Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 17, 2024
Background
Alzheimer’s
disease
(AD)
is
a
neurodegenerative
characterized
by
progressive
decline
in
cognitive
function,
which
significantly
increases
pain
and
social
burden.
However,
few
therapeutic
interventions
are
effective
preventing
or
mitigating
the
progression
of
AD.
An
increasing
number
recent
studies
support
hypothesis
that
gut
microbiome
its
metabolites
may
be
associated
with
upstream
regulators
AD
pathology.
Methods
In
this
review,
we
comprehensively
explore
potential
mechanisms
currently
available
targeting
for
improvement
Our
discussion
structured
around
modern
research
advancements
AD,
bidirectional
communication
between
brain,
multi-target
regulatory
effects
microbial
on
strategies
aimed
at
modulating
microbiota
to
manage
Results
The
plays
crucial
role
pathogenesis
through
continuous
via
microbiota-gut-brain
axis.
Among
these,
such
as
lipids,
amino
acids,
bile
acids
neurotransmitters,
especially
sphingolipids
phospholipids,
serve
central
components
gut-brain
axis,
regulating
AD-related
pathogenic
including
β-amyloid
metabolism,
Tau
protein
phosphorylation,
neuroinflammation.
Additionally,
probiotic
administration,
fecal
transplantation,
antibiotic
use
have
also
provided
evidence
supporting
association
At
same
time,
propose
an
innovative
strategy
treating
AD:
healthy
lifestyle
combined
targeted
probiotics
other
interventions,
aiming
restore
intestinal
ecology
balance.
Conclusion
Despite
previous
efforts,
molecular
microbes
act
yet
fully
described.
microorganisms
become
essential
target
connecting
axis
improving
symptoms
it
requires
joint
exploration
multiple
centers
disciplines.
Frontiers in Aging Neuroscience,
Год журнала:
2024,
Номер
16
Опубликована: Авг. 21, 2024
Introduction
Alzheimer’s
disease
(AD),
a
major
cause
of
dementia
globally,
imposes
significant
societal
and
personal
costs.
This
review
explores
the
efficacy
physical
exercise
as
non-pharmacological
intervention
to
mitigate
impacts
AD.
Methods
draws
on
recent
studies
that
investigate
effects
neuroinflammation
neuronal
enhancement
in
individuals
with
Results
Consistent
alters
neuroinflammatory
pathways,
enhances
cognitive
functions,
bolsters
brain
health
among
AD
patients.
It
favorably
influences
activation
states
microglia
astrocytes,
fortifies
integrity
blood-brain
barrier,
attenuates
gut
inflammation
associated
These
changes
are
substantial
improvements
performance
indicators.
Discussion
The
findings
underscore
potential
integrating
into
comprehensive
management
strategies.
Emphasizing
necessity
for
further
research,
this
advocates
refinement
regimens
maximize
their
enduring
benefits
decelerating
progression
Journal of Alzheimer s Disease Reports,
Год журнала:
2025,
Номер
9
Опубликована: Янв. 1, 2025
The
association
between
gut
microbes
and
Alzheimer's
disease
(AD)
has
not
been
entirely
elucidated.
We
aimed
to
demonstrate
the
AD
further
investigate
pathogenesis
of
with
a
causal
relationship
AD.
Mendelian
randomization
analyses
were
used
determine
significant
Protein-protein
interaction
(PPI)
network
was
identify
hub
genes.
Functional
enrichment
analysis
reveal
theoretically
In
present
study,
total
32
identified
that
significantly
associated
Subsequently,
DLGAP2,
NRXN3,
NEGR1,
NTNAP2,
MYH9,
SCN3A
as
genes
NTNAP2
enriched
in
cell
adhesion
molecules
(CAMs)
signaling,
taxons
corresponded
these
Bifidobacterium
adolescentis,
Actinomycetales,
Intestinimonas
massiliensis.
massiliensis
may
promote
progression
through
regulation
CAMs
signaling
pathway-mediated
synaptic
function.
Hence,
in-depth
study
increase
efficiency
screening
diagnosis
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 3148 - 3148
Опубликована: Март 28, 2025
Oxidative
stress
(OS)
and
gut
microbiota
are
crucial
factors
influencing
human
health,
each
playing
a
significant
role
in
the
development
progression
of
chronic
diseases.
This
review
provides
comprehensive
analysis
complex
interplay
between
these
two
factors,
focusing
on
how
an
imbalance
reactive
oxygen
species
(ROS)
antioxidants
leads
to
OS,
disrupting
cellular
homeostasis
contributing
range
conditions,
including
metabolic
disorders,
cardiovascular
diseases,
neurological
cancer.
The
microbiota,
diverse
community
microorganisms
residing
gastrointestinal
tract,
is
essential
for
regulating
immune
responses,
pathways,
overall
health.
