The
epidemic
of
coronavirus
disease-19
(COVID-19)
has
grown
to
be
a
global
health
threat.
Gastrointestinal
symptoms
are
thought
common
clinical
manifestations
apart
from
series
originally
found
respiratory
symptoms.
human
gut
harbors
trillions
microorganisms
that
indispensable
for
complex
physiological
processes
and
homeostasis.
Growing
evidence
demonstrate
microbiota
alteration
is
associated
with
COVID-19
progress
severity,
post-COVID-19
syndrome,
characterized
by
decrease
anti-inflammatory
bacteria
like
Bifidobacterium
Faecalibacterium
enrichment
inflammation-associated
including
Streptococcus
Actinomyces.
Therapeutic
strategies
such
as
diet,
probiotics/prebiotics,
herb,
fecal
transplantation
have
shown
positive
effects
on
relieving
In
this
article,
we
provide
summarize
the
recent
about
their
metabolites
alterations
during
after
infection
focus
potential
therapeutic
targeting
microbiota.
Understanding
connections
between
intestinal
would
new
insights
into
management
in
future.
Microorganisms,
Год журнала:
2024,
Номер
12(2), С. 234 - 234
Опубликована: Янв. 23, 2024
Probiotics,
known
to
be
live
microorganisms,
have
been
shown
improve
or
restore
the
gut
microbiota,
which
in
turn
has
linked
improved
health.
It
is
believed
that
probiotics
are
modern
equivalent
of
a
panacea,
with
claims
they
may
treat
prevent
different
diseases
both
children
and
adults
(e.g.,
from
colic
babies
cardiovascular
disease,
respiratory
infection,
cancer
adults).
Ever
since
early
2000s,
probiotic-based
fermented
foods
had
resurgence
popularity,
mostly
due
made
regarding
their
health
benefits.
Fermented
associated
prevention
irritable
bowel
syndrome,
lactose
intolerance,
gastroenteritis,
obesity,
but
also
other
conditions
such
as
chronic
diarrhea,
allergies,
dermatitis,
bacterial
viral
infections,
all
closely
related
an
unhealthy
lifestyle.
Recent
ongoing
developments
microbiome/microbiota
science
given
us
new
research
directions
for
probiotics.
The
types,
mechanisms,
applications
studied
so
far,
those
currently
under
study,
great
potential
change
scientific
understanding
probiotics’
nutritional
human
care.
expansion
fields
study
microbiome
involvement
its
improvement
foreshadow
era
significant
changes.
An
expanding
range
candidate
probiotic
species
emerging
can
address
newly
elucidated
data-driven
microbial
niches
host
targets.
In
field,
variants
microbiome-modulating
interventions
being
developed,
including
prebiotics,
symbiotics,
postbiotics,
consortia,
biotherapeutic
products,
genetically
modified
organisms,
renewed
interest
polyphenols,
fibers,
ensure
This
manuscript
aims
analyze
recent,
emerging,
anticipated
trends
(sources,
doses,
mechanism
action,
administered,
side
effects,
risks)
create
vision
development
areas
influence
field.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Май 31, 2022
Respiratory
diseases
cause
a
high
incidence
and
mortality
worldwide.
As
natural
immunobiotic,
Lactobacillus
has
excellent
immunomodulatory
ability.
Administration
of
some
species
can
alleviate
the
symptoms
respiratory
such
as
tract
infections,
asthma,
lung
cancer
cystic
fibrosis
in
animal
studies
clinical
trials.
The
beneficial
effect
on
is
strain
dependent.
Moreover,
efficacy
may
be
affected
by
many
factors,
bacteria
dose,
timing
host
background.
Here,
we
summarized
administered
common
with
focus
mechanism
safety
regulating
immunity.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 5, 2024
The
imbalance
of
microbial
composition
and
diversity
in
favor
pathogenic
microorganisms
combined
with
a
loss
beneficial
gut
microbiota
taxa
results
from
factors
such
as
age,
diet,
antimicrobial
administration
for
different
infections,
other
underlying
medical
conditions,
etc.
Probiotics
are
known
their
capacity
to
improve
health
by
stimulating
the
indigenous
microbiota,
enhancing
host
immunity
resistance
infection,
helping
digestion,
carrying
out
various
functions.
Concurrently,
metabolites
produced
these
microorganisms,
termed
postbiotics,
which
include
compounds
like
bacteriocins,
lactic
acid,
hydrogen
peroxide,
contribute
inhibiting
wide
range
bacteria.
This
review
presents
an
update
on
using
probiotics
managing
treating
human
diseases,
including
complications
that
may
emerge
during
or
after
COVID-19
infection.
Food Bioengineering,
Год журнала:
2024,
Номер
3(1), С. 41 - 64
Опубликована: Март 1, 2024
Abstract
Probiotics
have
become
increasingly
popular
over
the
past
two
decades
due
to
continuously
expanding
scientific
evidence
indicating
their
beneficial
effects
on
human
health.
Therefore,
they
been
applied
in
food
industry
produce
functional
food,
which
plays
a
significant
role
health
and
reduces
disease
risk.
However,
maintaining
viability
of
probiotics
targeting
successful
delivery
gastrointestinal
tract
remain
challenging
tasks
applications.
Specifically,
this
paper
reviews
potentially
properties
probiotics,
highlighting
use
challenges
application
associated
benefits.
