Inflammaging: Implications in Sarcopenia

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(23), С. 15039 - 15039

Опубликована: Ноя. 30, 2022

In a world in which life expectancy is increasing, understanding and promoting healthy aging becomes contemporary demand. the elderly, sterile, chronic low-grade systemic inflammation known as “inflammaging” linked with many age-associated diseases. Considering sarcopenia loss of strength mass skeletal muscle related to aging, correlations between these two terms have been proposed. Better knowledge immune system players would help elucidate their implications sarcopenia. Characterizing activators damage sensors downstream effectors explains inference performance. Sarcopenia has also diseases such diabetes, metabolic syndrome obesity. Implications inflammatory signals from negatively affect muscle. Autophagic mechanisms are closely inflammasome, autophagy eliminates stress signaling sent by organelles, but acts an immunomodulatory function affecting cells cytokine release. The use melatonin, antioxidant, ROS scavenger modulator, or senotherapeutic compounds targeting senescent could represent strategies counteract inflammation. This review aims present factors regulating inflammaging major order understand molecular involved

Язык: Английский

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Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Март 14, 2023

Abstract The ageing process is a systemic decline from cellular dysfunction to organ degeneration, with more predisposition deteriorated disorders. Rejuvenation refers giving aged cells or organisms youthful characteristics through various techniques, such as reprogramming and epigenetic regulation. great leaps in rejuvenation prove that not one-way street, many rejuvenative interventions have emerged delay even reverse the process. Defining mechanism by which roadblocks signaling inputs influence complex programs essential for understanding developing strategies. Here, we discuss intrinsic extrinsic factors counteract cell rejuvenation, targeted core mechanisms involved this Then, critically summarize latest advances state-of-art strategies of rejuvenation. Various methods also provide insights treating specific ageing-related diseases, including reprogramming, removal senescence (SCs) suppression senescence-associated secretory phenotype (SASP), metabolic manipulation, stem cells-associated therapy, dietary restriction, immune heterochronic transplantation, etc. potential applications therapy extend cancer treatment. Finally, analyze detail therapeutic opportunities challenges technology. Deciphering will further into anti-ageing disease treatment clinical settings.

Язык: Английский

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Mediation Role of Recreational Physical Activity in the Relationship between the Dietary Intake of Live Microbes and the Systemic Immune-Inflammation Index: A Real-World Cross-Sectional Study

Nutrients, Год журнала: 2024, Номер 16(6), С. 777 - 777

Опубликована: Март 8, 2024

The main topic of this research is the relationship between dietary intake live microbe-containing (LMC) foods, recreational physical activity (RPA), and systemic immune-inflammation index (SII). This study presented a cohort 26,254 individuals in National Health Nutrition Examination Survey (NHANES), representing an estimated weighted population 193,637,615 United States. Weighted multivariable linear regression models were used consideration multi-stage sampling design. Results: found that medium-LMC foods negatively associated with SII [β (95% CI): −4.807 (−7.752, −1.862), p = 0.002], indicating their was correlated lower levels SII. However, no significant associations low- or high-LMC foods. also explored RPA SII, finding more time spent −0.022 (−0.034, −0.011), < 0.001]. A mediation analysis conducted to investigate role food revealed had notable indirect effect, contributing 6.7% overall change Overall, suggests may have beneficial effects on immune inflammation.

Язык: Английский

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Harmful Free Radicals in Aging: A Narrative Review of Their Detrimental Effects on Health

Indian Journal of Clinical Biochemistry, Год журнала: 2023, Номер 39(2), С. 154 - 167

Опубликована: Авг. 1, 2023

Язык: Английский

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Fiber-Type Shifting in Sarcopenia of Old Age: Proteomic Profiling of the Contractile Apparatus of Skeletal Muscles

