Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 17, 2024
Background
Alzheimer’s
disease
(AD)
is
a
neurodegenerative
characterized
by
progressive
decline
in
cognitive
function,
which
significantly
increases
pain
and
social
burden.
However,
few
therapeutic
interventions
are
effective
preventing
or
mitigating
the
progression
of
AD.
An
increasing
number
recent
studies
support
hypothesis
that
gut
microbiome
its
metabolites
may
be
associated
with
upstream
regulators
AD
pathology.
Methods
In
this
review,
we
comprehensively
explore
potential
mechanisms
currently
available
targeting
for
improvement
Our
discussion
structured
around
modern
research
advancements
AD,
bidirectional
communication
between
brain,
multi-target
regulatory
effects
microbial
on
strategies
aimed
at
modulating
microbiota
to
manage
Results
The
plays
crucial
role
pathogenesis
through
continuous
via
microbiota-gut-brain
axis.
Among
these,
such
as
lipids,
amino
acids,
bile
acids
neurotransmitters,
especially
sphingolipids
phospholipids,
serve
central
components
gut-brain
axis,
regulating
AD-related
pathogenic
including
β-amyloid
metabolism,
Tau
protein
phosphorylation,
neuroinflammation.
Additionally,
probiotic
administration,
fecal
transplantation,
antibiotic
use
have
also
provided
evidence
supporting
association
At
same
time,
propose
an
innovative
strategy
treating
AD:
healthy
lifestyle
combined
targeted
probiotics
other
interventions,
aiming
restore
intestinal
ecology
balance.
Conclusion
Despite
previous
efforts,
molecular
microbes
act
yet
fully
described.
microorganisms
become
essential
target
connecting
axis
improving
symptoms
it
requires
joint
exploration
multiple
centers
disciplines.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 14, 2024
Recent
studies
have
indicated
that
gut
microbiota-mediated
oxidative
stress
is
significantly
associated
with
intestinal
diseases
such
as
colorectal
cancer,
ulcerative
colitis,
and
Crohn’s
disease.
The
level
of
reactive
oxygen
species
(ROS)
has
been
reported
to
increase
when
the
microbiota
dysregulated,
especially
several
bacterial
metabolites
are
present.
Although
healthy
plays
a
vital
role
in
defending
against
excessive
stress,
disease
influenced
by
ROS,
this
process
controlled
immunological
responses,
DNA
damage,
inflammation.
In
review,
we
discuss
relationship
between
from
an
perspective.
addition,
also
provide
summary
most
recent
therapeutic
approaches
for
preventing
or
treating
modifying
microbiota.
Translational Neurodegeneration,
Год журнала:
2024,
Номер
13(1)
Опубликована: Фев. 27, 2024
The
aetiologies
and
origins
of
neurodegenerative
diseases,
such
as
Alzheimer's
disease
(AD),
Parkinson's
(PD),
amyotrophic
lateral
sclerosis
(ALS)
Huntington's
(HD),
are
complex
multifaceted.
A
growing
body
evidence
suggests
that
the
gut
microbiome
plays
crucial
roles
in
development
progression
diseases.
Clinicians
have
come
to
realize
therapeutics
targeting
potential
halt
This
narrative
review
examines
alterations
AD,
PD,
ALS
HD,
highlighting
close
relationship
between
brain
Processes
mediate
microbiome-brain
communication
including
immunological,
vagus
nerve
circulatory
pathways,
evaluated.
Furthermore,
we
summarize
for
diseases
modify
its
metabolites,
diets,
probiotics
prebiotics,
microbial
antibacterials
faecal
transplantation.
Finally,
current
challenges
future
directions
discussed.
Alzheimer's
disease
is
a
developing
public
health
concern
in
aging
communities
that
affects
sizable
section
of
the
global
population.
The
risk
increases
with
age;
it
one-third
males
and
two-thirds
women.
This
research
attempts
to
assess
effect
nano-selenium
thymoquinone
on
Nrf2
gene
expression
levels
(AD).
There
were
five
identical
groups
50
albino
male
rats:
control
group
was
healthy;
an
AD
positive
group;
received
(5
mg/kg);
(2
both.
duration
treatment
4
weeks.
brain
tissues
evaluated
using
real-time
PCR.
mean
nano-selenium-treated
rats,
thymoquinone-treated
rats
given
both
treatments
all
increased
significantly
compared
no
treatment.
study
showed
elevated
AD.
