Gut microbiota metabolites: potential therapeutic targets for Alzheimer’s disease? DOI Creative Commons
Shanshan Zhang,

Jing Lu,

Ziqi Jin

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 17, 2024

Background Alzheimer’s disease (AD) is a neurodegenerative characterized by progressive decline in cognitive function, which significantly increases pain and social burden. However, few therapeutic interventions are effective preventing or mitigating the progression of AD. An increasing number recent studies support hypothesis that gut microbiome its metabolites may be associated with upstream regulators AD pathology. Methods In this review, we comprehensively explore potential mechanisms currently available targeting for improvement Our discussion structured around modern research advancements AD, bidirectional communication between brain, multi-target regulatory effects microbial on strategies aimed at modulating microbiota to manage Results The plays crucial role pathogenesis through continuous via microbiota-gut-brain axis. Among these, such as lipids, amino acids, bile acids neurotransmitters, especially sphingolipids phospholipids, serve central components gut-brain axis, regulating AD-related pathogenic including β-amyloid metabolism, Tau protein phosphorylation, neuroinflammation. Additionally, probiotic administration, fecal transplantation, antibiotic use have also provided evidence supporting association At same time, propose an innovative strategy treating AD: healthy lifestyle combined targeted probiotics other interventions, aiming restore intestinal ecology balance. Conclusion Despite previous efforts, molecular microbes act yet fully described. microorganisms become essential target connecting axis improving symptoms it requires joint exploration multiple centers disciplines.

Language: Английский

Lingguizhugan decoction ameliorates cognitive impairment in AD-like mice by influencing the microbiome–gut–brain axis mediated by SCFAs DOI
Lisha Du, Jun Chen,

Jianyi Yan

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 133, P. 155942 - 155942

Published: Aug. 10, 2024

Language: Английский

Citations

5
The impact of physical exercise on neuroinflammation mechanism in Alzheimer’s disease DOI Creative Commons
Junhui Hu,

Baiqing Huang,

Kang Chen

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Aug. 21, 2024

Introduction Alzheimer’s disease (AD), a major cause of dementia globally, imposes significant societal and personal costs. This review explores the efficacy physical exercise as non-pharmacological intervention to mitigate impacts AD. Methods draws on recent studies that investigate effects neuroinflammation neuronal enhancement in individuals with Results Consistent alters neuroinflammatory pathways, enhances cognitive functions, bolsters brain health among AD patients. It favorably influences activation states microglia astrocytes, fortifies integrity blood-brain barrier, attenuates gut inflammation associated These changes are substantial improvements performance indicators. Discussion The findings underscore potential integrating into comprehensive management strategies. Emphasizing necessity for further research, this advocates refinement regimens maximize their enduring benefits decelerating progression

Language: Английский

Citations

5
Mechanistic Intimate Insights into the Role of Hydrogen Sulfide in Alzheimer’s Disease: A Recent Systematic Review DOI Open Access
Constantin Munteanu, Daniel Andrei Iordan,

Mihail Hoteteu

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15481 - 15481

Published: Oct. 23, 2023

In the rapidly evolving field of Alzheimer's Disease (AD) research, intricate role Hydrogen Sulfide (H

Language: Английский

Citations

11
Gut microbiota may affect Alzheimer's disease through synaptic function mediated by CAMs pathway: A study combining Mendelian randomization and bioinformatics DOI Creative Commons

Ji‐Yun Liu,

C.C. Tan, Li Luo

et al.

Journal of Alzheimer s Disease Reports, Journal Year: 2025, Volume and Issue: 9

Published: Jan. 1, 2025

The association between gut microbes and Alzheimer's disease (AD) has not been entirely elucidated. We aimed to demonstrate the AD further investigate pathogenesis of with a causal relationship AD. Mendelian randomization analyses were used determine significant Protein-protein interaction (PPI) network was identify hub genes. Functional enrichment analysis reveal theoretically In present study, total 32 identified that significantly associated Subsequently, DLGAP2, NRXN3, NEGR1, NTNAP2, MYH9, SCN3A as genes NTNAP2 enriched in cell adhesion molecules (CAMs) signaling, taxons corresponded these Bifidobacterium adolescentis, Actinomycetales, Intestinimonas massiliensis. massiliensis may promote progression through regulation CAMs signaling pathway-mediated synaptic function. Hence, in-depth study increase efficiency screening diagnosis

Language: Английский

Citations

0
Probiotics reverse gut dysbiosis and memory impairment associated with esomeprazole use in chronically stressed rats: A significant neuroprotective role for cholecystokinin DOI

Reem M Eladawy,

Lamiaa A. Ahmed, Maha B. Salem

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 150, P. 114227 - 114227

Published: Feb. 13, 2025

Language: Английский

Citations

0
High Altitude Microbiome: Insight into Yak Gut Microbiota and its Nutritional and Functional Involvement for Food Systems DOI
Muhammad Fakhar‐e‐Alam Kulyar, Quan Mo, Shah Nawaz

