Endocrines,
Год журнала:
2025,
Номер
6(2), С. 23 - 23
Опубликована: Май 14, 2025
Background:
Plastic
pollution
driven
by
human
activities
has
become
a
critical
global
issue
for
health.
A
growing
literature
demonstrates
that
micro-
and
nanoplastics
(MNPs)
contain
endocrine-disrupting
chemicals
(EDCs)
other
harmful
compounds
enter
the
body
easily,
acting
as
agonists
or
antagonists
wide
range
of
hormonal
receptors,
promoting
endocrine
toxicity.
Endocrine
disruption
induced
MNPs
occurs
through
aberrant
activation/inhibition
different
signaling
pathways
in
addition
to
directly
interfering
with
balances,
trigger
apoptosis,
oxidative
stress,
inflammation
cells.
However,
date,
molecular
mechanisms
these
contaminants
remain
not
completely
elucidated.
Furthermore,
given
unanimous
consensus
on
negative
impact
health,
several
methodologies
have
been
developed
detect
only
environment
but
also
biological
fluids
tissues.
Results:
This
review
comprehensively
summarizes
emerging
experimental
clinical
evidence
explaining
underlying
toxicity
related
chronic
plastic
relation
system.
In
addition,
illustrates
new
methodological
approaches
samples,
highlighting
employing
complementary
methods
enables
precise
characterization
quantification
MNPs.
Conclusions:
Future
studies
experimental,
epidemiological,
epigenetic,
multi-omics
are
essential
understanding
short
long-term
effects
glands
developing
effective
strategies
mitigate
their
Testicular
aging
is
associated
with
declining
reproductive
health,
but
the
molecular
mechanisms
are
unclear.
Here
we
generate
a
dataset
of
214,369
single-cell
transcriptomes
from
testicular
cells
35
individuals
aged
21–69,
offering
resource
for
studying
and
physiology.
Machine
learning
analysis
reveals
stronger
response
in
somatic
compared
to
germ
cells.
Two
waves
aging-related
changes
identified:
first
peritubular
donors
their
30s,
marked
by
increased
basement
membrane
thickness,
indicating
priming
state
aging.
In
50s,
exhibit
functional
changes,
including
altered
steroid
metabolism
Leydig
immune
responses
macrophages.
Further
analyses
reveal
impact
body
mass
index
on
spermatogenic
capacity
as
age
progresses,
particularly
after
45.
Altogether,
our
findings
illuminate
alterations
during
testis
relationship
index,
providing
foundation
future
research
potential
diagnostic
markers
therapeutic
targets.
To
enhance
understanding
human
testis,
authors
provide
map
characteristics
throughout
lifespan.
Using
samples
donors,
they
identify
two
examine
interactions
between
index.
Journal of Endocrinological Investigation,
Год журнала:
2023,
Номер
46(6), С. 1079 - 1085
Опубликована: Янв. 12, 2023
Abstract
Background
Infertility,
which
is
defined
as
the
inability
to
conceive
after
at
least
12
months
of
regular
unprotected
sexual
intercourses,
affects
about
15–20%
couples
worldwide
and
a
male
factor
involved
in
half
cases.
The
development
assisted
reproductive
technology
(ART)
made
it
possible
also
individuals
affected
from
severe
oligospermia
or
azoospermia.
However,
impact
on
embryo
development,
implantation,
prevalence
chromosomal
abnormalities,
genetic
epigenetic
alterations,
clinical
obstetric
outcomes
still
controversial.
Purpose
This
narrative
review
examines
indications,
minimum
access
criteria,
by
individual
ART
technique
relation
factor.
Frontiers in Public Health,
Год журнала:
2023,
Номер
11
Опубликована: Окт. 10, 2023
The
deleterious
effects
of
chemical
or
non-chemical
endocrine
disruptors
(EDs)
on
male
fertility
potential
is
well
documented
but
still
not
fully
elucidated.
For
example,
the
detection
industrial
chemicals'
metabolites
in
seminal
plasma
and
follicular
fluid
can
affect
efficiency
gametogenesis,
maturation
competency
gametes
has
guided
scientists
to
hypothesize
that
disrupting
chemicals
(EDCs)
may
disrupt
hormonal
homoeostasis
by
leading
a
wide
range
control
impairments.
