Autophagy and cancer drug resistance in dialogue: Pre-clinical and clinical evidence

Cancer Letters, Год журнала: 2023, Номер 570, С. 216307 - 216307

Опубликована: Июль 12, 2023

Язык: Английский

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Tumor biomarkers for diagnosis, prognosis and targeted therapy

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Май 20, 2024

Abstract Tumor biomarkers, the substances which are produced by tumors or body’s responses to during tumorigenesis and progression, have been demonstrated possess critical encouraging value in screening early diagnosis, prognosis prediction, recurrence detection, therapeutic efficacy monitoring of cancers. Over past decades, continuous progress has made exploring discovering novel, sensitive, specific, accurate tumor significantly promoted personalized medicine improved outcomes cancer patients, especially advances molecular biology technologies developed for detection biomarkers. Herein, we summarize discovery development including history conventional innovative used biomarker classification biomarkers based on tissue origins, application clinical management. In particular, highlight recent advancements biomarker-based anticancer-targeted therapies emerging as breakthroughs promising strategies. We also discuss limitations challenges that need be addressed provide insights perspectives turn into opportunities this field. Collectively, multiple emphasized review may guidance precision medicine, broaden horizons future research directions, expedite patients according their rather than organs origin.

Язык: Английский

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Nanomaterials in tumor immunotherapy: new strategies and challenges

Molecular Cancer, Год журнала: 2023, Номер 22(1)

Опубликована: Июнь 13, 2023

Abstract Tumor immunotherapy exerts its anti-tumor effects by stimulating and enhancing immune responses of the body. It has become another important modality therapy with significant clinical efficacy advantages compared to chemotherapy, radiotherapy targeted therapy. Although various kinds tumor immunotherapeutic drugs have emerged, challenges faced in delivery these drugs, such as poor permeability low cell uptake rate, had prevented their widespread application. Recently, nanomaterials emerged a means for treatment different diseases due targeting properties, biocompatibility functionalities. Moreover, possess characteristics that overcome defects traditional immunotherapy, large drug loading capacity, precise easy modification, thus leading wide application immunotherapy. There are two main classes novel nanoparticles mentioned this review: organic (polymeric nanomaterials, liposomes lipid nanoparticles) inorganic (non-metallic metallic nanomaterials). Besides, fabrication method nanoparticles, Nanoemulsions, was also introduced. In summary, review article mainly discussed research progress based on past few years offers theoretical basis exploring strategies future.

Язык: Английский

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Wnt/β-catenin-driven EMT regulation in human cancers

Cellular and Molecular Life Sciences, Год журнала: 2024, Номер 81(1)

Опубликована: Фев. 9, 2024

Abstract Metastasis accounts for 90% of cancer-related deaths among the patients. The transformation epithelial cells into mesenchymal with molecular alterations can occur during epithelial–mesenchymal transition (EMT). EMT mechanism accelerates cancer metastasis and drug resistance ability in human cancers. Among different regulators EMT, Wnt/β-catenin axis has been emerged as a versatile modulator. Wnt is active form physiological condition due to function GSK-3β that destructs β-catenin, while ligand–receptor interaction impairs increase β-catenin stability promote its nuclear transfer. Regarding oncogenic Wnt/β-catenin, upregulation occurs cancers it accelerate EMT-mediated resistance. stimulation by binding ligands Frizzled receptors enhance accumulation cytoplasm stimulates related genes upon translocation. Wnt/β-catenin/EMT implicated augmenting both solid hematological tumors. Wnt/EMT-mediated promotes malignant behavior tumor cells, causing therapy be modulated upstream mediators which non-coding RNAs are main regulators. Moreover, pharmacological intervention, mainly using phytochemicals, suppresses Wnt/EMT suppression. Graphical abstract

Язык: Английский

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Exosomal circular RNAs: A chief culprit in cancer chemotherapy resistance

Drug Resistance Updates, Год журнала: 2023, Номер 67, С. 100937 - 100937

Опубликована: Фев. 2, 2023

Язык: Английский

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EMT mechanism in breast cancer metastasis and drug resistance: Revisiting molecular interactions and biological functions

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 155, С. 113774 - 113774

Опубликована: Окт. 3, 2022

One of the malignant tumors in women that has involved both developed and developing countries is breast cancer. Similar to other types tumors, cancer cells demonstrate high metastatic nature. Besides, tumor have ability drug resistance. EMT related mechanism metastasis focus current manuscript highlighting function malignancy Breast increase their migration by induction During EMT, N-cadherin vimentin levels increase, E-cadherin decrease mediate EMT-induced invasion. Different kinds anti-cancer agents such as tamoxifen, cisplatin paclitaxel mediates chemoresistance feature cells. Furthermore, correlates with radio-resistance tumor. Clinical aspect reversing preventing chemotherapy or radiotherapy failure patients improving survival time. The anti-tumor suppress can be used for decreasing invasion increasing chemosensitivity lncRNAs, miRNAs factors modulate progression are discussed here.

