Veterinary Microbiology, Год журнала: 2007, Номер 122(3-4), С. 384 - 386
Опубликована: Март 28, 2007
Язык: Английский
Clinical Microbiology Reviews, Год журнала: 2010, Номер 23(3), С. 616 - 687
Опубликована: Июль 1, 2010
SUMMARY Staphylococcus aureus is an important cause of skin and soft-tissue infections (SSTIs), endovascular infections, pneumonia, septic arthritis, endocarditis, osteomyelitis, foreign-body sepsis. Methicillin-resistant S. (MRSA) isolates were once confined largely to hospitals, other health care environments, patients frequenting these facilities. Since the mid-1990s, however, there has been explosion in number MRSA reported populations lacking risk factors for exposure system. This increase incidence infection associated with recognition new clones known as community-associated (CA-MRSA). CA-MRSA strains differ from older, care-associated strains; they infect a different group patients, clinical syndromes, antimicrobial susceptibility patterns, spread rapidly among healthy people community, frequently environments well. review details what about epidemiology spectrum infectious syndromes them that ranges commensal state severe, overwhelming infection. It also addresses therapy strategies their prevention.
Язык: Английский
Процитировано
1816
PLoS ONE, Год журнала: 2011, Номер 6(4), С. e17936 - e17936
Опубликована: Апрель 6, 2011
In recent years, methicillin-resistant Staphylococcus aureus (MRSA) have become a truly global challenge. addition to the long-known healthcare-associated clones, novel strains also emerged outside of hospital settings, in community as well livestock. The emergence and spread virulent clones expressing Panton-Valentine leukocidin (PVL) is an additional cause for concern. order provide overview pandemic, epidemic sporadic strains, more than 3,000 clinical veterinary isolates MRSA mainly from Germany, United Kingdom, Ireland, France, Malta, Abu Dhabi, Hong Kong, Australia, Trinidad & Tobago some reference States been genotyped by DNA microarray analysis. This technique allowed assignment 34 distinct lineages which can be clearly defined based on non-mobile genes. results were accordance with data multilocus sequence typing. More 100 different distinguished affiliation these lineages, SCCmec type presence or absence PVL. These are described here regard clinically relevant antimicrobial resistance- virulence-associated markers, but relation epidemiology geographic distribution. findings study show high level biodiversity among MRSA, especially harbouring IV V elements. indicate rate genetic recombination involving SCC elements, bacteriophages other mobile elements large-scale chromosomal replacements.
Язык: Английский
Процитировано
903
Veterinary Microbiology, Год журнала: 2009, Номер 140(3-4), С. 418 - 429
Опубликована: Фев. 11, 2009
Язык: Английский
Процитировано
615
Antimicrobial Agents and Chemotherapy, Год журнала: 2011, Номер 55(8), С. 3765 - 3773
Опубликована: Июнь 3, 2011
Methicillin resistance in staphylococci is mediated by penicillin binding protein 2a (PBP 2a), encoded mecA on mobile staphylococcal cassette chromosome mec (SCCmec) elements. In this study, two clonal complex 130 (CC130) methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients Irish hospitals were identified that phenotypically PBP positive but lacked conventional PCR and DNA microarray screening. The as methicillin-susceptible S. using the GeneXpert real-time assay. Whole-genome sequencing of one isolate (M10/0061) revealed a 30-kb SCCmec element encoding class E with highly divergent blaZ-mecA-mecR1-mecI, type 8 recombinase (ccr) consisting ccrA1-ccrB3, an arsenic operon, flanking direct repeats (DRs). was almost identical to XI (SCCmec XI) Sanger Institute sequence 425 bovine MRSA strain LGA251 listed website International Working Group Classification Staphylococcal Cassette Chromosome Elements. open reading frames (ORFs) within M10/0061 exhibited 21 93% amino acid identity ORFs GenBank. A third DR ca. 3 kb downstream XI, indicating presence possible SCC remnant. also second CC130 sequencing. may be animal origin previously reported strains predominantly sources. nature relative other elements indicates it have originated another taxon.
Язык: Английский
Процитировано
375
International Journal of Medical Microbiology, Год журнала: 2009, Номер 300(2-3), С. 109 - 117
Опубликована: Дек. 17, 2009
Язык: Английский
Процитировано
291
Trends in Microbiology, Год журнала: 2012, Номер 20(4), С. 192 - 198
Опубликована: Март 2, 2012
Язык: Английский
Процитировано
287
The Veterinary Journal, Год журнала: 2007, Номер 175(1), С. 27 - 36
Опубликована: Янв. 10, 2007
Язык: Английский
Процитировано
277
ILAR Journal, Год журнала: 2010, Номер 51(3), С. 233 - 244
Опубликована: Янв. 1, 2010
Methicillin-resistant Staphylococcus aureus (MRSA) is a critically important human pathogen that also an emerging concern in veterinary medicine and animal agriculture. It present wide range of species, including dogs, cats, rabbits, horses, cattle, pigs, poultry, exotic both as cause infection healthy carriers. Identification MRSA various species food has led to concerns about the roles animals, pets livestock, epidemiology colonization humans. There evidence role animals infections some countries possible source infection. Some groups individuals who work closely with such veterinarians, have high rates. This article includes discussions medicine, food, well its interspecies transmission, colonization, infection, strains, affected populations. However, clear answers are lacking many these areas limited studies may lead premature conclusions. certain circumstances—but humans serve sources animals. Changes one be reflected changes other species. The true scope impact on health still only superficially understood, but it potentially public requires great deal more study enhance understanding effective response.
Язык: Английский
Процитировано
232
Veterinary Microbiology, Год журнала: 2007, Номер 126(4), С. 383 - 389
Опубликована: Июль 26, 2007
Язык: Английский
Процитировано
227
Emerging infectious diseases, Год журнала: 2007, Номер 13(11), С. 1633 - 1639
Опубликована: Ноя. 1, 2007
Resistance to antimicrobial agents is an emerging problem worldwide. Awareness of the undesirable consequences its widespread occurrence has led initiation agent resistance monitoring programs in several countries. In 1995, Denmark was first country establish a systematic and continuous program drug consumption animals, food, humans, Danish Integrated Antimicrobial Monitoring Research Program (DANMAP). range research activities related DANMAP have contributed restrictions or bans use food animals other European Union
Язык: Английский
Процитировано
219