Interleukins in cancer: from biology to therapy

Nature reviews. Cancer, Год журнала: 2021, Номер 21(8), С. 481 - 499

Опубликована: Июнь 3, 2021

Язык: Английский

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Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

Journal of Hematology & Oncology, Год журнала: 2022, Номер 15(1)

Опубликована: Июнь 28, 2022

Abstract Cancer is one of the leading causes death worldwide, and factors responsible for its progression need to be elucidated. Exosomes are structures with an average size 100 nm that can transport proteins, lipids, nucleic acids. This review focuses on role exosomes in cancer therapy. We discuss how able modulate components tumor microenvironment influence proliferation migration rates cells. also highlight that, depending their cargo, suppress or promote cell enhance reduce response radio- chemo-therapies. In addition, we describe trigger chronic inflammation lead immune evasion by focusing ability transfer non-coding RNAs between cells other molecular signaling pathways such as PTEN PI3K/Akt cancer. Subsequently, use carriers anti-tumor agents genetic tools control progression. then tumor-derived carcinogenesis. Finally, devote a section study diagnostic prognostic clinical courses important treatment patients. provides comprehensive understanding therapy, therapeutic value remodeling microenvironment. Graphical

Язык: Английский

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Cytokine Networks in the Pathogenesis of Rheumatoid Arthritis

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(20), С. 10922 - 10922

Опубликована: Окт. 10, 2021

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic inflammation causing progressive joint damage that can lead to lifelong disability. The pathogenesis of RA involves a complex network various cytokines and cells trigger synovial cell proliferation cause both cartilage bone. Involvement the tumor necrosis factor (TNF)-α interleukin (IL)-6 central RA, but recent research has revealed other such as IL-7, IL-17, IL-21, IL-23, granulocyte macrophage colony-stimulating (GM-CSF), IL-1β, IL-18, IL-33, IL-2 also play role. Clarification pathology led development therapeutic agents biological disease-modifying anti-rheumatic drugs (DMARDs) Janus kinase (JAK) inhibitors, further details immunological background are emerging. This review covers existing knowledge regarding roles cytokines, related immune system in manipulation which may offer potential for even safer more effective treatments future.

Язык: Английский

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M1/M2 macrophages and their overlaps – myth or reality?

Clinical Science, Год журнала: 2023, Номер 137(15), С. 1067 - 1093

Опубликована: Авг. 1, 2023

Abstract Macrophages represent heterogeneous cell population with important roles in defence mechanisms and homoeostasis. Tissue macrophages from diverse anatomical locations adopt distinct activation states. M1 M2 are two polarized forms of mononuclear phagocyte vitro differentiation phenotypic patterns functional properties, but vivo, there is a wide range different macrophage phenotypes between depending on the microenvironment natural signals they receive. In human infections, pathogens use strategies to combat these include shaping polarization towards one or another phenotype. infiltrating tumours can affect patient’s prognosis. have been shown promote tumour growth, while provide both tumour-promoting anti-tumour properties. autoimmune diseases, prolonged activation, as well altered function contribute their onset activity. atherosclerotic lesions, expressing profiles detected potential factors affecting occurrence cardiovascular diseases. allergic inflammation, T2 cytokines drive profiles, which airway inflammation remodelling. transplantations seem acute rejection, fibrosis graft. The view pro-inflammatory suppressing seems be an oversimplification because cells exploit very high level plasticity large scale immunophenotypes overlapping this respect, it would more precise describe M1-like M2-like.

Язык: Английский

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Molecular mechanisms of ferroptosis and relevance to inflammation

Inflammation Research, Год журнала: 2022, Номер 72(2), С. 281 - 299

Опубликована: Дек. 19, 2022

Язык: Английский

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Crosstalk of Inflammatory Cytokines within the Breast Tumor Microenvironment

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 4002 - 4002

Опубликована: Фев. 16, 2023

Several immune and immunocompetent cells, including dendritic macrophages, adipocytes, natural killer T B are significantly correlated with the complex discipline of oncology. Cytotoxic innate adaptive cells can block tumor proliferation, others prevent system from rejecting malignant provide a favorable environment for progression. These communicate microenvironment through cytokines, chemical messenger, in an endocrine, paracrine, or autocrine manner. cytokines play important role health disease, particularly host responses to infection inflammation. They include chemokines, interleukins (ILs), adipokines, interferons, colony-stimulating factors (CSFs), necrosis factor (TNF), which produced by wide range such as B-cells, T-cells, mast well endothelial fibroblasts, variety stromal some cancer cells. Cytokines crucial cancer-related inflammation, direct indirect effects on antagonistic promoting functions. have been extensively researched immunostimulatory mediators promote generation, migration recruitment that contribute effective antitumor response pro-tumor microenvironment. Thus, many cancers breast cancer, leptin, IL-1B, IL-6, IL-8, IL-23, IL-17, IL-10 stimulate while IL-2, IL-12, IFN-γ, inhibit proliferation and/or invasion enhance body's anti-tumor defense. Indeed, multifactorial functions tumorigenesis will advance our understanding cytokine crosstalk pathways microenvironment, JAK/STAT, PI3K, AKT, Rac, MAPK, NF-κB, JunB, cFos, mTOR, involved angiogenesis, metastasis. Accordingly, targeting blocking tumor-promoting activating amplifying tumor-inhibiting considered cancer-directed therapies. Here, we focus inflammatory pro- responses, discuss anti-cancer therapeutic applications.

