Cancer Discovery,
Journal Year:
2018,
Volume and Issue:
9(1), P. 64 - 81
Published: Oct. 2, 2018
Abstract
Physical
changes
in
skin
are
among
the
most
visible
signs
of
aging.
We
found
that
young
dermal
fibroblasts
secrete
high
levels
extracellular
matrix
(ECM)
constituents,
including
proteoglycans,
glycoproteins,
and
cartilage-linking
proteins.
The
abundantly
secreted
was
HAPLN1,
a
hyaluronic
proteoglycan
link
protein.
HAPLN1
lost
aged
fibroblasts,
resulting
more
aligned
ECM
promoted
metastasis
melanoma
cells.
Reconstituting
inhibited
an
microenvironment,
3-D
reconstruction
models,
vivo.
Intriguingly,
fibroblast-derived
matrices
had
opposite
effect
on
migration
T
cells,
inhibiting
their
motility.
treatment
restored
motility
mononuclear
immune
while
impeding
polymorphonuclear
which
turn
affected
regulatory
T-cell
recruitment.
These
data
suggest
although
age-related
physical
can
promote
tumor
cell
motility,
they
may
adversely
affect
some
overall
change
microenvironment.
Understanding
aging
provide
avenues
for
effective
therapy
older
patients
with
melanoma.
Significance:
shed
light
mechanochemical
interactions
occur
between
skin,
tumor,
populations,
infiltration,
implications
efficacy
current
therapies
See
related
commentary
by
Marie
Merlino,
p.
19.
This
article
is
highlighted
In
Issue
feature,
1
Nature Communications,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: Oct. 9, 2020
Abstract
Tissues
are
dynamically
shaped
by
bidirectional
communication
between
resident
cells
and
the
extracellular
matrix
(ECM)
through
cell-matrix
interactions
ECM
remodelling.
Tumours
leverage
remodelling
to
create
a
microenvironment
that
promotes
tumourigenesis
metastasis.
In
this
review,
we
focus
on
how
tumour
tumour-associated
stromal
deposit,
biochemically
biophysically
modify,
degrade
ECM.
These
tumour-driven
changes
support
growth,
increase
migration
of
cells,
remodel
in
distant
organs
allow
for
metastatic
progression.
A
better
understanding
underlying
mechanisms
tumourigenic
is
crucial
developing
therapeutic
treatments
patients.
Science,
Journal Year:
2016,
Volume and Issue:
352(6283), P. 353 - 358
Published: March 25, 2016
Repairing
tears
in
the
nuclear
envelope
The
segregates
genomic
DNA
from
cytoplasm
and
regulates
protein
trafficking
between
cytosol
nucleus.
Maintaining
integrity
during
interphase
is
considered
crucial.
However,
Raab
et
al.
Denais
show
that
migrating
immune
cancer
cells
experience
frequent
transitory
ruptures
when
they
move
through
tight
spaces
(see
Perspective
by
Burke).
reseals
rapidly
interphase,
assisted
components
of
ESCRT
III
membrane-remodeling
machinery.
Science
,
this
issue
pp.
359
353
;
see
also
p.
295
Science,
Journal Year:
2016,
Volume and Issue:
352(6283), P. 359 - 362
Published: March 25, 2016
Repairing
tears
in
the
nuclear
envelope
The
segregates
genomic
DNA
from
cytoplasm
and
regulates
protein
trafficking
between
cytosol
nucleus.
Maintaining
integrity
during
interphase
is
considered
crucial.
However,
Raab
et
al.
Denais
show
that
migrating
immune
cancer
cells
experience
frequent
transitory
ruptures
when
they
move
through
tight
spaces
(see
Perspective
by
Burke).
reseals
rapidly
interphase,
assisted
components
of
ESCRT
III
membrane-remodeling
machinery.
Science
,
this
issue
pp.
359
353
;
see
also
p.
295
Current Opinion in Cell Biology,
Journal Year:
2015,
Volume and Issue:
36, P. 13 - 22
Published: July 14, 2015
Metastasis
begins
with
the
invasion
of
tumor
cells
into
stroma
and
migration
toward
blood
stream.
Human
pathology
studies
suggest
that
invade
collectively
as
strands,
cords
clusters
stroma,
which
is
dramatically
reorganized
during
cancer
progression.
Cancer
in
intravital
mouse
models
vitro
display
many
‘modes’
migration,
from
single
isolated
round
or
elongated
phenotypes
to
loosely-/non-adherent
‘streams’
collective
cell
strands
sheets.
The
microenvironment,
particular
organization,
influences
mode
dynamics
invasion.
Future
will
clarify
how
combination
stromal
network
structure,
signaling
extracellular
cues
influence
metastasis.
Chemical Reviews,
Journal Year:
2017,
Volume and Issue:
117(20), P. 12764 - 12850
Published: Oct. 9, 2017
The
cell
microenvironment
has
emerged
as
a
key
determinant
of
behavior
and
function
in
development,
physiology,
pathophysiology.
extracellular
matrix
(ECM)
within
the
serves
not
only
structural
foundation
for
cells
but
also
source
three-dimensional
(3D)
biochemical
biophysical
cues
that
trigger
regulate
behaviors.
Increasing
evidence
suggests
3D
character
is
required
development
many
critical
responses
observed
vivo,
fueling
surge
functional
biomimetic
materials
engineering
microenvironment.
Progress
design
such
improved
control
behaviors
advanced
fields
tissue
regeneration,
vitro
models,
large-scale
differentiation,
immunotherapy,
gene
therapy.
However,
field
still
its
infancy,
discoveries
about
nature
cell–microenvironment
interactions
continue
to
overturn
much
early
progress
field.
Key
challenges
be
dissecting
roles
chemistry,
structure,
mechanics,
electrophysiology
microenvironment,
understanding
harnessing
periodicity
drift
these
factors.
This
review
encapsulates
where
recent
advances
appear
leave
ever-shifting
state
art,
it
highlights
areas
which
substantial
potential
uncertainty
remain.