Dysbiosis,
composition,
closely
associated
with
inflammation,
dysfunction,
various
highlights
influences
influenced
by
complicating
pathophysiology
many
conditions.
Furthermore,
emerging
evidence
has
identified
extracellular
vesicles
(EVs)
as
critical
facilitators
crosstalk
OS
microbiota.
EVs
also
play
signaling
host
tissues,
modulating
processes.
function
holds
promise
targeted
therapies
aimed
at
restoring
microbial
balance
mitigating
OS.
Personalized
therapeutic
approaches,
probiotics,
antioxidants,
fecal
transplantation-based
strategies,
can
be
used
address
OS-related
diseases
improve
health
outcomes.
Nonetheless,
further
research
needed
study
molecular
mechanisms
underlying
interactions
potential
innovative
interventions
offer
novel
strategies
managing
enhancing
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 3340 - 3340
Опубликована: Апрель 3, 2025
In
this
review
article,
we
discuss
and
explore
the
role
of
bacteria-derived
hydrogen
sulfide.
Hydrogen
sulfide
is
a
signaling
molecule
produced
endogenously
that
plays
an
important
in
health
disease.
It
also
by
gut
microbiome.
setting
microbial
disturbances
leading
to
disruption
intestinal
homeostasis
(dysbiosis),
concentration
available
can
vary
pathologic
sequelae.
The
brain-gut
axis
original
studied
paradigm
microbiome
host
interaction.
recent
years,
our
understanding
interaction
has
expanded
greatly
include
specific
pathways
have
branched
into
their
own
axes.
These
axes
share
principal
concept
microbiota
changes,
permeability,
inflammatory
response,
some
which
are
modulated
(H2S).
review,
will
multiple
including
gut-immune,
gut-heart,
gut-endocrine
We
evaluate
H2S
modulation
barrier,
mucosal
healing
inflammation
tumor
genesis.
alpha-synuclein
aggregation
ischemic
injury.
Finally,
metabolic
syndrome
as
int
pertains
hypertension,
atherosclerosis
glucose-like
peptide-1
activity.
Majority
studies
focus
on
endogenous
production;
examine
lesser-known
source
progression
diseases
it
relates
these
The
gut-brain
axis
(GBA)
denotes
the
dynamic
and
bidirectional
communication
system
that
connects
gastrointestinal
tract
central
nervous
(CNS).
This
review
explored
this
axis,
focusing
on
role
of
microbial
diversity
fitness
in
maintaining
health
preventing
neurodegeneration,
particularly
Alzheimer's
disease
(AD).
Gut
dysbiosis,
characterized
by
imbalance
populations
beneficial
harmful
bacteria,
has
been
associated
with
increased
systemic
inflammation,
neuroinflammation,
progression
AD
through
pathogenic
mechanisms
involving
amyloid
deposition,
tauopathy,
blood-brain
barrier
(BBB)
permeability.
Emerging
evidence
highlighted
therapeutic
potential
probiotics,
dietary
interventions,
intermittent
fasting
restoring
balance,
reducing
minimizing
neurodegenerative
risks.
Probiotics
synbiotics
are
promising
helping
improve
cognitive
function
metabolic
health,
while
patterns
like
Mediterranean
diet
were
linked
to
decreased
neuroinflammation
enhanced
communication.
Despite
significant
advancement,
further
research
is
needed
elucidate
specific
strains,
metabolites,
influencing
brain
health.
Future
studies
employing
longitudinal
designs
advanced
omics
technologies
essential
developing
targeted
microbiome-based
therapies
for
managing
AD-related
disorders.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(14), С. 11296 - 11296
Опубликована: Июль 10, 2023
Thiamine
(vitamin
B1)
is
essential
for
the
brain.
This
attributed
to
coenzyme
role
of
thiamine
diphosphate
(ThDP)
in
glucose
and
energy
metabolism.
The
synthetic
prodrug,
thioester
benfotiamine
(BFT),
has
been
extensively
studied
beneficial
effects
both
rodent
models
neurodegeneration
human
clinical
studies.
BFT
no
known
adverse
improves
cognitive
outcomes
patients
with
mild
Alzheimer's
disease.
In
cell
culture
animal
models,
antioxidant
anti-inflammatory
properties
that
seem
be
mediated
by
a
mechanism
independent
function
ThDP.
Recent
vitro
studies
show
another
thioester,
O,S-dibenzoylthiamine
(DBT),
even
more
efficient
than
BFT,
especially
respect
its
potency,
effective
at
lower
concentrations.
thioesters
have
pleiotropic
linked
an
increase
circulating
concentrations
possibly
hitherto
unidentified
open
thiazole
ring
derivatives.
identification
active
neuroprotective
metabolites
clarification
their
action
extremely
promising
perspectives
field
neurodegenerative,
neurodevelopmental,
psychiatric
conditions.
present
review
aims
summarize
existing
data
on
give
comprehensive
account.