EDCs
exposure
reproductive
health
are
highly
dependent
factors
including
type
EDCs,
duration
exposure,
individual
susceptibility,
presence
other
co-factors.
Research
continue
study
these
complex
interactions.
aim
this
review
summarize
literature
better
understand
risks
France.
Human Reproduction,
Год журнала:
2023,
Номер
38(10), С. 1861 - 1871
Опубликована: Авг. 10, 2023
In
modern
post-transition
societies,
we
are
reproducing
later
and
living
longer.
While
the
impact
of
age
on
female
reproductive
function
has
been
well
studied,
much
less
is
known
about
intersection
male
reproduction.
Our
current
understanding
that
advancing
brings
forth
a
progressive
decline
in
fertility
accompanied
by
reduction
circulating
testosterone
levels
appearance
age-dependent
pathologies
including
benign
prostatic
hypertrophy
erectile
dysfunction.
Paternal
ageing
also
associated
with
profound
increase
sperm
DNA
damage,
multiple
epigenetic
changes
germ
line
an
elevated
mutational
load
offspring.
The
net
result
such
disease
burden
carried
progeny
males,
dominant
genetic
diseases
as
Apert
syndrome
achondroplasia,
neuropsychiatric
conditions
autism
spontaneous
schizophrenia.
basis
these
age-related
effects
appears
to
involve
two
fundamental
mechanisms.
first
positive
selection
mechanism
whereby
stem
cells
containing
mutations
mitogen-activated
protein
kinase
pathway
gain
selective
advantage
over
their
non-mutant
counterparts
exhibit
significant
clonal
expansion
passage
time.
second
dependent
oxidative
stress
which
impairs
steroidogenic
capacity
Leydig
cells,
disrupts
ability
Sertoli
support
normal
differentiation
functional
integrity
spermatozoa.
Given
central
importance
defining
chronological
reproduction,
there
may
be
role
for
antioxidants
clinical
management
this
process.
animal
studies
supportive
strategy,
carefully
designed
trials
now
needed
if
realize
therapeutic
potential
approach
context.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(10), С. 2731 - 2731
Опубликована: Май 7, 2024
As
global
demographics
shift
toward
increasing
paternal
age,
the
realm
of
assisted
reproductive
technologies
(ARTs),
particularly
in
vitro
fertilization
(IVF)
and
intracytoplasmic
sperm
injection
(ICSI),
faces
new
challenges
opportunities.
This
study
provides
a
comprehensive
exploration
implications
advanced
age
on
ART
outcomes.
Background
research
highlights
social,
cultural,
economic
factors
driving
men
later
fatherhood,
with
focus
impact
delayed
paternity
Methods
involve
thorough
review
existing
literature,
centering
changes
testicular
function,
semen
quality,
genetic
epigenetic
shifts
associated
advancing
age.
Study
results
point
to
intricate
associations
between
father’s
outcomes,
older
being
linked
diminished
potential
risks,
varied
impacts
embryo
implantation
rates,
birth
The
conclusions
drawn
from
current
suggest
that
while
presents
certain
risks
challenges,
understanding
mitigating
these
through
strategies
such
as
cryopreservation,
lifestyle
modifications,
preimplantation
testing
can
optimize
Future
directions
are
identified
further
comprehend
mechanisms
long-term
effects
father
offspring
health.
underscores
need
for
approach
navigating
intricacies
fatherhood
within
context
ART,
aiming
best
possible
outcomes
couples
their
children.
Journal of Clinical Medicine,
Год журнала:
2023,
Номер
12(15), С. 4928 - 4928
Опубликована: Июль 27, 2023
Advanced
age
has
been
reported
to
negatively
affect
sperm
parameters
and
spermatozoa
DNA
integrity.
A
decline
in
criteria
was
also
associated
with
altered
epigenetic
marks
such
as
methylation
a
potential
downstream
impact
on
vitro
fertilization
success
clinical
outcomes.
The
aim
of
the
present
retrospective
study
clarify
association
between
advanced
paternal
(APA)
parameters,
integrity
profile.
total
671
patients
consulting
for
infertility
underwent
analysis,
assessment
level
measurement.
principal
finding
that
individuals
over
40
years
exhibit
significant
increase
fragmentation
levels
compared
younger
group
(15%
versus
9%,
respectively,
Genes,
Год журнала:
2024,
Номер
15(5), С. 539 - 539
Опубликована: Апрель 25, 2024
Male
fertility
can
be
affected
by
oxidative
stress
(OS),
which
occurs
when
an
imbalance
between
the
production
of
reactive
oxygen
species
(ROS)
and
body's
ability
to
neutralize
them
arises.
