Journal of Ethnopharmacology, Год журнала: 2023, Номер 310, С. 116402 - 116402
Опубликована: Март 24, 2023
Язык: Английский
Cell Host & Microbe, Год журнала: 2023, Номер 31(5), С. 798 - 810.e7
Опубликована: Апрель 12, 2023
Язык: Английский
Процитировано
67
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Фев. 9, 2023
Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation, pannus formation, and bone cartilage damage. It has a high disability rate. The hypoxic microenvironment of RA joints can cause reactive oxygen species (ROS) accumulation mitochondrial damage, which not only affect the metabolic processes immune cells pathological changes in fibroblastic but also upregulate expression several inflammatory pathways, ultimately promoting inflammation. Additionally, ROS damage are involved angiogenesis destruction, thereby accelerating progression. In this review, we highlighted effects on response, angiogenesis, RA. summarized therapies that target or mitochondria to relieve symptoms discuss gaps research existing controversies, hoping provide new ideas for area insights targeted drug development
Язык: Английский
Процитировано
63
Pharmaceutics, Год журнала: 2023, Номер 15(1), С. 229 - 229
Опубликована: Янв. 10, 2023
Curcumin (CUR) is a polyphenol extracted from the rhizome of Curcuma longa that possesses potent anti-inflammatory and antioxidant potential. Despite CUR’s numerous beneficial effects on human health, it has limitations, such as poor absorption. Nano-based drug delivery systems have recently been applied to improve solubility bioavailability potentialize its health effects. This review investigated different CUR-based nanomedicines inflammatory immunomodulated diseases. PUBMED, EMBASE, COCHRANE, GOOGLE SCHOLAR databases were searched, Scale for Assessment Narrative Review Articles (SANRA) was used quality assessment PRISMA guidelines. Overall, 66 studies included comprising atherosclerosis, rheumatoid arthritis (RA), Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS), Huntington’s (HD), bowel diseases (IBD), psoriasis, liver fibrosis, epilepsy, COVID-19. The available scientific show there are many known nanoformulations with curcumin. They can be found in nanosuspensions, nanoparticles, nanoemulsions, solid lipid particles, nanocapsules, nanospheres, liposomes. These formulations CUR effectively adjuvants several immune-mediated atheroma plaque formation, RA, dementia, AD, PD, MS, IBD, COVID-19, anti-fibrotic fibrotic disease.
Язык: Английский
Процитировано
52
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Окт. 4, 2023
Autoimmune diseases (AIDs) are immune disorders whose incidence and prevalence increasing year by year. AIDs produced the system’s misidentification of self-antigens, seemingly caused excessive function, but in fact they result reduced accuracy due to decline system which cannot clearly identify foreign invaders thus issuing false attacks, eventually leading disease. The occurrence is often accompanied emergence inflammation, inflammatory mediators (inflammatory factors, inflammasomes) play an important role pathogenesis AIDs, mediate process affecting innate cells (such as macrophages) adaptive T B cells), ultimately promote autoimmune responses, so targeting mediators/pathways one emerging treatment strategies AIDs. This review will briefly describe inflammation different give a rough introduction inhibitors hoping have reference significance for subsequent options
Язык: Английский
Процитировано
52
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Май 15, 2023
Bile acids (BAs) as cholesterol-derived molecules play an essential role in some physiological processes such nutrient absorption, glucose homeostasis and regulation of energy expenditure. They are synthesized the liver primary BAs cholic acid (CA), chenodeoxycholic (CDCA) conjugated forms. A variety secondary deoxycholic (DCA) lithocholic (LCA) their derivatives is intestine through involvement various microorganisms. In addition to functions, metabolites also involved differentiation functions innate adaptive immune cells macrophages (Macs), dendritic (DCs), myeloid derived suppressive (MDSCs), regulatory T (Treg), Breg cells, helper (Th)17 CD4 Th1 Th2 CD8 B NKT cells. Dysregulation affects development diseases inflammatory bowel diseases. We here summarize recent advances how maintain gut systemic homeostasis, including metabolism derivatives, function effects on immune-associated disorders.
