The Burden of Antimicrobial Resistance in Zambia, a Sub-Saharan African Country: A One Health Review of the Current Situation, Risk Factors, and Solutions
Pharmacology & Pharmacy,
Journal Year:
2024,
Volume and Issue:
15(12), P. 403 - 465
Published: Jan. 1, 2024
Language: Английский
Point Prevalence Survey of Antibiotic Use in Level 1 hospitals in Zambia: Future Prospects for Antimicrobial Stewardship Programs
Infection and Drug Resistance,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 887 - 902
Published: Feb. 1, 2025
The
inappropriate
prescribing
and
use
of
antibiotics
have
contributed
to
the
emergence
spread
antimicrobial
resistance
(AMR).
In
Zambia,
there
is
a
paucity
information
on
patterns
among
hospitalized
patients
in
level
1
hospitals.
This
study
investigated
antibiotic
five
hospitals
Lusaka,
Zambia.
cross-sectional
utilized
World
Health
Organization
(WHO)
Point
Prevalence
Survey
(PPS)
methodology
in-patients
admitted
before
08:00
a.m.
survey
day
August
2024.
Data
were
analysed
using
IBM
SPSS
version
23.0.
prevalence
inpatients
was
59.0%,
with
ceftriaxone
being
most
prescribed.
Antibiotics
prescribed
mainly
for
paediatrics
male
inpatients.
found
that
53.0%
from
Access
group
while
38.2%
Watch
Access,
Watch,
Reserve
(AWaRe)
classification.
Adherence
national
treatment
guidelines
36.0%,
empirically
without
evidence
culture
sensitivity
tests.
high
low
adherence
findings
this
demonstrate
need
establish
strengthen
stewardship
programs
laboratory
capacity
aid
clinicians
diagnosing,
treating,
managing
across
Language: Английский
Current status and future direction of antimicrobial stewardship programs and antibiotic prescribing in primary care hospitals in Zambia
JAC-Antimicrobial Resistance,
Journal Year:
2025,
Volume and Issue:
7(3)
Published: April 29, 2025
Antimicrobial
Stewardship
Programs
(ASPs)
intended
to
optimize
antibiotic
use
will
be
more
effective
if
informed
by
the
current
status
and
patterns
of
utilisation.
In
Zambia's
primary
healthcare
(PHC)
settings,
data
on
ASPs
utilisation
were
inadequate
guide
improvements.
As
a
first
step,
this
study
assessed
prescribing
ASP
core
elements
among
PHC
first-level
hospitals
(FLHs)
in
Zambia.
A
point
prevalence
survey
was
conducted
at
five
FLHs
Lusaka
using
Global-PPS®
protocol.
Hospital
evaluated
included
hospital
leadership
commitment,
accountability,
pharmacy
expertise,
action,
tracking,
reporting,
education.
Antibiotic
79.8%
(146/183).
total
220
prescription
encounters
recorded
inpatients,
with
ceftriaxone
(J01DD04,
Watch)
being
most
(50.0%)
prescribed.
Over
90.0%
(202)
prescriptions
targeted
suspected
community-acquired
infections,
but
only
36.8%
(81)
compliant
national
treatment
guidelines.
element
implementation
36.0%
(16.2/45),
two
achieving
over
50.0%.
The
deficient
reporting.
providing
sub-optimal,
high
rates,
frequent
broad-spectrum
Watch
group
antibiotics,
low
compliance
key
ways
forward,
require
strengthening
adapting
WHO
AWaRe
recommendations
improving
actions,
reporting
improve
stewardship
practice
reduce
AMR.
Language: Английский
A Regional Approach to Strengthening the Implementation of Sustainable Antimicrobial Stewardship Programs in Five Countries in East, Central, and Southern Africa
Antibiotics,
Journal Year:
2025,
Volume and Issue:
14(3), P. 266 - 266
Published: March 5, 2025
Background:
Antimicrobial
stewardship
(AMS)
programs
optimize
the
use
of
antimicrobials
and
reduce
antimicrobial
resistance
(AMR).
This
study
evaluated
implementation
AMS
in
Africa
using
a
harmonized
regional
approach.
Methods:
was
an
exploratory
cross-sectional
across
five
countries
involving
32
hospitals
adapted
Periodic
National
Hospitals
Assessment
Tool
from
World
Health
Organization
(WHO)
policy
guidance
on
integrated
activities
human
health.
Results:
found
baseline
scores
for
core
elements
ranging
34%
to
79%
at
which
improved
58%
92%
endline.