Язык: Английский

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Exosomal circRNA: emerging insights into cancer progression and clinical application potential

Journal of Hematology & Oncology, Год журнала: 2023, Номер 16(1)

Опубликована: Июнь 26, 2023

Abstract Exosomal circRNA serves a novel genetic information molecule, facilitating communication between tumor cells and microenvironmental cells, such as immune fibroblasts, other components, thereby regulating critical aspects of cancer progression including escape, angiogenesis, metabolism, drug resistance, proliferation metastasis. Interestingly, microenvironment have new findings in influencing escape mediated by the release exosomal circRNA. Given intrinsic stability, abundance, broad distribution circRNAs, they represent excellent diagnostic prognostic biomarkers for liquid biopsy. Moreover, artificially synthesized circRNAs may open up possibilities therapy, potentially bolstered nanoparticles or plant exosome delivery strategies. In this review, we summarize functions underlying mechanisms cell non-tumor cell-derived progression, with special focus on their roles immunity metabolism. Finally, examine potential application therapeutic targets, highlighting promise clinical use.

Язык: Английский

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Current understanding of plant-derived exosome-like nanoparticles in regulating the inflammatory response and immune system microenvironment

Pharmacological Research, Год журнала: 2023, Номер 190, С. 106733 - 106733

Опубликована: Март 15, 2023

Natural compounds are widely used to prevent and treat various diseases due their antioxidant anti-inflammatory effects. As a kind of promising natural compound, plant-derived exosome-like nanoparticles (PELNs) extracted from multivesicular bodies edible plants, including vegetables, foods, fruits, mainly regulate the cellular immune response pathogen attacks. Moreover, PELNs could remarkably interfere with dynamic imbalance between pro-inflammatory effects, facilitating maintain homeostasis microenvironment. may serve as better alternative animal-derived exosomes (ADEs) owing widespread sources, cost-effectiveness, easy accessibility. can mediate interspecies communication by transferring cargoes such proteins, lipids, nucleic acids plant cells mammalian cells. This review summarizes biogenesis, composition, classification exosomes; common separation, purification, characterization methods PELNs, potential advantages over ADEs; immunomodulatory functions in colitis, cancer, inflammation-associated metabolic diseases. Additionally, future perspectives challenges associated clinical application discussed.

Язык: Английский

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Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges

Pharmacological Research, Год журнала: 2022, Номер 187, С. 106553 - 106553

Опубликована: Ноя. 16, 2022

Cancer progression results from activation of various signaling networks. Among these, PI3K/Akt contributes to proliferation, invasion, and inhibition apoptosis. Hepatocellular carcinoma (HCC) is a primary liver cancer with high incidence rate, especially in regions prevalence viral hepatitis infection. Autoimmune disorders, diabetes mellitus, obesity, alcohol consumption, inflammation can also lead initiation development HCC. The treatment HCC depends on the identification oncogenic factors that tumor cells develop resistance therapy. present review article focuses role progression. Activation promotes glucose uptake, favors glycolysis increases cell proliferation. It inhibits both apoptosis autophagy while promoting survival. stimulates epithelial-to-mesenchymal transition (EMT) matrix-metalloproteinase (MMP) expression during metastasis. In addition increasing colony formation capacity facilitating spread cells, angiogenesis. Therefore, silencing prevents aggressive behavior. confer drug resistance, particularly sorafenib, decreases radio-sensitivity cells. Anti-cancer agents, like phytochemicals small molecules suppress by limiting Being upregulated tissues clinical samples, be used as biomarker predict patients' response

Язык: Английский

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Progress in targeting PTEN/PI3K/Akt axis in glioblastoma therapy: Revisiting molecular interactions

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 158, С. 114204 - 114204

Опубликована: Янв. 4, 2023

Glioblastoma (GBM) is one of the most malignant cancers central nervous system and due to its sensitive location, surgical resection has high risk therefore, chemotherapy radiotherapy are utilized for treatment. However, chemoresistance radio-resistance other problems in GBM Hence, new therapies based on genes recommended treatment GBM. PTEN a tumor-suppressor operator cancer that inhibits PI3K/Akt/mTOR axis diminishing growth, metastasis drug resistance. In current review, function PTEN/PI3K/Akt progression evaluated. Mutation or depletion leads increase progression. Low expression level mediates poor prognosis by increasing proliferation invasion, promotes malignancy tumor cells. Moreover, loss signaling can result therapy resistance Activation impairs metabolism via glycolysis inhibition. contrast PTEN, PI3K/Akt oncogenic during progression, enhances. shows positive association with pathways similar signaling, regulated non-coding RNAs. upregulation inhibition anti-cancer agents be beneficial interfering This review emphasizes networks related provides insights targeting this effective

Язык: Английский

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