfolate, which can cross blood–brain barrier, stand-alone or adjunct therapies for depression. Although findings mixed, available evidence generally supports use these compounds depressed individuals. Recent established links between one-carbon cycle, folate–homocysteine balance, immune function, glutamate excitation via NMDA (N-methyl-D-aspartate) receptors, gut microbiome eubiosis mood regulation. These provide insights into complex neurobiological mechanisms effects folate related Through comprehensive review existing literature, this study aims advance our understanding therapeutic potential depression treatment. It also seeks explore their suicidal tendencies shed light involved, leveraging latest discoveries research.

Язык: Английский

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