Antibiotic use at the Centre Hospitalier Universitaire de Zone d'Abomey Calavi/Sô-Ava (CHUZ/AS) in Benin: a point prevalence survey DOI Creative Commons

Morelle Sèssiwèdé Gnimavo,

Bawa Boya, Steward Mudenda

et al.

JAC-Antimicrobial Resistance, Journal Year: 2024, Volume and Issue: 7(1)

Published: Dec. 26, 2024

Abstract Background Antimicrobial stewardship promotes the appropriate use of antibiotics to prevent emergence and spread antimicrobial resistance. This study evaluated using a point prevalence survey at Centre Hospitalier Universitaire de Zone d'Abomey Calavi/Sô-Ava (CHUZ/AS) in Benin. Methods cross-sectional utilized WHO methodology for monitoring antibiotic among inpatients hospitals. The was conducted from 11 January 2022 19 hospitalized patients before 8:00 a.m. on day survey. Results Of 111 inpatient medical files reviewed, 82.9%. number received per patient ranged 1 5, with mean 2.45 ± 1.11 median 2. most commonly prescribed class beta-lactams (46.7%), aminoglycosides (20.6%) nitroimidazoles (19.7%). According AWaRe classification, 30.4% Access group 44% combination Watch antibiotics; treatment empiric 94.5% encounters. Only 22.7% were treated based microbiological examination/culture sensitivity testing. Conclusions found high CHUZ/AS Tertiary Care Hospital ampicillin, metronidazole ceftriaxone. Consequently, low culture testing guide treatment, particularly paediatric surgical population, preference broad-spectrum suggests that is not optimal. Therefore, programmes, policies guidelines must be instigated strengthened address these gaps promote rational antibiotics.

Language: Английский

The Burden of Antimicrobial Resistance in Zambia, a Sub-Saharan African Country: A One Health Review of the Current Situation, Risk Factors, and Solutions DOI Open Access
Steward Mudenda, Webrod Mufwambi,

Shafiq Mohamed

et al.

Pharmacology &amp Pharmacy, Journal Year: 2024, Volume and Issue: 15(12), P. 403 - 465

Published: Jan. 1, 2024

Language: Английский

Citations

7
Point Prevalence Survey of Antibiotic Use in Level 1 hospitals in Zambia: Future Prospects for Antimicrobial Stewardship Programs DOI Creative Commons
Steward Mudenda, Adriano Focus Lubanga, Shazia Jamshed

et al.

Infection and Drug Resistance, Journal Year: 2025, Volume and Issue: Volume 18, P. 887 - 902

Published: Feb. 1, 2025

The inappropriate prescribing and use of antibiotics have contributed to the emergence spread antimicrobial resistance (AMR). In Zambia, there is a paucity information on patterns among hospitalized patients in level 1 hospitals. This study investigated antibiotic five hospitals Lusaka, Zambia. cross-sectional utilized World Health Organization (WHO) Point Prevalence Survey (PPS) methodology in-patients admitted before 08:00 a.m. survey day August 2024. Data were analysed using IBM SPSS version 23.0. prevalence inpatients was 59.0%, with ceftriaxone being most prescribed. Antibiotics prescribed mainly for paediatrics male inpatients. found that 53.0% from Access group while 38.2% Watch Access, Watch, Reserve (AWaRe) classification. Adherence national treatment guidelines 36.0%, empirically without evidence culture sensitivity tests. high low adherence findings this demonstrate need establish strengthen stewardship programs laboratory capacity aid clinicians diagnosing, treating, managing across

Language: Английский

Citations

1
Current status and future direction of antimicrobial stewardship programs and antibiotic prescribing in primary care hospitals in Zambia DOI Creative Commons

Faustina Makiko,

Aubrey Chichonyi Kalungia, Martin Kampamba

et al.

JAC-Antimicrobial Resistance, Journal Year: 2025, Volume and Issue: 7(3)

Published: April 29, 2025

Antimicrobial Stewardship Programs (ASPs) intended to optimize antibiotic use will be more effective if informed by the current status and patterns of utilisation. In Zambia's primary healthcare (PHC) settings, data on ASPs utilisation were inadequate guide improvements. As a first step, this study assessed prescribing ASP core elements among PHC first-level hospitals (FLHs) in Zambia. A point prevalence survey was conducted at five FLHs Lusaka using Global-PPS® protocol. Hospital evaluated included hospital leadership commitment, accountability, pharmacy expertise, action, tracking, reporting, education. Antibiotic 79.8% (146/183). total 220 prescription encounters recorded inpatients, with ceftriaxone (J01DD04, Watch) being most (50.0%) prescribed. Over 90.0% (202) prescriptions targeted suspected community-acquired infections, but only 36.8% (81) compliant national treatment guidelines. element implementation 36.0% (16.2/45), two achieving over 50.0%. The deficient reporting. providing sub-optimal, high rates, frequent broad-spectrum Watch group antibiotics, low compliance key ways forward, require strengthening adapting WHO AWaRe recommendations improving actions, reporting improve stewardship practice reduce AMR.

