Effect of oral melatonin and wearing earplugs and eye masks on nocturnal sleep in healthy subjects in a simulated intensive care unit environment: which might be a more promising strategy for ICU sleep deprivation? DOI Creative Commons
Hua-Wei Huang,

Bo-Lu Zheng,

Li Jiang

et al.

Critical Care, Journal Year: 2015, Volume and Issue: 19(1)

Published: March 13, 2015

Sleep deprivation is common in critically ill patients the intensive care unit (ICU). Noise and light ICU reduction plasma melatonin play essential roles. The aim of this study was to determine effect simulated noise on nocturnal sleep quality, compare effectiveness earplugs eye masks quality these conditions healthy subjects.This conducted two parts. In part one, 40 subjects slept under baseline night (NL) by a cross-over design. two, were randomly assigned four groups: NL, NL plus placebo (NLP), use (NLEE) (NLM). 1 mg oral or administered at 21:00 consecutive days NLM NLP. Earplugs made available NLEE. objective measured polysomnography. Serum analyzed for levels. Subjects rated their perceived anxiety levels.Subjects had shorter total time (TST) rapid movement (REM) sleep, longer onset latency, more awakening, poorer subjective higher level lower serum (P <0.05). NLEE less awakenings latency TST REM Compared with NLEE, fewer = 0.004). Both improved 0.000), showed better than 0.01). night, levels every point, average maximal concentration group significantly greater other groups <0.001).Compared masks, improves exposed light.Chinese Clinical Trial Registry ChiCTR-IPR-14005458 . Registered 10 November 2014.

Language: Английский

Melatonin: Buffering the Immune System DOI Open Access
Antonio Carrillo‐Vico, Patricia Judith Lardone, Nuria Álvarez‐Sánchez

et al.

International Journal of Molecular Sciences, Journal Year: 2013, Volume and Issue: 14(4), P. 8638 - 8683

Published: April 22, 2013

Melatonin modulates a wide range of physiological functions with pleiotropic effects on the immune system. Despite large number reports implicating melatonin as an immunomodulatory compound, it still remains unclear how regulates immunity. While some authors argue that is immunostimulant, many studies have also described anti-inflammatory properties. The data reviewed in this paper support idea buffer, acting stimulant under basal or immunosuppressive conditions compound presence exacerbated responses, such acute inflammation. clinical relevance multiple different conditions, infection, autoimmunity, vaccination and immunosenescence, reviewed.

Language: Английский

Citations

667
A Review of the Multiple Actions of Melatonin on the Immune System DOI
Antonio Carrillo‐Vico, Juan M. Guerrero, Patricia Judith Lardone

et al.

Endocrine, Journal Year: 2005, Volume and Issue: 27(2), P. 189 - 200

Published: Jan. 1, 2005

Language: Английский

Citations

661
Neuropathogenesis of Delirium: Review of Current Etiologic Theories and Common Pathways DOI
José R. Maldonado

American Journal of Geriatric Psychiatry, Journal Year: 2013, Volume and Issue: 21(12), P. 1190 - 1222

Published: Nov. 8, 2013

Language: Английский

Citations

618
Dysregulation of Inflammatory Responses by Chronic Circadian Disruption DOI Open Access
Oscar Castañón‐Cervantes,

Mingwei Wu,

J. Christopher Ehlen

et al.

The Journal of Immunology, Journal Year: 2010, Volume and Issue: 185(10), P. 5796 - 5805

Published: Oct. 14, 2010

Circadian rhythms modulate nearly every mammalian physiological process. Chronic disruption of circadian timing in shift work or during chronic jet lag animal models leads to a higher risk several pathologies. Many these conditions both workers and experimental share the common factor inflammation. In this study, we show that experimentally induced altered innate immune responses. Endotoxemic shock by LPS was magnified, leading hypothermia death after four consecutive weekly 6-h phase advances light/dark schedule, with 89% mortality compared 21% unshifted control mice. This may be due heightened release proinflammatory cytokines response treatment shifted animals. Isolated peritoneal macrophages harvested from mice exhibited similarly vitro, indicating cells are target for lag. Sleep deprivation stress known alter function potential mediators effects describe. However, polysomnographic recording exposed shifting schedule revealed no sleep loss, measures were not contrast, observed abolished expression clock genes central clock, liver, thymus, We conclude disruption, but loss stress, associated lag-related dysregulation system. Such changes might mechanism myriad negative health work.

