Contribution of Nucleotide-Binding Oligomerization Domain-like (NOD) Receptors to the Immune and Metabolic Health DOI Creative Commons

César Jeri Apaza,

Marisol Días, Aurora García-Tejedor

и другие.

Biomedicines, Год журнала: 2024, Номер 12(2), С. 341 - 341

Опубликована: Фев. 1, 2024

Nucleotide-binding oligomerization domain-like (NOD) receptors rely on the interface between immunity and metabolism. Dietary factors constitute critical players in activation of innate modulation gut microbiota. The latter have been involved worsening or improving control promotion diseases such as obesity, type 2 diabetes, metabolic syndrome, known non-communicable (NCDs), risk developing cancer. Intracellular NODs play key coordinated actions with immune ‘Toll-like’ leading to a diverse array gene expressions that initiate inflammatory responses. There has an improvement understanding molecular genetic implications these in, among others, aspects resting energy expenditure, insulin resistance, cell proliferation. Genetic polymorphisms are determinants severity NCDs cancer, it is conceivable dietary may significant differential consequences depending them. Host difficult influence, while environmental predominant approachable preventive and/or therapeutic intention T2D, However, beyond recognition by peptidoglycan its prototypical agonist, underlying response(s) remain ill-defined. Metabolic (re)programming hallmark cancer which nutritional strategies might role preventing unprecedented expansion diseases. A better participation effects immunonutritional ingredients can boost integrative knowledge fostering interdisciplinary science precision personalized medicine against This review summarizes current evidence concerning relationship(s) health.

Язык: Английский

Emerging mechanisms of obesity-associated immune dysfunction DOI
Saame Raza Shaikh, Melinda A. Beck,

Yazan Alwarawrah

и другие.

Nature Reviews Endocrinology, Год журнала: 2023, Номер 20(3), С. 136 - 148

Опубликована: Дек. 21, 2023

Язык: Английский

Процитировано

61
Western diets and chronic diseases DOI
Timon E. Adolph, Herbert Tilg

Nature Medicine, Год журнала: 2024, Номер 30(8), С. 2133 - 2147

Опубликована: Июль 31, 2024

Язык: Английский

Процитировано

32
Unveiling the dynamics of gut microbial interactions: a review of dietary impact and precision nutrition in gastrointestinal health DOI Creative Commons
Zifang Shang,

Liu Pai,

Sandip Patil

и другие.

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Май 30, 2024

The human microbiome, a dynamic ecosystem within the gastrointestinal tract, plays pivotal role in shaping overall health. This review delves into six interconnected sections, unraveling intricate relationship between diet, gut microbiota, and their profound impact on dance of nutrients orchestrates complex symphony, influencing digestive processes susceptibility to disorders. Emphasizing bidirectional communication brain, Brain-Gut Axis section highlights crucial dietary choices physical, mental, emotional well-being. Autoimmune diseases, particularly those manifesting reveal delicate balance disrupted by microbiome imbalances. Strategies for reconciling microbes through diets, precision nutrition, clinical indications showcase promising avenues managing distress revolutionizing healthcare. From Low-FODMAP diet neuro-gut interventions, these strategies provide holistic understanding gut’s world. Precision as groundbreaking discipline, holds transformative potential tailoring recommendations individual microbiota compositions, reshaping landscape Recent advancements indications, including exact probiotics, fecal transplantation, signify new era where actively participates therapeutic strategies. As takes center stage healthcare, paradigm shift toward personalized effective treatments disorders emerges, reflecting symbiotic body its microbial companions.

Язык: Английский

Процитировано

10
Perspective: Challenges for Personalized Nutrition in the Current U.S. Regulatory Framework and Future Opportunities DOI Creative Commons
Sharon M. Donovan, Mariëtte Abrahams,

Joshua C. Anthony

и другие.

