Annual Review of Nutrition,
Год журнала:
2020,
Номер
40(1), С. 135 - 159
Опубликована: Июль 7, 2020
Natural
polyamines
(spermidine
and
spermine)
are
small,
positively
charged
molecules
that
ubiquitously
found
within
organisms
cells.
They
exert
numerous
(intra)cellular
functions
have
been
implicated
to
protect
against
several
age-related
diseases.
Although
polyamine
levels
decline
in
a
complex
age-dependent,
tissue-,
cell
type-specific
manner,
they
maintained
healthy
nonagenarians
centenarians.
Increased
levels,
including
through
enhanced
dietary
intake,
consistently
linked
improved
health
reduced
overall
mortality.
In
preclinical
models,
supplementation
with
spermidine
prolongs
life
span
span.
this
review,
we
highlight
salient
aspects
of
nutritional
intake
summarize
the
current
knowledge
organismal
cellular
uptake
distribution
(and
gastrointestinal)
their
impact
on
human
health.
We
further
clinical
epidemiological
studies
polyamines.
Gut Microbes,
Год журнала:
2020,
Номер
12(1), С. 1832857 - 1832857
Опубликована: Ноя. 5, 2020
Obesity
is
associated
with
impaired
intestinal
barrier
function
and
dysbiosis
of
the
gut
microbiota.
Spermidine,
a
polyamine
that
acts
as
an
autophagy
inducer,
has
important
benefits
in
patients
aging-associated
diseases
metabolic
dysfunction.
However,
mechanism
spermidine
on
obesity
remains
unclear.
Here,
we
show
intake
negatively
correlated
both
humans
mice.
Spermidine
supplementation
causes
significant
loss
weight
improves
insulin
resistance
diet-induced
obese
(DIO)
These
effects
are
alleviation
endotoxemia
enhancement
function,
which
might
be
mediated
through
pathway
TLR4-mediated
microbial
signaling
transduction.
Moreover,
alteration
microbiota
composition
function.
Microbiota
depletion
compromises
while
transplantation
spermidine-altered
confers
protection
against
obesity.
changes
partly
driven
by
SCFA-producing
bacterium,
Lachnospiraceae
NK4A136
group,
was
decreased
subjects
subsequently
increased
spermidine.
Notably,
change
group
significantly
enhanced
induced
Our
results
indicate
may
serve
viable
therapy
for
Marine Drugs,
Год журнала:
2018,
Номер
17(1), С. 1 - 1
Опубликована: Дек. 20, 2018
Microalgae
of
different
evolutionary
origins
are
typically
found
in
rivers,
lakes,
and
oceans,
providing
more
than
45%
global
primary
production.
They
provide
not
only
a
food
source
for
animals,
but
also
affect
microbial
ecosystems
through
symbioses
with
microorganisms
or
secretion
some
metabolites.
Derived
from
amino
acids,
polyamines
present
almost
all
types
organisms,
where
they
play
important
roles
maintaining
physiological
functions
against
stress.
can
produce
variety
distinct
polyamines,
the
polyamine
content
is
to
meet
needs
microalgae
may
other
species
environment.
In
addition,
produced
by
have
medical
nanotechnological
applications.
Previous
studies
on
several
indicated
that
putative
metabolic
pathways
be
as
complicated
genomes
these
which
contain
genes
originating
plants,
even
bacteria.
There
novel
synthetic
routes
microalgae.
Understanding
nature
will
improve
our
knowledge
microalgal
physiology
ecological
function,
valuable
information
biotechnological
Frontiers in Nutrition,
Год журнала:
2019,
Номер
6
Опубликована: Июль 11, 2019
The
polyamines
spermine,
spermidine,
and
putrescine
are
involved
in
various
biological
processes,
notably
cell
proliferation
differentiation,
also
have
antioxidant
properties.
Dietary
important
implications
human
health,
mainly
the
intestinal
maturation
differentiation
development
of
immune
system.
anti-inflammatory
effect
polyamine
can
play
an
role
prevention
chronic
diseases
such
as
cardiovascular
diseases.
In
addition
to
endogenous
synthesis,
food
is
source
polyamines.
Although
there
no
recommendations
for
daily
intake,
it
known
that
stages
rapid
growth
(i.e.,
neonatal
period),
requirements
high.
Additionally,
Frontiers in Nutrition,
Год журнала:
2019,
Номер
6
Опубликована: Март 14, 2019
The
polyamines
putrescine,
spermidine,
and
spermine
are
widely
distributed
polycationic
compounds
essential
for
cellular
functions.
Intracellular
polyamine
pools
tightly
regulated
by
a
complex
regulatory
mechanism
involving
de
novo
biosynthesis,
catabolism,
transport
across
the
plasma
membrane.
In
mammals,
both
production
of
their
uptake
from
extracellular
space
controlled
set
proteins
named
antizymes
antizyme
inhibitors.
Dysregulation
levels
has
been
implicated
in
variety
human
pathologies,
especially
cancer.
Additionally,
decreases
intracellular
circulating
during
aging
have
reported.
differences
content
existing
among
tissues
mainly
due
to
endogenous
metabolism.
addition,
part
tissue
its
origin
diet
or
intestinal
microbiome.
Emerging
evidence
suggested
that
exogenous
(either
orally
administrated
synthetized
gut
microbiota)
able
induce
longevity
mice,
spermidine
supplementation
exerts
cardioprotective
effects
animal
models.
Furthermore,
administration
either
shown
be
effective
improving
glucose
homeostasis
insulin
sensitivity
reducing
adiposity
hepatic
fat
accumulation
diet-induced
obesity
mouse
addition
agmatine,
cationic
molecule
produced
through
arginine
decarboxylation
bacteria
plants,
also
significant
on
metabolism
obese
models,
as
well
effects.
this
review,
we
will
discuss
some
aspects
transport,
how
can
affect
local
levels,
modulation
intake
microbiota
used
potential
therapeutic
purposes.