At
baseline,
Drugs
Therapeutics
Committee
(DTC)
functionality
updating
facility-specific
medicines
medical
devices
ranged
100%,
this
79
100%
Classifying
antibiotics
by
WHO
AWaRe,
classification
33%
83%
64%
Leadership
commitment
were
47%
66%
Education
training
42%
63%
endline,
respectively.
Reporting
feedback
Conclusions:
Our
showed
that
understanding
context
standardizing
approaches
enhanced
cross-country
learning
implementation.
Although
challenges
Low-
Middle-Income
Countries
(LMICs)
are
similar,
they
vary
country
can
be
addressed
strengthening
regulatory
frameworks
surveillance
systems.
Language: Английский
Antimicrobial Stewardship Impact on Antibiotic Use in Three Tertiary Hospitals in Zambia: A Comparative Point Prevalence Survey
Steward Mudenda,
No information about this author
Kenneth Kapolowe,
No information about this author
Uchizi Chirwa
No information about this author
et al.
Antibiotics,
Journal Year:
2025,
Volume and Issue:
14(3), P. 284 - 284
Published: March 10, 2025
Introduction:
Antimicrobial
stewardship
(AMS)
can
improve
the
rational
use
of
antibiotics
in
hospitals.
This
study
assessed
impact
a
multifaceted
AMS
intervention
on
antibiotic
and
prescribing
patterns
at
three
tertiary
hospitals
Zambia.
Methods:
Point
Prevalence
Surveys
(PPS)
were
conducted
August
2022
October
2023.
It
was
part
3-year
demonstration
project
that
aimed
to
optimize
treating
urinary
tract
infections
(UTIs)
bloodstream
(BSIs)
various
health
sector
settings
Up
170
medical
records
265
2023
included
assessment.
Results:
Overall,
prevalence
this
PPS
75%.
Eighty-one
percent
(81%)
71%
patients
least
one
2023,
respectively,
indicating
decrease
10%.
Similarly,
ceftriaxone,
most
prescribed
antibiotic,
declined
from
an
average
48%
38%
Adherence
Standard
Treatment
Guidelines
(STGs)
slightly
increased
42%
45%
Additionally,
reduced
1.38
1.21.
Conclusions:
had
early
positive
adherence
Guidelines.
Language: Английский
Tools and challenges in the use of routine clinical data for antimicrobial resistance surveillance
npj Antimicrobials and Resistance,
Journal Year:
2025,
Volume and Issue:
3(1)
Published: May 9, 2025
Language: Английский
Antibiotic use at the Centre Hospitalier Universitaire de Zone d'Abomey Calavi/Sô-Ava (CHUZ/AS) in Benin: a point prevalence survey
Morelle Sèssiwèdé Gnimavo,
No information about this author
Bawa Boya,
No information about this author
Steward Mudenda
No information about this author
et al.
JAC-Antimicrobial Resistance,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: Dec. 26, 2024
Abstract
Background
Antimicrobial
stewardship
promotes
the
appropriate
use
of
antibiotics
to
prevent
emergence
and
spread
antimicrobial
resistance.
This
study
evaluated
using
a
point
prevalence
survey
at
Centre
Hospitalier
Universitaire
de
Zone
d'Abomey
Calavi/Sô-Ava
(CHUZ/AS)
in
Benin.
Methods
cross-sectional
utilized
WHO
methodology
for
monitoring
antibiotic
among
inpatients
hospitals.
The
was
conducted
from
11
January
2022
19
hospitalized
patients
before
8:00
a.m.
on
day
survey.
Results
Of
111
inpatient
medical
files
reviewed,
82.9%.
number
received
per
patient
ranged
1
5,
with
mean
2.45
±
1.11
median
2.
most
commonly
prescribed
class
beta-lactams
(46.7%),
aminoglycosides
(20.6%)
nitroimidazoles
(19.7%).
According
AWaRe
classification,
30.4%
Access
group
44%
combination
Watch
antibiotics;
treatment
empiric
94.5%
encounters.
Only
22.7%
were
treated
based
microbiological
examination/culture
sensitivity
testing.
Conclusions
found
high
CHUZ/AS
Tertiary
Care
Hospital
ampicillin,
metronidazole
ceftriaxone.
Consequently,
low
culture
testing
guide
treatment,
particularly
paediatric
surgical
population,
preference
broad-spectrum
suggests
that
is
not
optimal.
Therefore,
programmes,
policies
guidelines
must
be
instigated
strengthened
address
these
gaps
promote
rational
antibiotics.
Language: Английский