Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: unknown, P. 104761 - 104761
Published: Oct. 1, 2024
Language: Английский
Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 789 - 789
Published: July 3, 2024
Alginate is a natural polymer with good biocompatible properties and potential polymeric material for the sustainable development replacement of petroleum derivatives. However, non-spinnability pure alginate solutions has hindered expansion applications. With continuous electrospinning technology, synthetic polymers, such as PEO PVA, are used co-spinning agents to increase spinnability alginate. Moreover, coaxial, parallel Janus, tertiary other diverse novel electrospun fiber structures prepared by multi-fluid have found new breakthrough problem poor spinning polymers. Meanwhile, effectively achieve multiple release modes drugs. The powerful combination electrostatic widely in many biomedical fields, tissue engineering, regenerative bioscaffolds, drug delivery, research fever continues climb. This particularly true controlled delivery aspect review provides brief overview alginate, introduces advances spinning, highlights progress alginate-based nanofibers achieving various modes, pulsed release, sustained biphasic responsive targeted release.
Language: Английский
Citations
52
Progress in Materials Science, Journal Year: 2024, Volume and Issue: 147, P. 101350 - 101350
Published: Aug. 6, 2024
Wound healing is a complex biological process that, when impaired, can lead to the formation of scars. Electrospun nanofibrous wound dressings have emerged as promising option for promoting scar-free healing. This paper explores role physical, compositional, and chemical cues, each contributing remarkable potential these dressings. The physical properties dressings, such porosity mechanical characteristics, guide cellular behaviors promote vascularization, fostering conducive environment reduced scarring. Furthermore, integration natural polymers that mimic skin's extracellular matrix, known compositional adds another layer complexity As therapeutic agents demonstrated their combat chronic scenarios leading scar formation. However, achieving desired effect hinges on nature controlled release. Therefore, also delves into various loading techniques tailoring release profiles bioactive agents. Although electrospun are viable commercial product remains elusive. gap be attributed lack comprehensive in vivo studies, particularly animal models human
Language: Английский
Citations
43
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 348, P. 122856 - 122856
Published: Oct. 10, 2024
Language: Английский
Citations
25
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 135753 - 135753
Published: Oct. 17, 2024
Language: Английский
Citations
25
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9524 - 9524
Published: Sept. 1, 2024
Core–shell nanostructures are powerful platforms for the development of novel nanoscale drug delivery systems with sustained release profiles. Coaxial electrospinning is facile and convenient creating medicated core–shell elaborate designs which sustained-release behaviors molecules can be intentionally adjusted. With resveratrol (RES) as a model poorly water-soluble cellulose acetate (CA) PVP polymeric carriers, brand-new electrospun nanostructure was fabricated in this study. The guest RES host CA were designed to have reverse gradient distribution within nanostructures. Scanning electron microscope transmission evaluations verified that these nanofibers had linear morphologies, without beads or spindles, an obvious double-chamber structure. X-ray diffraction patterns Fourier transform infrared spectroscopic results indicated involved components highly compatible presented amorphous molecular state. In vitro dissolution tests new structures able prevent initial burst release, extend continuous-release time period, reduce negative tailing-off effect, thus ensuring better profile than traditional blended drug-loaded nanofibers. mechanism underlying influence structure RES/CA on proposed. Based proof-of-concept demonstration, series advanced functional nanomaterials similarly developed based distributions multi-chamber
Language: Английский
Citations
24
Progress in Materials Science, Journal Year: 2024, Volume and Issue: unknown, P. 101376 - 101376
Published: Sept. 1, 2024
Language: Английский
Citations
21
Polymers, Journal Year: 2024, Volume and Issue: 16(18), P. 2614 - 2614
Published: Sept. 15, 2024
Polymeric composites for manipulating the sustained release of an encapsulated active ingredient are highly sought after many practical applications; particularly, water-insoluble polymers and core–shell structures frequently explored to manipulate behaviors drug molecules over extended time period. In this study, electrospun nanostructures were utilized develop a brand-new strategy tailor spatial distributions both insoluble polymer (ethylcellulose, EC) soluble (polyvinylpyrrolidone, PVP) within nanofibers, thereby extended-release loaded ingredient, ferulic acid (FA). Scanning electron microscopy transmission assessments revealed that all prepared nanofibers had linear morphology without beads or spindles, those from coaxial processes obvious structure. X-ray diffraction attenuated total reflectance Fourier transform infrared spectroscopic tests confirmed FA fine compatibility with EC PVP, presented in amorphous state. vitro dissolution indicated radical (decreasing shell core) PVP (increasing able play their important role elaborately. On one hand, F3 advantages homogeneous composite F1 higher content solutions inhibit initial burst provide longer period release. other F2 core negative tailing-off The key element was water permeation rates, controlled by ratios polymers. new based on structure paves way developing wide variety polymeric heterogeneous realizing desired functional performances.
Language: Английский
Citations
20
Journal of Food Science, Journal Year: 2024, Volume and Issue: 89(11), P. 7803 - 7818
Published: Oct. 8, 2024
Abstract Bio‐based active food packaging materials have a high market demand. We use coaxial electrospinning technology to prepare core–shell structured nanofibers with sustained antibacterial and antioxidant properties. The fiber core layer was composed of gelatin tea polyphenols, whereas polyphenols provide properties; the sheath pullulan polysaccharides By using scanning electron microscope, it can be seen that diameter distribution prepared uniform surface is smooth; transmission clearly structure; Fourier Transform Infrared X‐ray diffraction analysis indicate an amorphous 2,2‐diphenyl‐1‐picrylhydrazyl free radical scavenging shows higher properties addition polyphenols; test showed had obvious inhibitory effect on growth Staphylococcus aureus Escherichia coli ; nanofiber film dissolution used as fast soluble packaging. Finally, core–sheath‐structured serve for instant food, possessing both rapid water solubility excellent activity, making water‐soluble interesting applications in field
Language: Английский
Citations
20
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 506, P. 160117 - 160117
Published: Jan. 1, 2025
Language: Английский
Citations
8
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 106, P. 106681 - 106681
Published: Feb. 7, 2025
Language: Английский
Citations
5