OS
damage
cells
influence
sperm
production.
High
levels
lipid
peroxidation
have
been
linked
reduced
motility
decreased
fertilization
ability.
This
literature
review
discusses
most
commonly
used
biomarkers
measure
caused
ROS,
such
as
high
level
in
seminal
plasma
indicator
antioxidant
activity.
The
investigated
include
8-hydroxy-2-deoxyguanosine
acid
(8-OHdG),
a
marker
DNA
F2
isoprostanoids
(8-isoprostanes)
produced
peroxidation.
Furthermore,
this
focuses
on
recent
methodologies
including
NGS
polymorphisms
differentially
expressed
gene
(DEG)
analysis,
well
epigenetic
mechanisms
ROS
during
spermatogenesis
along
with
new
developed
evaluate
biomarkers.
Finally,
addresses
valuable
insight
into
male
infertility
provided
these
advances
how
they
led
treatment
possibilities.
Overall,
use
has
supplied
innovative
diagnostic
therapeutic
approaches,
enhancing
our
understanding
mechanisms.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(8), С. 7224 - 7224
Опубликована: Апрель 13, 2023
This
systematic
review
and
meta-analysis
summarize
the
difference
in
methylation
of
H19
gene
patients
with
abnormal
versus
normal
conventional
sperm
parameters.
It
also
evaluates
effects
age
concentration
on
spermatozoa
using
meta-regression
analysis.
was
performed
according
to
MOOSE
guidelines
for
meta-analyses
Systematic
Reviews
Observational
Studies
Preferred
Reporting
Items
Review
Meta-Analysis
Protocols
(PRISMA-P).
The
quality
evidence
reported
studies
included
assessed
Cambridge
Quality
Checklists.
A
total
11
articles
met
our
inclusion
criteria.
Quantitative
analysis
showed
that
levels
were
significantly
lower
group
infertile
than
fertile
controls.
reduction
much
more
pronounced
oligozoospermia
(alone
or
associated
other
parameter
abnormalities)
those
recurrent
pregnancy
loss.
Meta-regression
results
be
independent
both
patient
concentration.
Therefore,
pattern
should
evaluated
among
couples
accessing
assisted
reproductive
techniques
(ART),
order
gain
prognostic
information
ART
outcome
offspring
health.
Animal Reproduction,
Год журнала:
2023,
Номер
20(2)
Опубликована: Янв. 1, 2023
Paternal
programming
is
the
concept
that
environmental
signals
from
sire's
experiences
leading
up
to
mating
can
alter
semen
and
ultimately
affect
phenotype
of
resulting
offspring.
Potential
mechanisms
carrying
paternal
effects
offspring
be
associated
with
epigenetic
signatures
(DNA
methylation,
histone
modification
non-coding
RNAs),
oxidative
stress,
cytokines,
seminal
microbiome.
Several
opportunities
exist
for
sperm/semen
influenced
during
development;
these
are
within
testicle,
epididymis,
or
accessory
sex
glands.
Epigenetic
sperm
impacted
pre-natal
pre-pubertal
periods,
sexual
maturity
advancing
sire
age.
Sperm
susceptible
alterations
as
dictated
by
their
developmental
stage
at
time
perturbation,
plasma
likely
have
both
dependent
independent
on
Research
using
rodent
models
has
revealed
many
factors
including
over/under
nutrition,
dietary
fat,
protein,
ingredient
composition
(e.g.,
macro-
micronutrients),
exercise,
exposure
drugs,
alcohol,
endocrine
disruptors
all
elicit
responses
evident
in
phenotype.
livestock
species
also
age,
fertility
level,
plane
heat
stress
induce
epigenetic,
cytokine,
microbiome
profiles
and/or
plasma.
In
addition,
recent
findings
pigs,
sheep,
cattle
indicated
blastocysts
post-fertilization
some
continuing
into
post-natal
life
Our
research
group
focused
understanding
common
management
scenarios
nutrition
growth
rates
bulls
rams
subsequent
outcomes.
Understanding
implication
imperative
short-term
feeding
decisions
potential
impact
productivity
profitability
our
herds
generations
come.
