Cancers,
Год журнала:
2023,
Номер
15(3), С. 920 - 920
Опубликована: Фев. 1, 2023
B
cells
are
multifaceted
immune
responding
robustly
during
surveillance
against
tumor
antigens
by
presentation
to
T
and
switched
immunoglobulin
production.
However,
unstudied
in
prostate
cancer
(PCa).
We
used
flow
cytometry
analyze
B-cell
subpopulations
peripheral
blood
lymph
nodes
from
intermediate-high
risk
PCa
patients.
were
related
clinicopathological
factors.
B-cell-receptor
single-cell
sequencing
VDJ
analysis
identified
clonal
expansion
nodes.
Pathological
staging
was
pT2
16%,
pT3a
48%,
pT3b
36%.
Lymph
node
metastases
occurred
5/25
patients
(20%).
Compared
healthy
donors,
the
CD19+
compartment
significantly
decreased
dominated
naïve
cells.
The
nodal
had
increased
fractions
of
memory
Plasmablasts
observed
tumor-draining
sentinel
(SNs).
revealed
Thus,
activated
SNs
fraction
plasmablasts
together
with
presence
clonally
expanded
indicate
tumor-specific
T-cell-dependent
responses
cells,
supporting
an
important
role
for
protection
tumors.
Cancers,
Год журнала:
2022,
Номер
14(7), С. 1681 - 1681
Опубликована: Март 25, 2022
Our
body
is
constantly
exposed
to
pathogens
or
external
threats,
but
with
the
immune
response
that
our
can
develop,
we
fight
off
and
defeat
possible
attacks
infections.
Nevertheless,
sometimes
this
threat
comes
from
an
internal
factor.
Situations
such
as
existence
of
a
tumour
also
cause
system
(IS)
be
put
on
alert.
Indeed,
link
between
immunology
cancer
evident
these
days,
IS
being
used
one
important
targets
for
treating
cancer.
able
eliminate
those
abnormal
damaged
cells
found
in
body,
preventing
uncontrolled
proliferation
lead
However,
several
cases,
escape
IS.
It
has
been
observed
cells,
extracellular
matrix,
blood
vessels,
fat
various
molecules
could
support
growth
development.
Thus,
developing
receives
structural
support,
irrigation
energy,
among
other
resources,
making
its
survival
progression
possible.
All
components
accompany
help
survive
grow
are
called
microenvironment
(TME).
Given
importance
presence
development
process,
review
will
focus
TME:
cells.
Immune
anti-tumour
protecting
us
against
cells;
nevertheless,
they
behave
pro-tumoural
thus
promoting
survival.
In
review,
pro-tumour
immunity
discussed.
addition,
TME
influence
dual
effect
analysed.
Cell Reports,
Год журнала:
2022,
Номер
40(9), С. 111298 - 111298
Опубликована: Авг. 1, 2022
Circulating
tumor
cells
(CTCs)
are
the
seeds
of
distant
metastasis,
and
number
CTCs
detected
in
blood
cancer
patients
is
associated
with
a
worse
prognosis.
face
critical
challenges
for
their
survival
circulation,
such
as
anoikis,
shearing
forces,
immune
surveillance.
Thus,
understanding
mechanisms
interactions
within
microenvironment
crucial
better
metastatic
progression
development
novel
treatment
strategies.
interact
different
hematopoietic
cells,
platelets,
red
neutrophils,
macrophages,
natural
killer
(NK)
lymphocytes,
endothelial
cancer-associated
fibroblasts,
which
can
affect
CTC
blood.
This
interaction
may
take
place
either
via
direct
cell-cell
contact
or
through
secreted
molecules.
Here,
we
review
discuss
potential
clinical
relevance
these
biomarkers
targets
anti-metastatic
therapies.
Journal of Clinical Medicine,
Год журнала:
2023,
Номер
12(13), С. 4301 - 4301
Опубликована: Июнь 27, 2023
Checkpoint
proteins
are
an
integral
part
of
the
immune
system
and
used
by
tumor
cells
to
evade
response,
which
helps
them
grow
uncontrollably.
By
blocking
these
proteins,
checkpoint
inhibitors
can
restore
capability
attack
cancer
stop
their
growth.
These
findings
backed
adequate
clinical
trial
data
presently,
several
FDA-approved
exist
in
market
for
treating
various
types
cancers,
including
melanoma,
hepatocellular,
endometrial,
lung,
kidney
others.
Their
mode
action
is
inhibition
targeting
CTLA-4,
PD-1,
PD-L1,
etc.
They
be
alone
as
well
amalgamation
with
other
treatments,
like
surgery,
radiation
or
chemotherapy.
Since
drugs
target
only
specific
side
effects
reduced
comparison
traditional
chemotherapy
drugs,
but
may
still
cause
a
few
affects
fatigue,
skin
rashes,
fever.
In
rare
cases,
known
have
caused
more
serious
effects,
such
cardiotoxicity,
inflammation
intestines
lungs.
Herein,
we
provide
overview
role
biomarkers,
immune-related
adverse
outcomes
studies
treatment
present
some
future
perspectives.
Cell,
Год журнала:
2024,
Номер
187(17), С. 4790 - 4811.e22
Опубликована: Июль 23, 2024
Characterizing
the
compositional
and
phenotypic
characteristics
of
tumor-infiltrating
B
cells
(TIBs)
is
important
for
advancing
our
understanding
their
role
in
cancer
development.
Here,
we
establish
a
comprehensive
resource
human
by
integrating
single-cell
RNA
sequencing
data
from
649
patients
across
19
major
types.
We
demonstrate
substantial
heterogeneity
total
abundance
subtype
composition
observe
immunoglobulin
G
(IgG)-skewness
antibody-secreting
cell
isotypes.
Moreover,
identify
stress-response
memory
tumor-associated
atypical
(TAABs),
two
tumor-enriched
subpopulations
with
prognostic
potential,
shared
pan-cancer
manner.
In
particular,
TAABs,
characterized
high
clonal
expansion
level
proliferative
capacity
as
well
close
interactions
activated
CD4
T
tumors,
are
predictive
immunotherapy
response.
Our
integrative
depicts
distinct
clinically
relevant
TIB
subsets,
laying
foundation
further
exploration
functional
commonality
diversity
cancer.
Frontiers in Immunology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 7, 2025
Gastric
cancer
is
a
common
malignant
tumor
of
the
digestive
tract,
and
its
treatment
remains
significant
challenge.
In
recent
years,
role
various
immune
cells
in
microenvironment
progression
has
gained
increasing
attention.
Immunotherapy,
primarily
based
on
checkpoint
inhibitors,
notably
improved
prognosis
patients
with
gastric
cancer;
however,
challenges
regarding
therapeutic
efficacy
persist.
Histological
features
within
microenvironment,
such
as
tertiary
lymphoid
structures
(TLSs),
tumor-infiltrating
lymphocytes,
proportion
intratumoral
stroma,
are
emerging
potentially
effective
prognostic
factors.
cancer,
TLSs
may
serve
local
hubs,
enhancing
ability
to
interact
recognize
antigens,
which
closely
linked
effectiveness
immunotherapy
survival
rates
patients.
However,
specific
cell
type
driving
TLS
formation
tumors
not
yet
been
elucidated.
Mature
B-cell
regions
containing
germinal
centers.
During
center
formation,
B
undergo
transformations
become
mature
function,
exerting
anti-tumor
effects.
Therefore,
targeting
could
provide
new
avenues
for
immunotherapy.
This
review,
combined
current
research
elaborates
relationship
between
aiming
guidance
precise
