Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Май 18, 2022
Autophagy
and
RNA
alternative
splicing
are
two
evolutionarily
conserved
processes
involved
in
overlapping
physiological
pathological
processes.
However,
the
extent
of
functional
connection
is
not
well
defined.
Here,
we
consider
role
for
generation
autophagy-related
gene
isoforms
regulation
autophagy
recent
work.
The
impact
changes
to
machinery
production
spliced
on
reviewed
with
particular
focus
disease
relevance.
use
drugs
targeting
both
as
selective
single
protein
isoforms,
considered
therapeutic
strategies.
Molecular Metabolism,
Год журнала:
2023,
Номер
74, С. 101755 - 101755
Опубликована: Июнь 16, 2023
Recently,
the
hallmarks
of
aging
were
updated
to
include
dysbiosis,
disabled
macroautophagy,
and
chronic
inflammation.
In
particular,
low-grade
inflammation
during
aging,
without
overt
infection,
is
defined
as
"inflammaging,"
which
associated
with
increased
morbidity
mortality
in
population.
Emerging
evidence
suggests
a
bidirectional
cyclical
relationship
between
development
age-related
conditions,
such
cardiovascular
diseases,
neurodegeneration,
cancer,
frailty.
How
crosstalk
other
underlies
biological
mechanisms
disease
thus
particular
interest
current
geroscience
research.
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Июль 8, 2022
Abstract
Liquid–liquid
phase
separation
(LLPS)
is
a
novel
principle
for
explaining
the
precise
spatial
and
temporal
regulation
in
living
cells.
LLPS
compartmentalizes
proteins
nucleic
acids
into
micron-scale,
liquid-like,
membraneless
bodies
with
specific
functions,
which
were
recently
termed
biomolecular
condensates.
Biomolecular
condensates
are
executors
underlying
intracellular
spatiotemporal
coordination
of
various
biological
activities,
including
chromatin
organization,
genomic
stability,
DNA
damage
response
repair,
transcription,
signal
transduction.
Dysregulation
these
cellular
processes
key
event
initiation
and/or
evolution
cancer,
emerging
evidence
has
linked
formation
to
malignant
transformations
tumor
biology.
In
this
review,
we
comprehensively
summarize
detailed
mechanisms
condensate
biophysical
function
review
recent
major
advances
toward
elucidating
multiple
involved
cancer
cell
pathology
driven
by
aberrant
LLPS.
addition,
discuss
therapeutic
perspectives
research
most
developed
drug
candidates
targeting
modulation
that
can
be
used
combat
tumorigenesis.
Autophagy,
Год журнала:
2024,
Номер
20(6), С. 1213 - 1246
Опубликована: Март 6, 2024
Macroautophagy/autophagy
is
a
complex
degradation
process
with
dual
role
in
cell
death
that
influenced
by
the
types
are
involved
and
stressors
they
exposed
to.
Ferroptosis
an
iron-dependent
oxidative
form
of
characterized
unrestricted
lipid
peroxidation
context
heterogeneous
plastic
mechanisms.
Recent
studies
have
shed
light
on
involvement
specific
autophagy
(e.g.
ferritinophagy,
lipophagy,
clockophagy)
initiating
or
executing
ferroptotic
through
selective
anti-injury
proteins
organelles.
Conversely,
other
forms
reticulophagy
lysophagy)
enhance
cellular
defense
against
damage.
Dysregulated
autophagy-dependent
ferroptosis
has
implications
for
diverse
range
pathological
conditions.
This
review
aims
to
present
updated
definition
ferroptosis,
discuss
influential
substrates
receptors,
outline
experimental
methods,
propose
guidelines
interpreting
results.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(7), С. 3253 - 3272
Опубликована: Янв. 1, 2024
This
review
delineates
emerging
technologies
for
targeted
protein
degradation
that
directly
involve
lysosomes
or
proteasomes.
It
explores
their
unique
features,
advantages,
and
limitations,
offering
perspectives
on
future
therapeutic
applications.
Soft Matter,
Год журнала:
2025,
Номер
21(10), С. 1781 - 1812
Опубликована: Янв. 1, 2025
Peptide-mediated
liquid–liquid
phase
separation
(LLPS)
underpins
the
formation
of
dynamic
biomolecular
condensates,
regulated
by
diverse
molecular
interactions,
and
highlights
potential
applications
in
drug
delivery
synthetic
biology.
