The Burden of Antimicrobial Resistance in Zambia, a Sub-Saharan African Country: A One Health Review of the Current Situation, Risk Factors, and Solutions
Pharmacology & Pharmacy,
Год журнала:
2024,
Номер
15(12), С. 403 - 465
Опубликована: Янв. 1, 2024
Язык: Английский
Point Prevalence Survey of Antibiotic Use in Level 1 hospitals in Zambia: Future Prospects for Antimicrobial Stewardship Programs
Infection and Drug Resistance,
Год журнала:
2025,
Номер
Volume 18, С. 887 - 902
Опубликована: Фев. 1, 2025
The
inappropriate
prescribing
and
use
of
antibiotics
have
contributed
to
the
emergence
spread
antimicrobial
resistance
(AMR).
In
Zambia,
there
is
a
paucity
information
on
patterns
among
hospitalized
patients
in
level
1
hospitals.
This
study
investigated
antibiotic
five
hospitals
Lusaka,
Zambia.
cross-sectional
utilized
World
Health
Organization
(WHO)
Point
Prevalence
Survey
(PPS)
methodology
in-patients
admitted
before
08:00
a.m.
survey
day
August
2024.
Data
were
analysed
using
IBM
SPSS
version
23.0.
prevalence
inpatients
was
59.0%,
with
ceftriaxone
being
most
prescribed.
Antibiotics
prescribed
mainly
for
paediatrics
male
inpatients.
found
that
53.0%
from
Access
group
while
38.2%
Watch
Access,
Watch,
Reserve
(AWaRe)
classification.
Adherence
national
treatment
guidelines
36.0%,
empirically
without
evidence
culture
sensitivity
tests.
high
low
adherence
findings
this
demonstrate
need
establish
strengthen
stewardship
programs
laboratory
capacity
aid
clinicians
diagnosing,
treating,
managing
across
Язык: Английский
A Regional Approach to Strengthening the Implementation of Sustainable Antimicrobial Stewardship Programs in Five Countries in East, Central, and Southern Africa
Antibiotics,
Год журнала:
2025,
Номер
14(3), С. 266 - 266
Опубликована: Март 5, 2025
Background:
Antimicrobial
stewardship
(AMS)
programs
optimize
the
use
of
antimicrobials
and
reduce
antimicrobial
resistance
(AMR).
This
study
evaluated
implementation
AMS
in
Africa
using
a
harmonized
regional
approach.
Methods:
was
an
exploratory
cross-sectional
across
five
countries
involving
32
hospitals
adapted
Periodic
National
Hospitals
Assessment
Tool
from
World
Health
Organization
(WHO)
policy
guidance
on
integrated
activities
human
health.
Results:
found
baseline
scores
for
core
elements
ranging
34%
to
79%
at
which
improved
58%
92%
endline.
At
baseline,
Drugs
Therapeutics
Committee
(DTC)
functionality
updating
facility-specific
medicines
medical
devices
ranged
100%,
this
79
100%
Classifying
antibiotics
by
WHO
AWaRe,
classification
33%
83%
64%
Leadership
commitment
were
47%
66%
Education
training
42%
63%
endline,
respectively.
Reporting
feedback
Conclusions:
Our
showed
that
understanding
context
standardizing
approaches
enhanced
cross-country
learning
implementation.
Although
challenges
Low-
Middle-Income
Countries
(LMICs)
are
similar,
they
vary
country
can
be
addressed
strengthening
regulatory
frameworks
surveillance
systems.
Язык: Английский
Antimicrobial Stewardship Impact on Antibiotic Use in Three Tertiary Hospitals in Zambia: A Comparative Point Prevalence Survey
Antibiotics,
Год журнала:
2025,
Номер
14(3), С. 284 - 284
Опубликована: Март 10, 2025
Introduction:
Antimicrobial
stewardship
(AMS)
can
improve
the
rational
use
of
antibiotics
in
hospitals.
This
study
assessed
impact
a
multifaceted
AMS
intervention
on
antibiotic
and
prescribing
patterns
at
three
tertiary
hospitals
Zambia.
Methods:
Point
Prevalence
Surveys
(PPS)
were
conducted
August
2022
October
2023.
It
was
part
3-year
demonstration
project
that
aimed
to
optimize
treating
urinary
tract
infections
(UTIs)
bloodstream
(BSIs)
various
health
sector
settings
Up
170
medical
records
265
2023
included
assessment.
Results:
Overall,
prevalence
this
PPS
75%.
Eighty-one
percent
(81%)
71%
patients
least
one
2023,
respectively,
indicating
decrease
10%.
Similarly,
ceftriaxone,
most
prescribed
antibiotic,
declined
from
an
average
48%
38%
Adherence
Standard
Treatment
Guidelines
(STGs)
slightly
increased
42%
45%
Additionally,
reduced
1.38
1.21.
Conclusions:
had
early
positive
adherence
Guidelines.
Язык: Английский
Antibiotic use at the Centre Hospitalier Universitaire de Zone d'Abomey Calavi/Sô-Ava (CHUZ/AS) in Benin: a point prevalence survey
JAC-Antimicrobial Resistance,
Год журнала:
2024,
Номер
7(1)
Опубликована: Дек. 26, 2024
Abstract
Background
Antimicrobial
stewardship
promotes
the
appropriate
use
of
antibiotics
to
prevent
emergence
and
spread
antimicrobial
resistance.
This
study
evaluated
using
a
point
prevalence
survey
at
Centre
Hospitalier
Universitaire
de
Zone
d'Abomey
Calavi/Sô-Ava
(CHUZ/AS)
in
Benin.
Methods
cross-sectional
utilized
WHO
methodology
for
monitoring
antibiotic
among
inpatients
hospitals.
The
was
conducted
from
11
January
2022
19
hospitalized
patients
before
8:00
a.m.
on
day
survey.
Results
Of
111
inpatient
medical
files
reviewed,
82.9%.
number
received
per
patient
ranged
1
5,
with
mean
2.45
±
1.11
median
2.
most
commonly
prescribed
class
beta-lactams
(46.7%),
aminoglycosides
(20.6%)
nitroimidazoles
(19.7%).
According
AWaRe
classification,
30.4%
Access
group
44%
combination
Watch
antibiotics;
treatment
empiric
94.5%
encounters.
Only
22.7%
were
treated
based
microbiological
examination/culture
sensitivity
testing.
Conclusions
found
high
CHUZ/AS
Tertiary
Care
Hospital
ampicillin,
metronidazole
ceftriaxone.
Consequently,
low
culture
testing
guide
treatment,
particularly
paediatric
surgical
population,
preference
broad-spectrum
suggests
that
is
not
optimal.
Therefore,
programmes,
policies
guidelines
must
be
instigated
strengthened
address
these
gaps
promote
rational
antibiotics.
Язык: Английский