Язык: Английский

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The Role of Inflammation in CKD

Cells, Год журнала: 2023, Номер 12(12), С. 1581 - 1581

Опубликована: Июнь 7, 2023

Chronic kidney disease (CKD) affects many adults worldwide. Persistent low-grade inflammation is a substantial factor in its development and progression has correlated with increased mortality cardiovascular problems. This product of dysregulation the normal balance between pro- anti-inflammatory markers. Various factors such as innate immune system activation, reactive oxygen species production, periodontal disease, systems intestinal dysbiosis result this balance. Furthermore, down-effects hypertension, renal fibrosis acceleration function decline. Moreover, over time been linked to malignancy CKD. As CKD progresses, patients require dialysis, which negative bidirectional relationship persistent inflammation. Treatment options for are vast, including cytokine inhibitors, statins diets. However, more research needed create standardized management plan. In review, we will examine physiology system. We then delve into pathology behind inflammation, various causes downstream effects dialysis potential treatments

Язык: Английский

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Chronic inflammation, cancer development and immunotherapy

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Окт. 14, 2022

Chronic inflammation plays a pivotal role in cancer development. Cancer cells interact with adjacent cellular components (pro-inflammatory cells, intrinsic immune stromal etc.) and non-cellular to form the inflammatory tumor microenvironment (TME). Interleukin 6 (IL-6), macrophage migration inhibitory factor (MIF), checkpoint factors other pro-inflammatory cytokines produced by TME are main mediators of intercellular communication TME, which link chronic stimulating different oncogenic signaling pathways improving escape promote In parallel, ability monocytes, T regulatory (Tregs) B (Bregs) perform homeostatic tolerogenic functions is hijacked leading local or systemic immunosuppression. Standard treatments for advanced malignancies such as chemotherapy radiotherapy have improved last decades. However, clinical outcomes certain malignant cancers not satisfactory due drug resistance side effects. The application therapy (ICT) has brought hope treatment, although therapeutic efficacy still limited immunosuppressive microenvironment. Emerging evidences reveal that ideal therapies including clearance disruption tumor-induced immunosuppression targeting suppressive well reactivation anti-tumor ICT. Here, we review impacts major their downstream molecules on We also discuss important management cancer.

Язык: Английский

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Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis

Science Immunology, Год журнала: 2023, Номер 8(80)

Опубликована: Фев. 3, 2023

Neutrophils, the most abundant innate immune cells, function as crucial regulators of adaptive system in diverse pathological conditions, including metastatic cancer. However, it remains largely unknown whether their immunomodulatory functions are intrinsic or acquired within tissue environment. Here, using mouse models breast cancer lungs, we show that, although neutrophils isolated from bone marrow (BM) blood minimally immunosuppressive, lung-infiltrating robustly suppressive both T cells and natural killer (NK) cells. We found that this tissue-specific immunosuppressive capacity exists steady state is reinforced by tumor-associated inflammation. Acquisition potent immunosuppression activity was endowed lung-resident stroma, specifically CD140a + mesenchymal (MCs) via prostaglandin-endoperoxide synthase 2 (PTGS2), rate-limiting enzyme for prostaglandin E (PGE ) biosynthesis. MC-specific deletion Ptgs2 pharmacological inhibition PGE receptors reversed lung neutrophil–mediated mitigated metastasis vivo. These stroma–targeting strategies substantially improved therapeutic efficacy adoptive cell–based immunotherapy treating disease mice. Collectively, our results reveal immunoregulatory effects induced tissue-resident stroma targeting stromal factors represents an effective approach to boost immunity against disease.

Язык: Английский

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Targeting cytokine and chemokine signaling pathways for cancer therapy

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Июль 22, 2024

Abstract Cytokines are critical in regulating immune responses and cellular behavior, playing dual roles both normal physiology the pathology of diseases such as cancer. These molecules, including interleukins, interferons, tumor necrosis factors, chemokines, growth factors like TGF-β, VEGF, EGF, can promote or inhibit growth, influence microenvironment, impact efficacy cancer treatments. Recent advances targeting these pathways have shown promising therapeutic potential, offering new strategies to modulate system, progression, overcome resistance conventional therapies. In this review, we summarized current understanding implications cytokine chemokine signaling By exploring molecules biology response, highlighted development novel agents aimed at modulating combat The review elaborated on nature cytokines promoters suppressors tumorigenesis, depending context, discussed challenges opportunities presents for intervention. We also examined latest advancements targeted therapies, monoclonal antibodies, bispecific receptor inhibitors, fusion proteins, engineered variants, their metastasis, microenvironment. Additionally, evaluated potential combining therapies with other treatment modalities improve patient outcomes. Besides, focused ongoing research clinical trials that pivotal advancing our application cytokine- chemokine-targeted patients.

Язык: Английский

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