Advances in Nutrition, Год журнала: 2025, Номер unknown, С. 100382 - 100382

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2
Could a Mediterranean Diet Modulate Alzheimer’s Disease Progression? The Role of Gut Microbiota and Metabolite Signatures in Neurodegeneration DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Foods, Год журнала: 2025, Номер 14(9), С. 1559 - 1559

Опубликована: Апрель 29, 2025

Neurodegenerative disorders such as Alzheimer's disease (AD), the most common form of dementia, represent a growing global health crisis, yet current treatment strategies remain primarily palliative. Recent studies have shown that neurodegeneration through complex interactions within gut-brain axis largely depends on gut microbiota and its metabolites. This review explores intricate molecular mechanisms linking dysbiosis to cognitive decline, emphasizing impact microbial metabolites, including short-chain fatty acids (SCFAs), bile acids, tryptophan neuroinflammation, blood-brain barrier (BBB) integrity, amyloid-β tau pathology. The paper highlights major microbiome signatures associated with disease, detailing their metabolic pathways inflammatory crosstalk. Dietary interventions promise in modulating composition, potentially mitigating neurodegenerative processes. critically examines influence dietary patterns, Mediterranean Western diets, microbiota-mediated neuroprotection. Bioactive compounds like prebiotics, omega-3 polyphenols exhibit neuroprotective effects by reducing neuroinflammation. Furthermore, it discusses emerging microbiome-based therapeutic strategies, probiotics, postbiotics, fecal transplantation (FMT), potential for slowing progression. Despite these advances, several knowledge gaps remain, interindividual variability responses need large-scale, longitudinal studies. study proposes an integrative, precision medicine approach, incorporating science into paradigms. Ultimately, cognizance at mechanistic level could unlock novel avenues, offering non-invasive, diet-based strategy managing improving health.

Язык: Английский

Процитировано

2
Geriatric Nutritional Risk Index (GNRI) and Survival in Pancreatic Cancer: A Retrospective Study DOI Open Access
Christina Grinstead, Saunjoo L. Yoon

Nutrients, Год журнала: 2025, Номер 17(3), С. 509 - 509

Опубликована: Янв. 30, 2025

Introduction: Malnutrition is a major contributor to poor treatment and survival outcomes in pancreatic cancer, yet nutritional assessment not standardized or consistently implemented the care of oncology patients. The Geriatric Nutritional Risk Index (GNRI), calculated from serum albumin body weight, may be useful as practical tool for identifying patients at risk status. Purpose: To provide preliminary analysis using limited selection variables examine association GNRI diagnosis change over time with overall cancer. Methods: This retrospective study included 314 aged ≥18 years was ≥30 days later. Patients were categorized by (no >98, any ≤98) change/increase, mild decrease, severe decrease). Additional demographics stage. Comparative t-tests, chi-square tests, ANOVA. Survival analyzed Kaplan–Meier curves, log-rank Cox proportional hazards modeling. Results: Median significantly decreased any-nutritional-risk group compared no-nutritional-risk (442 vs. 1105 days), those experiencing decreases scores no increases (372.5 712 1791 respectively. stratified shows that both (HR 2.19, 95%, CI 1.46–3.30) 4.04, 2.64–6.18) independently associated versus increase after controlling Log-rank tests also show had lower than (p = 0.00052). Conclusions: Lower showing greater decreasing predictors Our findings indicate valid effective early identification high who require interventions improve However, more research needed larger samples variety confirm presence strength this relationship, effect patient factors known nutrition, explore potential influential confounders.

Язык: Английский

Процитировано

1
Personalized nutrition: perspectives on challenges, opportunities, and guiding principles for data use and fusion DOI Creative Commons
Sharon M. Donovan, Mariëtte Abrahams,

Joshua C. Anthony

и другие.

Critical Reviews in Food Science and Nutrition, Год журнала: 2025, Номер unknown, С. 1 - 18

Опубликована: Фев. 5, 2025

Personalized nutrition (PN) delivers tailored dietary guidance by integrating health, lifestyle, and behavioral data to improve individual health outcomes. Recent technological advances have enhanced access diverse sources, yet challenges remain in collecting, integrating, analyzing complex datasets. To address these, the Nutrition Initiative at Illinois organized a workshop titled "Personalized Data: Challenges & Opportunities," which gathered experts explore three essential domains PN: 1) biological, 2) social, behavioral, environmental, 3) consumer purchasing data. Discussions underscored importance of cross-disciplinary collaboration standardize collection, enable secure sharing, develop fusion techniques that respect privacy build trust. Participants emphasized need for representative datasets include underserved populations, ensuring PN services are accessible equitable. Key principles responsible integration were proposed, alongside strategies overcome barriers effective use. By addressing these challenges, can enhance outcomes through precise, personalized recommendations population needs.

