Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2022, Volume and Issue: 20(5), P. 323 - 337

Published: Oct. 21, 2022

Language: Английский

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The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties

Microorganisms, Journal Year: 2024, Volume and Issue: 12(2), P. 234 - 234

Published: Jan. 23, 2024

Probiotics, known to be live microorganisms, have been shown improve or restore the gut microbiota, which in turn has linked improved health. It is believed that probiotics are modern equivalent of a panacea, with claims they may treat prevent different diseases both children and adults (e.g., from colic babies cardiovascular disease, respiratory infection, cancer adults). Ever since early 2000s, probiotic-based fermented foods had resurgence popularity, mostly due made regarding their health benefits. Fermented associated prevention irritable bowel syndrome, lactose intolerance, gastroenteritis, obesity, but also other conditions such as chronic diarrhea, allergies, dermatitis, bacterial viral infections, all closely related an unhealthy lifestyle. Recent ongoing developments microbiome/microbiota science given us new research directions for probiotics. The types, mechanisms, applications studied so far, those currently under study, great potential change scientific understanding probiotics’ nutritional human care. expansion fields study microbiome involvement its improvement foreshadow era significant changes. An expanding range candidate probiotic species emerging can address newly elucidated data-driven microbial niches host targets. In field, variants microbiome-modulating interventions being developed, including prebiotics, symbiotics, postbiotics, consortia, biotherapeutic products, genetically modified organisms, renewed interest polyphenols, fibers, ensure This manuscript aims analyze recent, emerging, anticipated trends (sources, doses, mechanism action, administered, side effects, risks) create vision development areas influence field.

Language: Английский

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The Beneficial Role of Probiotic Lactobacillus in Respiratory Diseases

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: May 31, 2022

Respiratory diseases cause a high incidence and mortality worldwide. As natural immunobiotic, Lactobacillus has excellent immunomodulatory ability. Administration of some species can alleviate the symptoms respiratory such as tract infections, asthma, lung cancer cystic fibrosis in animal studies clinical trials. The beneficial effect on is strain dependent. Moreover, efficacy may be affected by many factors, bacteria dose, timing host background. Here, we summarized administered common with focus mechanism safety regulating immunity.

Language: Английский

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Introduction to Traditional Medicine and Their Role in Prevention and Treatment of Emerging and Re-Emerging Diseases

Biomolecules, Journal Year: 2022, Volume and Issue: 12(10), P. 1442 - 1442

Published: Oct. 9, 2022

Infectious diseases have been a threat to human health globally. The relentless efforts and research enabled us overcome most of the through use antiviral antibiotic agents discovered employed. Unfortunately, microorganisms capability adapt mutate over time resistance ensues. There are many challenges in treating infections such as failure respond therapeutic agents, which has led more chronic infections, complications, preventable loss life. Thus, multidisciplinary approach collaboration is warranted create potent, effective, versatile therapies prevent eradicate old newly emerging diseases. In recent past, natural medicine proven its effectiveness against various illnesses. Most pharmaceutical currently used can trace their origin products one way, shape, or form. full potential yet be realized, numerous resources not explored analyzed. This merits continuous support analysis ancient treatment systems explore employ them an alternative principal therapy.

Language: Английский

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Role of probiotics in managing various human diseases, from oral pathology to cancer and gastrointestinal diseases

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 5, 2024

The imbalance of microbial composition and diversity in favor pathogenic microorganisms combined with a loss beneficial gut microbiota taxa results from factors such as age, diet, antimicrobial administration for different infections, other underlying medical conditions, etc. Probiotics are known their capacity to improve health by stimulating the indigenous microbiota, enhancing host immunity resistance infection, helping digestion, carrying out various functions. Concurrently, metabolites produced these microorganisms, termed postbiotics, which include compounds like bacteriocins, lactic acid, hydrogen peroxide, contribute inhibiting wide range bacteria. This review presents an update on using probiotics managing treating human diseases, including complications that may emerge during or after COVID-19 infection.

