Alzheimer’s
disease
(AD),
a
debilitating
neurodegenerative
disorder,
remains
one
of
the
foremost
public
health
challenges
affecting
more
than
30
million
people
worldwide
with
etiology
still
largely
enigmatic.
The
intricate
gut-brain
axis,
serving
as
vital
communication
network
between
gut
and
brain,
appears
to
wield
influence
in
progression
AD.
Our
study
showcases
remarkable
precision
x-ray
phase-contrast
tomography
(XPCT)
conducting
an
advanced
three-dimensional
examination
cellular
composition
structure.
exploitation
micro-
nano-XPCT
on
various
AD
mouse
models
unveiled
relevant
alterations
villi
crypts,
transformations
Paneth
goblet
cells,
along
detection
telocytes,
neurons,
erythrocytes,
mucus
secretion
by
cells
within
cavity.
observed
structural
variations
may
elucidate
transition
from
dysbiosis
neurodegeneration
cognitive
decline.
Leveraging
XPCT
could
prove
pivotal
early
prognosis
disease.
Journal of Huntington s Disease,
Год журнала:
2024,
Номер
13(2), С. 133 - 147
Опубликована: Май 10, 2024
Huntingtin
(HTT)
protein
is
expressed
in
most
cell
lineages,
and
the
toxicity
of
mutant
HTT
multiple
organs
may
contribute
to
neurological
psychiatric
symptoms
observed
Huntington's
disease
(HD).
The
proteostasis
neurotoxicity
are
influenced
by
intracellular
milieu
responses
environmental
signals.
Recent
research
has
highlighted
a
prominent
role
gut
microbiota
brain
immune
system
development,
aging,
progression
disorders.
Several
studies
suggest
that
might
disrupt
homeostasis
(known
as
dysbiosis)
impact
pathogenesis
HD.
Dysbiosis
been
HD
patients,
animal
models
it
coincides
with
aggregation,
abnormal
behaviors,
reduced
lifespan.
This
review
article
aims
highlight
potential
pathways
within
microbiota-gut-immune-central
nervous
(CNS)
axis.
Understanding
functions
Wild-Type
(WT)
these
associated
networks
elucidate
novel
pathogenic
pathways,
identify
biomarkers
peripheral
therapeutic
targets
for
Neurotherapeutics,
Год журнала:
2024,
Номер
21(6), С. e00470 - e00470
Опубликована: Окт. 1, 2024
Multiple
studies
over
the
last
decade
have
established
that
Alzheimer's
disease
and
related
dementias
(ADRD)
are
associated
with
changes
in
gut
microbiome.
These
alterations
organismal
composition
result
abundances
of
functions
encoded
by
microbial
community,
including
metabolic
capabilities,
which
likely
impact
host
mechanisms.
Gut
microbes
access
dietary
components
other
molecules
made
produce
metabolites
can
enter
circulation
cross
blood-brain
barrier
(BBB).
In
recent
years,
several
been
or
shown
to
influence
pathways
relevant
ADRD
pathology.
include
short
chain
fatty
acids,
secondary
bile
tryptophan
derivatives
(such
as
kynurenine,
serotonin,
tryptamine,
indoles),
trimethylamine/trimethylamine
N-oxide.
Notably,
some
these
BBB
various
effects
on
brain,
modulating
release
neurotransmitters
neuronal
function,
inducing
oxidative
stress
inflammation,
impacting
synaptic
function.
Microbial
also
central
nervous
system
through
immune,
enteroendocrine,
enteric
pathways,
perturbations
turn
function
peripheral
immune
responses,
well
integrity,
homeostasis
neurogenesis,
glial
cell
maturation
activation.
This
review
examines
evidence
supporting
notion
is
influenced
microbiota
its
metabolites.
The
potential
therapeutic
advantages
for
preventing
treating
discussed,
highlighting
their
role
developing
new
treatments.
Gut
microbiome
dysbiosis
has
been
widely
implicated
in
cognitive
impairment,
but
the
identity
of
specific
bacterial
taxa
and
mechanisms
are
not
fully
elucidated.
Brain
glucose
hypometabolism
coincides
with
decline.
This
study
explored
link
among
cognition,
gut
microbiota
uptake
based
on
fecal
transplantation
from
mild
impairment
individuals
(MCI-FMT)
investigated
whether
similar
were
involved
27-hydroxycholesterol
(27-OHC)-induced
Our
results
showed
that
MCI-FMT
mice
exhibited
learning
memory
decline
morphological
lesions
brain
colon
tissues.
There
reduced
Alzheimer’s
disease
(AD),
a
debilitating
neurodegenerative
disorder,
remains
one
of
the
foremost
public
health
challenges
affecting
more
than
30
million
people
worldwide
with
etiology
still
largely
enigmatic.
The
intricate
gut-brain
axis,
serving
as
vital
communication
network
between
gut
and
brain,
appears
to
wield
influence
in
progression
AD.
Our
study
showcases
remarkable
precision
x-ray
phase-contrast
tomography
(XPCT)
conducting
an
advanced
three-dimensional
examination
cellular
composition
structure.
exploitation
micro-
nano-XPCT
on
various
AD
mouse
models
unveiled
relevant
alterations
villi
crypts,
transformations
Paneth
goblet
cells,
along
detection
telocytes,
neurons,
erythrocytes,
mucus
secretion
by
cells
within
cavity.
observed
structural
variations
may
elucidate
transition
from
dysbiosis
neurodegeneration
cognitive
decline.
Leveraging
XPCT
could
prove
pivotal
early
prognosis
disease.