Язык: Английский
Процитировано
48
Acta Pharmaceutica Sinica B, Год журнала: 2023, Номер 13(11), С. 4417 - 4441
Опубликована: Май 26, 2023
Rheumatoid arthritis is a chronic, systemic autoimmune disease predominantly based on joint lesions with an extremely high disability and deformity rate. Several drugs have been used for the treatment of rheumatoid arthritis, but their use limited by suboptimal bioavailability, serious adverse effects, nonnegligible first-pass effects. In contrast, transdermal drug delivery systems (TDDSs) can avoid these drawbacks improve patient compliance, making them promising option (RA). Of course, TDDSs also face unique challenges, as physiological barrier skin makes somewhat limited. To overcome this maximize efficiency, evolved in terms principle facilitation technology, different generations derived, which significantly improved efficiency even achieved individualized controlled delivery. review, we summarize systems, corresponding strategies, applications RA.
Язык: Английский
Процитировано
43
MedComm, Год журнала: 2024, Номер 5(3)
Опубликована: Март 1, 2024
Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the unresolved synovial inflammation for tissues‐destructive consequence, which remains one of significant causes disability and labor loss, affecting about 0.2–1% global population. Although treatments with disease‐modifying antirheumatic drugs (DMARDs) are effective to control decrease bone destruction, overall remission rates RA still stay at low level. Therefore, uncovering pathogenesis expediting clinical transformation imminently in need. Here, we summarize immunological basis, inflammatory pathways, genetic epigenetic alterations, metabolic disorders RA, highlights on abnormality immune cells atlas, epigenetics, immunometabolism. Besides an overview first‐line medications including conventional DMARDs, biologics, small molecule agents, discuss depth promising targeted therapies under or preclinical trials, especially regulators. Additionally, prospects precision medicine based biopsy RNA‐sequencing cell mesenchymal stem chimeric antigen receptor T‐cell also looked forward. The advancements innovations accelerates progress treatments.
Язык: Английский
Процитировано
25
Journal of Functional Biomaterials, Год журнала: 2025, Номер 16(1), С. 24 - 24
Опубликована: Янв. 14, 2025
Autoimmune diseases present complex therapeutic challenges due to their chronic nature, systemic impact, and requirement for precise immunomodulation avoid adverse side effects. Recent advancements in biodegradable stimuli-responsive nanomaterials have opened new avenues targeted drug delivery systems capable of addressing these challenges. This review provides a comprehensive analysis state-of-the-art nanocarriers such as polymeric nanoparticles, liposomes, hydrogels engineered autoimmune therapies. These are designed degrade safely the body while releasing agents response specific stimuli, including pH, temperature, redox conditions, enzymatic activity. By achieving localized controlled release anti-inflammatory immunosuppressive agents, minimize toxicity enhance efficacy. We discuss underlying mechanisms nanomaterials, recent applications treating rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, design considerations essential clinical translation. Additionally, we address current challenges, biocompatibility, scalability, regulatory hurdles, well future directions integrating advanced nanotechnology with personalized medicine treatment. highlights transformative potential presenting them promising strategy advance precision improve patient outcomes disease management.
Язык: Английский
Процитировано
2
Journal of Controlled Release, Год журнала: 2022, Номер 348, С. 42 - 56
Опубликована: Июнь 2, 2022
Язык: Английский
Процитировано
49
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(6), С. 3374 - 3374
Опубликована: Март 21, 2022
CD8+ T lymphocytes are a heterogeneous class of cells that play crucial role in the adaptive immune response against pathogens and cancer. During their lifetime, they acquire cytotoxic functions to ensure clearance infected or transformed and, addition, turn into memory lymphocytes, thus providing long-term protection. ageing, thymic involution causes reduction circulating an enrichment cells, partially explaining lowering towards novel antigens with implications vaccine efficacy. Moreover, persistent stimulation by several throughout life favors switching senescent phenotype contributing low-grade inflammation is major component ageing-related diseases. In genetically predisposed young people, immunological stress caused viral infections (e.g., HIV, CMV, SARS-CoV-2), autoimmune disorders tumor microenvironment (TME) could mimic ageing status consequent acceleration cell senescence. This, turn, exacerbates inflamed conditions dramatic effects on clinical progression disease. A better characterization as well can be pivotal prevent age-related diseases, improve strategies possibly, immunotherapies diseases
Язык: Английский
Процитировано
42