Human Brain Mapping,
Год журнала:
2022,
Номер
43(8), С. 2495 - 2502
Опубликована: Фев. 2, 2022
To
investigate
the
feasibility
of
quantitative
susceptibility
mapping
in
children
with
attention-deficit
hyperactivity
disorder
(ADHD),
53
ADHD
aged
5-16
years
were
prospectively
selected
as
study
group
and
49
healthy
matched
age
gender
control
group.
All
underwent
magnetic
resonance
imaging
conventional
sequence,
3D-T1,
enhanced
T2*-weighted
angiography
(ESWAN)
sequence
scanning.
The
iron
content
brain
regions
was
obtained
through
software
postprocessing,
compared
analyzed
to
find
out
characteristics
ADHD.
frontal
lobe,
globus
pallidus,
caudate
nucleus,
substantia
nigra,
putamen,
hippocampus
lower
than
that
(p
<
.05).
There
no
significant
difference
left
right
>
volume
lobe
Iron
areas
such
hippocampus,
putamen
could
distinguish
(Area
under
curve
[AUC]
0.5,
p
Quantitative
showed
decreased
some
Abstract
Background
This
meta-analysis
aimed
to
explore
the
most
robust
findings
across
numerous
existing
resting-state
functional
imaging
and
voxel-based
morphometry
(VBM)
studies
on
structural
brain
alterations
in
individuals
with
autism
spectrum
disorder
(ASD).
Methods
A
whole-brain
voxel-wise
was
conducted
compare
differences
intrinsic
activity
gray
matter
volume
(GMV)
between
ASD
typically
developing
(TDs)
using
Seed-based
d
Mapping
software.
Results
total
of
23
(786
ASD,
710
TDs)
52
VBM
(1728
1747
were
included.
Compared
TDs,
displayed
decreases
left
insula
(extending
superior
temporal
gyrus
[STG]),
bilateral
anterior
cingulate
cortex/medial
prefrontal
cortex
(ACC/mPFC),
angular
right
inferior
gyrus,
as
well
increases
supplementary
motor
area
precuneus.
For
meta-analysis,
decreased
GMV
ACC/mPFC
cerebellum,
increased
middle
STG),
olfactory
cortex,
precentral
gyrus.
Further,
after
overlapping
differences.
Conclusions
The
present
multimodal
demonstrated
that
exhibited
similar
both
function
structure
ACC/mPFC,
or
default
mode
network
(DMN),
primary
sensory
regions.
These
contribute
further
understanding
pathophysiology
ASD.
The Cerebellum,
Год журнала:
2022,
Номер
22(5), С. 852 - 864
Опубликована: Авг. 23, 2022
Abstract
The
cerebellum’s
role
in
affective
processing
is
increasingly
recognized
the
literature,
but
remains
poorly
understood,
despite
abundant
clinical
evidence
for
disruptions
following
cerebellar
damage.
To
improve
characterization
of
emotion
and
investigate
how
attention
allocation
impacts
this
processing,
we
conducted
a
meta-analysis
on
task
activation
foci
using
GingerALE
software.
Eighty
human
neuroimaging
studies
including
2761
participants
identified
through
Web
Science
ProQuest
databases
were
analyzed
collectively
then
divided
into
two
categories
based
focus
during
task:
explicit
or
implicit
processing.
results
examining
tasks
clusters
within
posterior
hemispheres
(bilateral
lobule
VI/Crus
I/II),
vermis,
left
V/VI
that
likely
to
be
activated
across
studies,
while
bilateral
lobules
I/II,
right
Crus
II/lobule
VIII,
anterior
VI,
I-IV/V.
A
direct
comparison
between
these
revealed
five
overlapping
I/Crus
II
V/VI/Crus
I
cerebellum
common
both
contrasts.
There
also
three
significantly
more
compared
(right
VI/vermis),
one
cluster
than
(left
VI).
These
findings
support
previous
indicating
activates
lateral
hemispheric
vermis
cerebellum.
distinct
regions
by
with
demonstrates
supportive
structure
recognizing,
appraising,
reacting
emotional
stimuli.
Development and Psychopathology,
Год журнала:
2025,
Номер
unknown, С. 1 - 15
Опубликована: Март 18, 2025
Abstract
Childhood
obsessive-compulsive
disorder
(OCD)
stems
from
a
bunch
of
restricted
and
repetitive
behaviors,
which
are
part
normal
behavioral
repertoire
up
to
the
age
7.
The
persistence
compulsive-like
behaviors
after
that
is
often
associated
with
unique
comorbidity
patterns,
age-at-onset
dependent
reflect
different
developmental
stages.
In
particular,
OCD
synchronically
co-occurs
broad
constellation
neurodevelopmental
disorders,
whereas
diachronically
it
related
an
increased
risk
major
adult
psychoses.
Moreover,
trait-like
sensory
phenomena,
suggesting
common
disrupted
sensorimotor
grounding.
present
study
aimed
at
exploring
hypothesis
this
specific
temporal
profile
may
be
due
heterochronic
mechanism
delay
in
attenuation
ontogenetically
early
patterns.
shift
highly
evolutionarily
conserved
phenotypes
might
regulated
by
epigenetic
changes
induced
conditions
unbalance.
This
evolutionary
model
allows
capturing
childhood
light
ultimate
causes
ritual
behavior
throughout
phylogeny,
namely
its
“homeostatic”
function
over
unpredictability.
have
important
clinical
implications,
as
symptoms
could
represent
putative
biomarkers
divergent
trajectories,
pathoplastic
effect
on
course
outcome.