Язык: Английский

Процитировано

1
Precision Nutrition: The Hype Is Exceeding the Science and Evidentiary Standards Needed to Inform Public Health Recommendations for Prevention of Chronic Disease DOI Creative Commons
Regan L Bailey, Patrick J. Stover

Annual Review of Nutrition, Год журнала: 2023, Номер 43(1), С. 385 - 407

Опубликована: Авг. 21, 2023

As dietary guidance for populations shifts from preventing deficiency disorders to chronic disease risk reduction, the biology supporting such becomes more complex due multifactorial profile of and inherent population heterogeneity in diet–disease relationship. Diet is a primary driver risk, population-based should account individual responses. Cascading effects on evidentiary standards are not straightforward. Precision remains consideration prevent through identification subgroups with unique nutritional needs. Reducing diet requires greater precision ( a) establishing essential nutrient needs throughout life cycle both health disease; b) considering nutrients other food substances metabolic, immunological, inflammatory, physiological responses healthy aging; c) eating behaviors. Herein we provide template guiding recommendations reducing diseases heterogenous populations.

Язык: Английский

Процитировано

20
Perspective: A Comprehensive Evaluation of Data Quality in Nutrient Databases DOI Creative Commons
Zhaoping Li, Shavawn M. Forester, Emily M. Jennings-Dobbs

и другие.

Advances in Nutrition, Год журнала: 2023, Номер 14(3), С. 379 - 391

Опубликована: Фев. 25, 2023

Nutrient databases are a critical component of nutrition science and the basis exciting new research in precision (PN). To identify most components needed for improvement nutrient databases, food composition data were analyzed quality, with completeness being important measure, FAIRness, how well conformed criteria findable, accessible, interoperable, reusable (FAIR). Databases judged complete if they provided all 15 fact panel (NFP) measures 40 National Academies Sciences, Engineering, Medicine (NASEM) essential each listed. Using gold standard USDA reference (SR) Legacy database as surrogate, it was found that SR not either NFP or NASEM measures. In addition, phytonutrient 4 Special Interest incomplete. evaluate set 175 sources collected from worldwide. Many opportunities identified improving including creating persistent URLs, prioritizing usable storage formats, providing Globally Unique Identifiers foods nutrients, implementing citation standards. This review demonstrates despite contributions others, their current forms do yet provide truly comprehensive data. We propose to enhance quality usage scientists those fashioning various PN tools, field must step out its historical comfort zone improve foundational used by incorporating principles, central FAIRness.

Язык: Английский

Процитировано

12
Best Time of Day for Strength and Endurance Training to Improve Health and Performance? A Systematic Review with Meta-analysis DOI Creative Commons
Fabienne Bruggisser, Raphael Knaier, Ralf Roth

и другие.

Sports Medicine - Open, Год журнала: 2023, Номер 9(1)

Опубликована: Май 19, 2023

Current recommendations for physical exercise include information about the frequency, intensity, type, and duration of exercise. However, to date, there are no on what time day one should The aim was perform a systematic review with meta-analysis investigate if training in intervention studies influences degree improvements performance or health-related outcomes. databases EMBASE, PubMed, Cochrane Library, SPORTDiscus were searched from inception January 2023. Eligibility criteria that conducted structured endurance and/or strength minimum two sessions per week at least 2 weeks compared between different times using randomized crossover parallel group design. From 14,125 screened articles, 26 articles included which seven also meta-analyses. Both qualitative synthesis quantitative (i.e., meta-analysis) provide little evidence against hypothesis specific leads more performance-related outcomes other times. There some is benefit when testing occur same day, mainly Overall, risk bias most high. current state research provides neither nor being beneficial, but larger effects congruency This improve design execution future this topic. PROSPERO (CRD42021246468).

Язык: Английский

Процитировано

12