Language: Английский

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Probiotics: Health benefits, food application, and colonization in the human gastrointestinal tract

Food Bioengineering, Journal Year: 2024, Volume and Issue: 3(1), P. 41 - 64

Published: March 1, 2024

Abstract Probiotics have become increasingly popular over the past two decades due to continuously expanding scientific evidence indicating their beneficial effects on human health. Therefore, they been applied in food industry produce functional food, which plays a significant role health and reduces disease risk. However, maintaining viability of probiotics targeting successful delivery gastrointestinal tract remain challenging tasks applications. Specifically, this paper reviews potentially properties probiotics, highlighting use challenges application associated benefits. Of foremost importance, also explores potential underlying molecular mechanisms enhanced effect epithelial cells, including discussion various surface adhesion‐related proteins probiotic cell that facilitate colonization.

Language: Английский

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Mucosal immune response in biology, disease prevention and treatment

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 7, 2025

Abstract The mucosal immune system, as the most extensive peripheral network, serves frontline defense against a myriad of microbial and dietary antigens. It is crucial in preventing pathogen invasion establishing tolerance. A comprehensive understanding immunity essential for developing treatments that can effectively target diseases at their entry points, thereby minimizing overall impact on body. Despite its importance, our knowledge remains incomplete, necessitating further research. outbreak severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has underscored critical role disease prevention treatment. This systematic review focuses dynamic interactions between mucosa-associated lymphoid structures related diseases. We delve into basic functions these tissues during processes explore intricate regulatory networks mechanisms involved. Additionally, we summarize novel therapies clinical research advances immunity-related also addresses challenges vaccines, which aim to induce specific responses while maintaining tolerance non-pathogenic microbes. Innovative therapies, such nanoparticle vaccines inhalable antibodies, show promise enhancing offer potential improved

Language: Английский

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Long COVID clinical evaluation, research and impact on society: a global expert consensus

Annals of Clinical Microbiology and Antimicrobials, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 20, 2025

Abstract Background Long COVID is a complex, heterogeneous syndrome affecting over four hundred million people globally. There are few recommendations, and no formal training exists for medical professionals to assist with clinical evaluation management of patients COVID. More research into the pathology, cellular, molecular mechanisms COVID, treatments needed. The goal this work disseminate essential information about recommendations definition, diagnosis, treatment, social issues physicians, researchers, policy makers address escalating global health crisis. Methods A 3-round modified Delphi consensus methodology was distributed internationally 179 healthcare professionals, persons lived experience in 28 countries. Statements were combined specific areas: research, society. Results survey resulted 187 comprehensive statements reaching strongest areas being diagnosis assessment, general research. We establish conditions different subgroups within umbrella. Clear reached that impacts COVID-19 infection on children should be priority, additionally need determine effects societies economies. it affects nervous system other organs not likely observed initial symptoms. note, biomarkers critically needed these issues. Conclusions This forms guidance spectrum as disease reinforces translational large-scale treatment trials protocols.

Language: Английский

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Microbiota and COVID-19: Long-term and complex influencing factors

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 12, 2022

The coronavirus disease 2019 (COVID-19) is an infectious caused by severe acute respiratory syndrome 2 (SARS-CoV-2). According to the World Health Organization statistics, more than 500 million individuals have been infected and 6 deaths resulted worldwide. Although COVID-19 mainly affects system, considerable evidence shows that digestive, cardiovascular, nervous, reproductive systems can all be involved. Angiotensin-converting enzyme (AEC2), target of SARS-CoV-2 invasion host distributed in gastrointestinal tract. Studies found microbiota contributes onset progression many diseases, including COVID-19. Here, we firstly conclude characterization respiratory, gut, oral microbial dysbiosis, bacteria, fungi, viruses. Then explore potential mechanisms involvement Microbial dysbiosis could influence complex interactions with immunity. Moreover, may impact on through their metabolites or modulation ACE2 expression. Subsequently, generalize as diagnostic markers for patients its possible association post-acute (PACS) relapse after recovery. Finally, proposed directed microbiota-targeted treatments from perspective gut microecology such probiotics prebiotics, fecal transplantation antibiotics, other interventions traditional Chinese medicine, vaccines, ACE2-based treatments.

Language: Английский

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Beneficial features of pediococcus: from starter cultures and inhibitory activities to probiotic benefits

World Journal of Microbiology and Biotechnology, Journal Year: 2022, Volume and Issue: 39(1)

Published: Nov. 8, 2022

Language: Английский

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