Of
foremost
importance,
also
explores
potential
underlying
molecular
mechanisms
enhanced
effect
epithelial
cells,
including
discussion
various
surface
adhesion‐related
proteins
probiotic
cell
that
facilitate
colonization.
Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Янв. 7, 2025
Abstract
The
mucosal
immune
system,
as
the
most
extensive
peripheral
network,
serves
frontline
defense
against
a
myriad
of
microbial
and
dietary
antigens.
It
is
crucial
in
preventing
pathogen
invasion
establishing
tolerance.
A
comprehensive
understanding
immunity
essential
for
developing
treatments
that
can
effectively
target
diseases
at
their
entry
points,
thereby
minimizing
overall
impact
on
body.
Despite
its
importance,
our
knowledge
remains
incomplete,
necessitating
further
research.
outbreak
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
has
underscored
critical
role
disease
prevention
treatment.
This
systematic
review
focuses
dynamic
interactions
between
mucosa-associated
lymphoid
structures
related
diseases.
We
delve
into
basic
functions
these
tissues
during
processes
explore
intricate
regulatory
networks
mechanisms
involved.
Additionally,
we
summarize
novel
therapies
clinical
research
advances
immunity-related
also
addresses
challenges
vaccines,
which
aim
to
induce
specific
responses
while
maintaining
tolerance
non-pathogenic
microbes.
Innovative
therapies,
such
nanoparticle
vaccines
inhalable
antibodies,
show
promise
enhancing
offer
potential
improved
Biomolecules,
Год журнала:
2022,
Номер
12(10), С. 1442 - 1442
Опубликована: Окт. 9, 2022
Infectious
diseases
have
been
a
threat
to
human
health
globally.
The
relentless
efforts
and
research
enabled
us
overcome
most
of
the
through
use
antiviral
antibiotic
agents
discovered
employed.
Unfortunately,
microorganisms
capability
adapt
mutate
over
time
resistance
ensues.
There
are
many
challenges
in
treating
infections
such
as
failure
respond
therapeutic
agents,
which
has
led
more
chronic
infections,
complications,
preventable
loss
life.
Thus,
multidisciplinary
approach
collaboration
is
warranted
create
potent,
effective,
versatile
therapies
prevent
eradicate
old
newly
emerging
diseases.
In
recent
past,
natural
medicine
proven
its
effectiveness
against
various
illnesses.
Most
pharmaceutical
currently
used
can
trace
their
origin
products
one
way,
shape,
or
form.
full
potential
yet
be
realized,
numerous
resources
not
explored
analyzed.
This
merits
continuous
support
analysis
ancient
treatment
systems
explore
employ
them
an
alternative
principal
therapy.
Frontiers in Microbiology,
Год журнала:
2022,
Номер
13
Опубликована: Авг. 12, 2022
The
coronavirus
disease
2019
(COVID-19)
is
an
infectious
caused
by
severe
acute
respiratory
syndrome
2
(SARS-CoV-2).
According
to
the
World
Health
Organization
statistics,
more
than
500
million
individuals
have
been
infected
and
6
deaths
resulted
worldwide.
Although
COVID-19
mainly
affects
system,
considerable
evidence
shows
that
digestive,
cardiovascular,
nervous,
reproductive
systems
can
all
be
involved.
Angiotensin-converting
enzyme
(AEC2),
target
of
SARS-CoV-2
invasion
host
distributed
in
gastrointestinal
tract.
Studies
found
microbiota
contributes
onset
progression
many
diseases,
including
COVID-19.
Here,
we
firstly
conclude
characterization
respiratory,
gut,
oral
microbial
dysbiosis,
bacteria,
fungi,
viruses.
Then
explore
potential
mechanisms
involvement
Microbial
dysbiosis
could
influence
complex
interactions
with
immunity.
Moreover,
may
impact
on
through
their
metabolites
or
modulation
ACE2
expression.
Subsequently,
generalize
as
diagnostic
markers
for
patients
its
possible
association
post-acute
(PACS)
relapse
after
recovery.
Finally,
proposed
directed
microbiota-targeted
treatments
from
perspective
gut
microecology
such
probiotics
prebiotics,
fecal
transplantation
antibiotics,
other
interventions
traditional
Chinese
medicine,
vaccines,
ACE2-based
treatments.
Molecular Psychiatry,
Год журнала:
2023,
Номер
28(12), С. 4968 - 4976
Опубликована: Июль 4, 2023
The
coronavirus
disease
2019
(COVID-19)
pandemic
caused
by
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
infection
has
resulted
in
a
serious
public
health
burden
worldwide.
In
addition
to
respiratory,
heart,
and
gastrointestinal
symptoms,
patients
infected
with
SARS-CoV-2
experience
number
of
persistent
neurological
psychiatric
known
as
long
COVID
or
"brain
fog".
Studies
autopsy
samples
from
who
died
COVID-19
detected
the
brain.
Furthermore,
increasing
evidence
shows
that
Epstein-Barr
virus
(EBV)
reactivation
after
might
play
role
symptoms.
Moreover,
alterations
microbiome
contribute
this
article,
author
reviews
detrimental
effects
on
brain,
biological
mechanisms
(e.g.,
EBV
reactivation,
changes
gut,
nasal,
oral,
lung
microbiomes)
underlying
COVID.
addition,
discusses
potential
therapeutic
approaches
based
gut-brain
axis,
including
plant-based
diet,
probiotics
prebiotics,
fecal
microbiota
transplantation,
vagus
nerve
stimulation,
sigma-1
receptor
agonist
fluvoxamine.