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104897 - 104897

Published: Feb. 1, 2025

Language: Английский

Citations

0
Oxidative Stress, Gut Microbiota, and Extracellular Vesicles: Interconnected Pathways and Therapeutic Potentials DOI Open Access
Bo Ma, Muttiah Barathan, Min Hwei Ng

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3148 - 3148

Published: March 28, 2025

Oxidative stress (OS) and gut microbiota are crucial factors influencing human health, each playing a significant role in the development progression of chronic diseases. This review provides comprehensive analysis complex interplay between these two factors, focusing on how an imbalance reactive oxygen species (ROS) antioxidants leads to OS, disrupting cellular homeostasis contributing range conditions, including metabolic disorders, cardiovascular diseases, neurological cancer. The microbiota, diverse community microorganisms residing gastrointestinal tract, is essential for regulating immune responses, pathways, overall health. Dysbiosis, composition, closely associated with inflammation, dysfunction, various highlights influences influenced by complicating pathophysiology many conditions. Furthermore, emerging evidence has identified extracellular vesicles (EVs) as critical facilitators crosstalk OS microbiota. EVs also play signaling host tissues, modulating processes. function holds promise targeted therapies aimed at restoring microbial balance mitigating OS. Personalized therapeutic approaches, probiotics, antioxidants, fecal transplantation-based strategies, can be used address OS-related diseases improve health outcomes. Nonetheless, further research needed study molecular mechanisms underlying interactions potential innovative interventions offer novel strategies managing enhancing

Language: Английский

Citations

0
The Role of Bacteria-Derived Hydrogen Sulfide in Multiple Axes of Disease DOI Open Access
Aleksandr Birg, Henry C. Lin

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3340 - 3340

Published: April 3, 2025

In this review article, we discuss and explore the role of bacteria-derived hydrogen sulfide. Hydrogen sulfide is a signaling molecule produced endogenously that plays an important in health disease. It also by gut microbiome. setting microbial disturbances leading to disruption intestinal homeostasis (dysbiosis), concentration available can vary pathologic sequelae. The brain-gut axis original studied paradigm microbiome host interaction. recent years, our understanding interaction has expanded greatly include specific pathways have branched into their own axes. These axes share principal concept microbiota changes, permeability, inflammatory response, some which are modulated (H2S). review, will multiple including gut-immune, gut-heart, gut-endocrine We evaluate H2S modulation barrier, mucosal healing inflammation tumor genesis. alpha-synuclein aggregation ischemic injury. Finally, metabolic syndrome as int pertains hypertension, atherosclerosis glucose-like peptide-1 activity. Majority studies focus on endogenous production; examine lesser-known source progression diseases it relates these

Language: Английский

Citations

0
Microbial diversity and fitness in the gut–brain axis: influences on developmental risk for Alzheimer’s disease DOI Creative Commons
Angelo Jamerlan, Seong Soo A. An, John Hulme

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 10, 2025

The gut-brain axis (GBA) denotes the dynamic and bidirectional communication system that connects gastrointestinal tract central nervous (CNS). This review explored this axis, focusing on role of microbial diversity fitness in maintaining health preventing neurodegeneration, particularly Alzheimer's disease (AD). Gut dysbiosis, characterized by imbalance populations beneficial harmful bacteria, has been associated with increased systemic inflammation, neuroinflammation, progression AD through pathogenic mechanisms involving amyloid deposition, tauopathy, blood-brain barrier (BBB) permeability. Emerging evidence highlighted therapeutic potential probiotics, dietary interventions, intermittent fasting restoring balance, reducing minimizing neurodegenerative risks. Probiotics synbiotics are promising helping improve cognitive function metabolic health, while patterns like Mediterranean diet were linked to decreased neuroinflammation enhanced communication. Despite significant advancement, further research is needed elucidate specific strains, metabolites, influencing brain health. Future studies employing longitudinal designs advanced omics technologies essential developing targeted microbiome-based therapies for managing AD-related disorders.

Language: Английский

Citations

0
Synthetic Thioesters of Thiamine: Promising Tools for Slowing Progression of Neurodegenerative Diseases DOI Open Access
Lucien Bettendorff

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(14), P. 11296 - 11296

Published: July 10, 2023

Thiamine (vitamin B1) is essential for the brain. This attributed to coenzyme role of thiamine diphosphate (ThDP) in glucose and energy metabolism. The synthetic prodrug, thioester benfotiamine (BFT), has been extensively studied beneficial effects both rodent models neurodegeneration human clinical studies. BFT no known adverse improves cognitive outcomes patients with mild Alzheimer's disease. In cell culture animal models, antioxidant anti-inflammatory properties that seem be mediated by a mechanism independent function ThDP. Recent vitro studies show another thioester, O,S-dibenzoylthiamine (DBT), even more efficient than BFT, especially respect its potency, effective at lower concentrations. thioesters have pleiotropic linked an increase circulating concentrations possibly hitherto unidentified open thiazole ring derivatives. identification active neuroprotective metabolites clarification their action extremely promising perspectives field neurodegenerative, neurodevelopmental, psychiatric conditions. present review aims summarize existing data on give comprehensive account.

Language: Английский

Citations

7