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2415 - 2415

Опубликована: Янв. 26, 2023

The progressive loss of skeletal muscle mass and concomitant reduction in contractile strength plays a central role frailty syndrome. Age-related neuronal impairments are closely associated with sarcopenia the elderly, which is characterized by severe muscular atrophy that can considerably lessen overall quality life at old age. Mass-spectrometry-based proteomic surveys senescent human muscles, as well animal models sarcopenia, have decisively improved our understanding molecular cellular consequences fiber-type shifting during aging. This review outlines spectrometric identification proteome-wide changes atrophying focus on proteins potential markers distribution patterns. observed trend fast-to-slow transitions individual muscles aging process most likely linked to preferential susceptibility fast-twitching fibers atrophy. Studies models, including mostly aged rodent confirmed shifting. analysis fast versus slow isoforms key proteins, such myosin heavy chains, light actins, troponins tropomyosins, suggests them suitable bioanalytical tools

Язык: Английский

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The dietary inflammatory index and its association with the prevalence of hypertension: A cross-sectional study

Frontiers in Immunology, Год журнала: 2023, Номер 13

Опубликована: Янв. 18, 2023

Aims We aim to investigate the association of Dietary Inflammatory Index (DII) with prevalence hypertension in a large multiracial population United States. Methods Participants from National Health and Nutrition Examination Survey (NHANES) (1999–2018) were included this cross-sectional study. information was obtained used calculate DII. Blood pressures participants measured by experienced examiners. The NHANES method “stratified multistage probability sampling,” study is weight analysis following analytic guidance. Weight logistic regression adopted Least Absolute Shrinkage Selection Operator (LASSO) carried out screen most important dietary factors associated risk hypertension. Moreover, nomogram model based on key established; receiver operating characteristic (ROC) curve evaluate diagnostic power for screening risk. Results A total 45,023 study, representing 191 million residents had an elevated DII compared those without showed that increment strongly after adjusting confounding factors. model, screened LASSO regression, favorable discriminatory area under (AUC) 78.5% (95% CI: 78.5%–79.3%). sensitivity excluding who received any drug treatment consistent main analysis. Conclusion An For better prevention hypertension, more attention should be paid controlling inflammation.

Язык: Английский

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Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR)

The journal of nutrition health & aging, Год журнала: 2025, Номер 29(1), С. 100401 - 100401

Опубликована: Янв. 1, 2025

Aging, a universal and inevitable process, is characterized by progressive accumulation of physiological alterations functional decline over time, leading to increased vulnerability diseases ultimately mortality as age advances. Lifestyle factors, notably physical activity (PA) exercise, significantly modulate aging phenotypes. Physical exercise can prevent or ameliorate lifestyle-related diseases, extend health span, enhance function, reduce the burden non-communicable chronic including cardiometabolic disease, cancer, musculoskeletal neurological conditions, respiratory well premature mortality. influences cellular molecular drivers biological aging, slowing rates-a foundational aspect geroscience. Thus, PA serves both preventive medicine therapeutic agent in pathological states. Sub-optimal levels correlate with disease prevalence populations. Structured prescriptions should therefore be customized monitored like any other medical treatment, considering dose-response relationships specific adaptations necessary for intended outcomes. Current guidelines recommend multifaceted regimen that includes aerobic, resistance, balance, flexibility training through structured incidental (integrated lifestyle) activities. Tailored programs have proven effective helping older adults maintain their capacities, extending enhancing quality life. Particularly important are anabolic exercises, such Progressive resistance (PRT), which indispensable maintaining improving capacity adults, particularly those frailty, sarcopenia osteoporosis, hospitalized residential aged care. Multicomponent interventions include cognitive tasks hallmarks frailty (low body mass, strength, mobility, level, energy) thus preventing falls optimizing during aging. Importantly, PA/exercise displays characteristics varies between individuals, necessitating personalized modalities tailored conditions. Precision remains significant area further research, given global impact broad effects PA. Economic analyses underscore cost benefits programs, justifying broader integration into care adults. However, despite these benefits, far from fully integrated practice people. Many healthcare professionals, geriatricians, need more incorporate directly patient care, whether settings hospitals, outpatient clinics, Education about use isolated adjunctive treatment geriatric syndromes would do much ease problems polypharmacy widespread prescription potentially inappropriate medications. This intersection prescriptive practices offers promising approach well-being An strategy combines pharmacotherapy optimize vitality independence people whilst minimizing adverse drug reactions. consensus provides rationale promotion, prevention, management strategies Guidelines included dosages efficacy randomized controlled trials. Descriptions beneficial changes, attenuation phenotypes, role disability provided. The sarcopenia, neuropsychological emphasized. Recommendations bridge existing knowledge implementation gaps integrate mainstream Particular attention paid it applies geroscience, inter-individual variability adaptation demonstrated adult cohorts. Overall, this foundation applying current base an population span