Antioxidants,
Год журнала:
2024,
Номер
13(7), С. 762 - 762
Опубликована: Июнь 24, 2024
Neurodegenerative
diseases
are
a
significant
challenge
to
global
healthcare,
and
oxidative
stress
plays
crucial
role
in
their
development.
This
paper
presents
comprehensive
analysis
of
the
neuroprotective
potential
olive
oil,
with
primary
focus
on
its
antioxidant
properties.
The
chemical
composition
including
key
antioxidants,
such
as
oleuropein,
hydroxytyrosol,
oleocanthal,
is
systematically
examined.
mechanisms
by
which
these
compounds
provide
neuroprotection,
counteracting
damage
modulating
pathways,
explored.
efficacy
oil
evaluated
synthesizing
findings
from
various
sources,
vitro
studies,
animal
models,
clinical
trials.
integration
into
dietary
patterns,
particularly
Mediterranean
diet,
broader
implications
neurodegenerative
disease
prevention
also
discussed.
challenges
translating
preclinical
applications
acknowledged
future
research
directions
proposed
better
understand
mitigating
risk
conditions.
review
highlights
not
only
component,
but
promising
candidate
preventive
neurology,
advocating
for
further
investigation
context
diseases.
Frontiers in Aging Neuroscience,
Год журнала:
2024,
Номер
16
Опубликована: Июль 3, 2024
As
the
most
common
cause
of
dementia,
Alzheimer’s
disease
(AD)
is
characterized
by
neurodegeneration
and
synaptic
loss
with
an
increasing
prevalence
in
elderly.
Increased
inflammatory
responses
triggers
brain
cells
to
produce
pro-inflammatory
cytokines
accelerates
Aβ
accumulation,
tau
protein
hyper-phosphorylation
leading
neurodegeneration.
Therefore,
this
paper,
we
discuss
current
understanding
how
inflammation
affects
activity
induce
AD
pathology,
biomarkers
possible
therapies
that
combat
for
AD.
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(7)
Опубликована: Июль 1, 2024
Abstract
Introduction
Alzheimer's
disease
(AD),
the
main
cause
of
dementia,
is
characterized
by
synaptic
loss
and
neurodegeneration.
Amyloid‐β
(Aβ)
accumulation,
hyperphosphorylation
tau
protein,
neurofibrillary
tangles
(NFTs)
in
brain
are
considered
to
be
initiating
factors
AD.
However,
this
hypothesis
falls
short
explaining
many
aspects
AD
pathogenesis.
Recently,
there
has
been
mounting
evidence
that
neuroinflammation
plays
a
key
role
pathophysiology
causes
neurodegeneration
over‐activating
microglia
releasing
inflammatory
mediators.
Methods
PubMed,
Web
Science,
EMBASE,
MEDLINE
were
used
for
searching
summarizing
all
recent
publications
related
inflammation
its
association
with
disease.
Results
Our
review
shows
how
dysregulation
influences
pathology
as
well
roles
neuroinflammation,
possible
microglia‐associated
therapeutic
targets,
top
neuroinflammatory
biomarkers,
anti‐inflammatory
drugs
combat
inflammation.
Conclusion
In
conclusion,
microglial
reactions
important
pathogenesis
need
discussed
more
detail
promising
strategies.
Microorganisms,
Год журнала:
2023,
Номер
11(10), С. 2550 - 2550
Опубликована: Окт. 13, 2023
The
accumulation
of
amyloid-beta
plaques
in
the
brain
is
a
central
pathological
feature
Alzheimer’s
disease.
It
believed
that
amyloid
responses
may
be
result
host
immune
response
to
pathogens
both
nervous
system
and
peripheral
systems.
Oral
microbial
dysbiosis
chronic
condition
affecting
more
than
50%
older
adults.
Recent
studies
have
linked
oral
higher
Aβ
load
development
disease
humans.
Moreover,
presence
an
oral-derived
predominant
microbiome
has
been
identified
brains
patients
with
other
neurodegenerative
diseases.
Therefore,
this
opinion
article,
we
aim
provide
summary
on
microbiomes
contribute
pathogenesis
