Proceedings of the National Academy of Sciences,
Год журнала:
2016,
Номер
114(3), С. 492 - 497
Опубликована: Дек. 29, 2016
Tumor
microvasculature
tends
to
be
malformed,
more
permeable,
and
tortuous
than
vessels
in
healthy
tissue,
effects
that
have
been
largely
attributed
up-regulated
VEGF
expression.
However,
tumor
tissue
stiffen
during
solid
progression,
stiffness
is
known
alter
cell
behaviors
including
proliferation,
migration,
cell-cell
adhesion,
which
are
all
requisite
for
angiogenesis.
Using
vitro,
vivo,
ex
ovo
models,
we
investigated
the
of
matrix
on
vessel
growth
integrity
Our
data
indicate
angiogenic
outgrowth,
invasion,
neovessel
branching
increase
with
cross-linking.
These
caused
by
increased
independent
density,
because
density
results
decreased
Notably,
up-regulates
metalloproteinase
(MMP)
activity,
inhibiting
MMPs
significantly
reduces
outgrowth
stiffer
cross-linked
gels.
To
investigate
functional
significance
altered
endothelial
behavior
response
stiffness,
measured
barrier
function
substrates
mimicking
tissue.
impaired
localization
vascular
cadherin
as
stiffness.
demonstrate
separately
from
can
integrity,
changes
exist
vasculature.
suggest
therapeutically
targeting
or
stiffening
may
help
restore
structure,
minimize
metastasis,
aid
drug
delivery.
Nature Communications,
Год журнала:
2020,
Номер
11(1)
Опубликована: Окт. 9, 2020
Abstract
Tissues
are
dynamically
shaped
by
bidirectional
communication
between
resident
cells
and
the
extracellular
matrix
(ECM)
through
cell-matrix
interactions
ECM
remodelling.
Tumours
leverage
remodelling
to
create
a
microenvironment
that
promotes
tumourigenesis
metastasis.
In
this
review,
we
focus
on
how
tumour
tumour-associated
stromal
deposit,
biochemically
biophysically
modify,
degrade
ECM.
These
tumour-driven
changes
support
growth,
increase
migration
of
cells,
remodel
in
distant
organs
allow
for
metastatic
progression.
A
better
understanding
underlying
mechanisms
tumourigenic
is
crucial
developing
therapeutic
treatments
patients.
Science,
Год журнала:
2016,
Номер
352(6283), С. 353 - 358
Опубликована: Март 25, 2016
Repairing
tears
in
the
nuclear
envelope
The
segregates
genomic
DNA
from
cytoplasm
and
regulates
protein
trafficking
between
cytosol
nucleus.
Maintaining
integrity
during
interphase
is
considered
crucial.
However,
Raab
et
al.
Denais
show
that
migrating
immune
cancer
cells
experience
frequent
transitory
ruptures
when
they
move
through
tight
spaces
(see
Perspective
by
Burke).
reseals
rapidly
interphase,
assisted
components
of
ESCRT
III
membrane-remodeling
machinery.
Science
,
this
issue
pp.
359
353
;
see
also
p.
295
Science,
Год журнала:
2016,
Номер
352(6283), С. 359 - 362
Опубликована: Март 25, 2016
Repairing
tears
in
the
nuclear
envelope
The
segregates
genomic
DNA
from
cytoplasm
and
regulates
protein
trafficking
between
cytosol
nucleus.
Maintaining
integrity
during
interphase
is
considered
crucial.
However,
Raab
et
al.
Denais
show
that
migrating
immune
cancer
cells
experience
frequent
transitory
ruptures
when
they
move
through
tight
spaces
(see
Perspective
by
Burke).
reseals
rapidly
interphase,
assisted
components
of
ESCRT
III
membrane-remodeling
machinery.
Science
,
this
issue
pp.
359
353
;
see
also
p.
295
Current Opinion in Cell Biology,
Год журнала:
2015,
Номер
36, С. 13 - 22
Опубликована: Июль 14, 2015
Metastasis
begins
with
the
invasion
of
tumor
cells
into
stroma
and
migration
toward
blood
stream.
Human
pathology
studies
suggest
that
invade
collectively
as
strands,
cords
clusters
stroma,
which
is
dramatically
reorganized
during
cancer
progression.
Cancer
in
intravital
mouse
models
vitro
display
many
‘modes’
migration,
from
single
isolated
round
or
elongated
phenotypes
to
loosely-/non-adherent
‘streams’
collective
cell
strands
sheets.
The
microenvironment,
particular
organization,
influences
mode
dynamics
invasion.
Future
will
clarify
how
combination
stromal
network
structure,
signaling
extracellular
cues
influence
metastasis.
Chemical Reviews,
Год журнала:
2017,
Номер
117(20), С. 12764 - 12850
Опубликована: Окт. 9, 2017
The
cell
microenvironment
has
emerged
as
a
key
determinant
of
behavior
and
function
in
development,
physiology,
pathophysiology.
extracellular
matrix
(ECM)
within
the
serves
not
only
structural
foundation
for
cells
but
also
source
three-dimensional
(3D)
biochemical
biophysical
cues
that
trigger
regulate
behaviors.
Increasing
evidence
suggests
3D
character
is
required
development
many
critical
responses
observed
vivo,
fueling
surge
functional
biomimetic
materials
engineering
microenvironment.
Progress
design
such
improved
control
behaviors
advanced
fields
tissue
regeneration,
vitro
models,
large-scale
differentiation,
immunotherapy,
gene
therapy.
However,
field
still
its
infancy,
discoveries
about
nature
cell–microenvironment
interactions
continue
to
overturn
much
early
progress
field.
Key
challenges
be
dissecting
roles
chemistry,
structure,
mechanics,
electrophysiology
microenvironment,
understanding
harnessing
periodicity
drift
these
factors.
This
review
encapsulates
where
recent
advances
appear
leave
ever-shifting
state
art,
it
highlights
areas
which
substantial
potential
uncertainty
remain.