Язык: Английский

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Oxidative stress and metabolism meet epigenetic modulation in physical exercise

Free Radical Biology and Medicine, Год журнала: 2024, Номер 213, С. 123 - 137

Опубликована: Янв. 8, 2024

Physical exercise is established as an important factor of health and generally recommended for its positive effects on several tissues, organs, systems. These come from metabolic adaptations that also include oxidative eustress, in which physical activity increases ROS production antioxidant mechanisms, although this depends the intensity exercise. Muscle metabolism through mechanisms such aerobic anaerobic glycolysis, tricarboxylic acid cycle, lipid can produce metabolites co-factors directly impact epigenetic machinery. In review, we clearly reinforce evidence regulates explain how these be regulated by products produced during fact, recent has demonstrated importance epigenetics gene expression changes implicated adaptation after Importantly, intermediates generated continuous, acute, moderate, or strenuous control enzymes, therefore turning off specific programs lead to physiological

Язык: Английский

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Association between oxidative balance score and metabolic syndrome and its components in US adults: a cross-sectional study from NHANES 2011–2018

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Март 13, 2024

Background Metabolic syndrome (MetS) is a global health concern that threatens human well-being. The oxidative balance score (OBS) tool to identify the level of stress correlated with MetS risk. However, association between OBS and its components has not been reported. Methods This cross-sectional study included adult individuals complete data from National Health Nutrition Examination Survey (NHANES) 2011–2018. A weighted logistic regression analysis was conducted total, dietary, lifestyle scores MetS. Subgroup analyses restricted cubic splines were used further explore associations. Results In 10,025 eligible (51.48% males at median age 46 years) included, prevalence 29.98%. fully adjusted model, higher total associated reduced risk (Q3 vs. Q1: odds ratio [OR] = 0.57, 95% confidence interval [CI], 0.46–0.71, p &lt; 0.001; Q4 OR 0.42, CI, 0.33–0.53, P for trend &lt;0.001). Significant differences observed in relationship dietary (continuous OBS: 0.97, 0.96–0.98, continuous 0.61, 0.58–0.64, 0.001), as well negative five (all 0.05). showed marital status modified subgroup (P interaction 0.014). Moreover, nonlinear correlation (including components) found, elucidating associations Restricted demonstrated obviously U-shape (elevated triglyceride blood pressure). Conclusion suggests strong components. Our indicated decreased manner. Hence, may serve an effective marker identifying MetS, indicating predominance more antioxidants.

Язык: Английский

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Oxidative Stress and Cardiovascular Complications in Type 2 Diabetes: From Pathophysiology to Lifestyle Modifications

Antioxidants, Год журнала: 2025, Номер 14(1), С. 72 - 72

Опубликована: Янв. 9, 2025

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that significantly increases the risk of cardiovascular disease, which leading cause morbidity and mortality among diabetic patients. A central pathophysiological mechanism linking T2DM to complications oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production body’s antioxidant defenses. Hyperglycemia in promotes stress through various pathways, including formation advanced glycation end products, activation protein kinase C, mitochondrial dysfunction, polyol pathway. These processes enhance ROS generation, endothelial vascular inflammation, exacerbation damage. Additionally, disrupts nitric oxide signaling, impairing vasodilation promoting vasoconstriction, contributes complications. This review explores molecular mechanisms by pathogenesis disease T2DM. It also examines potential lifestyle modifications, such dietary changes physical activity, reducing mitigating risks this high-risk population. Understanding these critical for developing targeted therapeutic strategies improve outcomes

Язык: Английский

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