Language: Английский

Citations

497
Delirium pathophysiology: An updated hypothesis of the etiology of acute brain failure DOI Open Access
José R. Maldonado

International Journal of Geriatric Psychiatry, Journal Year: 2017, Volume and Issue: 33(11), P. 1428 - 1457

Published: Dec. 26, 2017

Delirium is the most common neuropsychiatric syndrome encountered by clinicians dealing with older adults and medically ill best characterized 5 core domains: cognitive deficits, attentional circadian rhythm dysregulation, emotional alteration in psychomotor functioning.An extensive literature review consolidation of published data into a novel interpretation known pathophysiological causes delirium.Available suggest that numerous pathological factors may serve as precipitants for delirium, each having differential effects depending on patient-specific patient physiological characteristics (substrate). On basis an search, newly proposed theory, systems integration failure hypothesis, was developed to bring together salient previously described theories, describing various contributions from complex web pathways-highlighting areas intersection commonalities explaining how variable contribution these lead development behavioral dysfunctions characteristic delirium. The specific manifestations delirium picture result combination neurotransmitter function availability, variability processing sensory information, motor responses both external internal cues, degree breakdown neuronal network connectivity, hence term acute brain failure.The hypothesis attempts explain pathophysiologic theories interact other, causing clinically observed phenotypes. A better understanding underlying pathophysiology eventually assist designing prevention management approaches.

Language: Английский

Citations

471
Sleep Deprivation in Critical Illness DOI
Biren B. Kamdar, Dale M. Needham,

Nancy A. Collop

et al.

Journal of Intensive Care Medicine, Journal Year: 2011, Volume and Issue: 27(2), P. 97 - 111

Published: Jan. 10, 2011

Critically ill patients frequently experience poor sleep, characterized by frequent disruptions, loss of circadian rhythms, and a paucity time spent in restorative sleep stages. Factors that are associated with disruption the intensive care unit (ICU) include patient-ventilator dysynchrony, medications, patient interactions, environmental noise light. As field critical increasingly focuses on patients’ physical psychological outcomes following illness, understanding potential contribution ICU-related recovery is an important area investigation. This review article summarizes literature regarding architecture measurement critically ill, causes ICU fragmentation, implications from illness. With this background information, strategies to optimize also discussed.

Language: Английский

Citations

403
Melatonin receptors in humans: biological role and clinical relevance DOI
Cem Ekmekçioğlu

Biomedicine & Pharmacotherapy, Journal Year: 2006, Volume and Issue: 60(3), P. 97 - 108

Published: Feb. 21, 2006

Language: Английский

Citations

348
Stress and circulating cell-free mitochondrial DNA: A systematic review of human studies, physiological considerations, and technical recommendations DOI Creative Commons
Caroline Trumpff, Jeremy Michelson, Claúdia Jacques Lagranha

et al.

Mitochondrion, Journal Year: 2021, Volume and Issue: 59, P. 225 - 245

Published: April 9, 2021

Cell-free mitochondrial DNA (cf-mtDNA) is a marker of inflammatory disease and predictor mortality, but little known about cf-mtDNA in relation to psychobiology. A systematic review the literature reveals that blood varies response common real-world stressors including psychopathology, acute psychological stress, exercise. Moreover, inducible within minutes exhibits high intra-individual day-to-day variation, highlighting dynamic regulation levels. We discuss current knowledge on mechanisms release, its forms transport ("cell-free" does not mean "membrane-free"), potential physiological functions, putative cellular neuroendocrine triggers, factors may contribute removal from circulation. vitro, pre-clinical, clinical studies shows conflicting results around dogma are pro-inflammatory, opening possibility other cell-to-cell transfer whole mitochondria. Finally, enhance reproducibility biological interpretation human research, we propose guidelines for collection, isolation, quantification, reporting standards, which can promote concerted advances by community. Defining mechanistic basis signaling an opportunity elucidate role mitochondria brain-body interactions psychopathology.

Language: Английский

Citations

127
Sleep in the intensive care unit DOI Open Access
Sairam Parthasarathy,

Martin J. Tobin

Intensive Care Medicine, Journal Year: 2004, Volume and Issue: 30(2), P. 197 - 206

Published: Feb. 1, 2004

Language: Английский

Citations

343
Sleep and delirium in ICU patients: a review of mechanisms and manifestations DOI
Milagros I. Figueroa-Ramos, Carmen Mabel Arroyo-Novoa, Kathryn A. Lee

et al.

Intensive Care Medicine, Journal Year: 2009, Volume and Issue: 35(5), P. 781 - 795

Published: Jan. 22, 2009

Language: Английский

Citations

250