Language: Английский

Citations

1
A Regional Approach to Strengthening the Implementation of Sustainable Antimicrobial Stewardship Programs in Five Countries in East, Central, and Southern Africa DOI Creative Commons
Evelyn Wesangula, Joseph Yamweka Chizimu, Siana Mapunjo

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(3), P. 266 - 266

Published: March 5, 2025

Background: Antimicrobial stewardship (AMS) programs optimize the use of antimicrobials and reduce antimicrobial resistance (AMR). This study evaluated implementation AMS in Africa using a harmonized regional approach. Methods: was an exploratory cross-sectional across five countries involving 32 hospitals adapted Periodic National Hospitals Assessment Tool from World Health Organization (WHO) policy guidance on integrated activities human health. Results: found baseline scores for core elements ranging 34% to 79% at which improved 58% 92% endline. At baseline, Drugs Therapeutics Committee (DTC) functionality updating facility-specific medicines medical devices ranged 100%, this 79 100% Classifying antibiotics by WHO AWaRe, classification 33% 83% 64% Leadership commitment were 47% 66% Education training 42% 63% endline, respectively. Reporting feedback Conclusions: Our showed that understanding context standardizing approaches enhanced cross-country learning implementation. Although challenges Low- Middle-Income Countries (LMICs) are similar, they vary country can be addressed strengthening regulatory frameworks surveillance systems.

Language: Английский

Citations

0
Antimicrobial Stewardship Impact on Antibiotic Use in Three Tertiary Hospitals in Zambia: A Comparative Point Prevalence Survey DOI Creative Commons
Steward Mudenda,

Kenneth Kapolowe,

Uchizi Chirwa

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(3), P. 284 - 284

Published: March 10, 2025

Introduction: Antimicrobial stewardship (AMS) can improve the rational use of antibiotics in hospitals. This study assessed impact a multifaceted AMS intervention on antibiotic and prescribing patterns at three tertiary hospitals Zambia. Methods: Point Prevalence Surveys (PPS) were conducted August 2022 October 2023. It was part 3-year demonstration project that aimed to optimize treating urinary tract infections (UTIs) bloodstream (BSIs) various health sector settings Up 170 medical records 265 2023 included assessment. Results: Overall, prevalence this PPS 75%. Eighty-one percent (81%) 71% patients least one 2023, respectively, indicating decrease 10%. Similarly, ceftriaxone, most prescribed antibiotic, declined from an average 48% 38% Adherence Standard Treatment Guidelines (STGs) slightly increased 42% 45% Additionally, reduced 1.38 1.21. Conclusions: had early positive adherence Guidelines.

Language: Английский

Citations

0
Tools and challenges in the use of routine clinical data for antimicrobial resistance surveillance DOI Creative Commons
Kathryn E. Holt, Megan E. Carey, Clare Chandler

et al.

npj Antimicrobials and Resistance, Journal Year: 2025, Volume and Issue: 3(1)

Published: May 9, 2025

Language: Английский

Citations

0
Antibiotic use at the Centre Hospitalier Universitaire de Zone d'Abomey Calavi/Sô-Ava (CHUZ/AS) in Benin: a point prevalence survey DOI Creative Commons

Morelle Sèssiwèdé Gnimavo,

Bawa Boya, Steward Mudenda

et al.

JAC-Antimicrobial Resistance, Journal Year: 2024, Volume and Issue: 7(1)

Published: Dec. 26, 2024

Abstract Background Antimicrobial stewardship promotes the appropriate use of antibiotics to prevent emergence and spread antimicrobial resistance. This study evaluated using a point prevalence survey at Centre Hospitalier Universitaire de Zone d'Abomey Calavi/Sô-Ava (CHUZ/AS) in Benin. Methods cross-sectional utilized WHO methodology for monitoring antibiotic among inpatients hospitals. The was conducted from 11 January 2022 19 hospitalized patients before 8:00 a.m. on day survey. Results Of 111 inpatient medical files reviewed, 82.9%. number received per patient ranged 1 5, with mean 2.45 ± 1.11 median 2. most commonly prescribed class beta-lactams (46.7%), aminoglycosides (20.6%) nitroimidazoles (19.7%). According AWaRe classification, 30.4% Access group 44% combination Watch antibiotics; treatment empiric 94.5% encounters. Only 22.7% were treated based microbiological examination/culture sensitivity testing. Conclusions found high CHUZ/AS Tertiary Care Hospital ampicillin, metronidazole ceftriaxone. Consequently, low culture testing guide treatment, particularly paediatric surgical population, preference broad-spectrum suggests that is not optimal. Therefore, programmes, policies guidelines must be instigated strengthened address these gaps promote rational antibiotics.

Language: Английский

Citations

2