SARS-CoV-2 positivity in offspring and timing of mother-to-child transmission: living systematic review and meta-analysis

BMJ, Год журнала: 2022, Номер unknown, С. e067696 - e067696

Опубликована: Март 16, 2022

To assess the rates of SARS-CoV-2 positivity in babies born to mothers with infection, timing mother-to-child transmission and perinatal outcomes, factors associated status offspring.

Язык: Английский

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Pathogenesis of viral infections during pregnancy

Clinical Microbiology Reviews, Год журнала: 2024, Номер 37(2)

Опубликована: Фев. 29, 2024

SUMMARY Viral infections during pregnancy are associated with significant adverse perinatal and fetal outcomes. Pregnancy is a unique immunologic physiologic state, which can influence control of virus replication, severity disease, vertical transmission. The placenta the organ maternal-fetal interface provides defense against microbial infection while supporting semi-allogeneic fetus via tolerogenic immune responses. Some viruses, such as cytomegalovirus, Zika virus, rubella breach these defenses, directly infecting having long-lasting consequences. Even without direct placental infection, other including respiratory viruses like influenza severe acute syndrome coronavirus 2, still cause damage inflammation. Concentrations progesterone estrogens rise contribute to immunological adaptations, placentation, development play pivotal role in creating environment at interface. Animal models, mice, nonhuman primates, rabbits, guinea pigs, instrumental for mechanistic insights into pathogenesis viral identification targetable treatments improve health outcomes pregnant individuals offspring.

Язык: Английский

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Rate of vertical transmission of coronavirus disease 2019 and effect of maternal vaccination: A prospective cohort study

Pediatrics International, Год журнала: 2025, Номер 67(1)

Опубликована: Янв. 1, 2025

Abstract Background We aimed to reveal the transmission rate of coronavirus disease 2019 (COVID‐19) and clinical features congenital neonatal COVID‐19 disclose efficacy maternally transferred antibodies by maternal vaccination against severe acute respiratory syndrome 2 (SARS‐CoV‐2). Methods This multicenter, prospective observational study included a comprehensive testing protocol with appropriate precautions. Mothers infants were enrolled classified into an active infection group (mothers at delivery), postinfection recovered from during pregnancy), vaccinated pregnancy). Specimen collections, polymerase chain reaction assays, anti‐SARS‐CoV‐2 antibody measurements, examinations conducted for 6 months delivery. Results Sixty‐nine mothers 70 enrolled. SARS‐CoV‐2 was detected in placenta 22% 21% group. Neither nor SARS‐CoV‐2‐specific IgM infants. No anomalies, functional disorders, or developmental problems observed months. Compared group, there significant increase titers according number vaccinations, which maintained longer than first month life. Conclusions Vertical not despite protocol. more often placenta, appeared prevent vertical transmission. Maternal increased considered immunologically efficient. Vaccination pregnancy is important preventing congenital, neonatal, infantile COVID‐19.

Язык: Английский

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Can SARS-CoV-2 positive pregnant women affect the hearing of their newborns: A systematic review

American Journal of Otolaryngology, Год журнала: 2022, Номер 43(5), С. 103523 - 103523

Опубликована: Июнь 2, 2022

Язык: Английский

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Prevalence and clinical relevance of viraemia in viral respiratory tract infections: a systematic review

The Lancet Microbe, Год журнала: 2024, Номер unknown, С. 100967 - 100967

Опубликована: Сен. 1, 2024

Язык: Английский

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Updates on Auditory Outcomes of COVID-19 and Vaccine Side Effects: An Umbrella Review

Journal of Speech Language and Hearing Research, Год журнала: 2025, Номер 68(3), С. 1311 - 1332

Опубликована: Фев. 21, 2025

This umbrella review synthesizes and discusses systematic reviews (SRs) meta-analyses (MAs) on auditory outcomes associated with COVID-19 infection vaccination side effects. It is innovative in offering a comprehensive synthesis of evidence across adults infants while summarizing vaccine-related literature search followed the Preferred Reporting Items for Systematic Reviews Meta-Analyses 2020 guidelines, no restrictions population age or symptom severity. Four electronic databases were searched from their inception to October 2024. The Assessment Multiple 2 checklist Risk Bias tool used assess quality risk bias. identified 534 articles, narrowed down 14 SRs following full-text review: Nine focused COVID-19; two, born mothers infected during pregnancy; three, effects vaccination. A random-effects model revealed significantly high pooled estimates hearing loss (5.0%, 95% CI [1.0, 9.0], p < .012, three MAs, N = 21,932) tinnitus (13.5%, [5.9, 21.1], ≤ .001, four 36,236) adults. However, current nonhospitalized patients indicates that symptoms often improve after recovery. Studies also show low rate whose contracted pregnancy. Similarly, whereas has been linked tinnitus, these are rare, most experience improvement within weeks months. Evidence suggests adults, although remain rare newborns caution warranted due limitations variability studies.

Язык: Английский

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A comprehensive overview on the transmission, pathogenesis, diagnosis, treatment, and prevention of SARS‐CoV‐2

Journal of Medical Virology, Год журнала: 2023, Номер 95(5)

Опубликована: Май 1, 2023

Severe acute respiratory syndrome coronavirus (SARS-CoV) is a single positive-strand RNA virus that responsible for the current pandemic world has been facing since 2019. The primary route of transmission SARS-CoV-2 through tract transmission. However, other routes such as fecal-oral, vertical transmission, and aerosol-eye also exist. In addition, it found pathogenesis this involves binding virus's S protein to its host cell surface receptor angiotensin-converting enzyme 2, which results in subsequent membrane fusion required replicate complete entire life. clinical symptoms patients infected with can range from asymptomatic severe. most common seen include fever, dry cough, fatigue. Once these are observed, nucleic acid test done using reverse transcription-polymerase chain reaction. This currently serves main confirmatory tool COVID-19. Despite fact no cure SARS-CoV-2, prevention methods vaccines, specific facial mask, social distancing have proven be quite effective. It imperative understanding virus. To effectively develop new drugs well diagnostic tools, more knowledge about would needed.

Язык: Английский

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SARS-CoV2 Infection During Pregnancy Causes Persistent Immune Abnormalities in Women Without Affecting the Newborns

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Июль 14, 2022

SARS-CoV2 infection in pregnancy and exposed newborns is poorly known. We performed a longitudinal analysis of immune system determined soluble cytokine levels pregnant women infected with their newborns. Women confirmed uninfected were recruited from Hospital General Universitario Gregorio Marañón. Peripheral blood mononuclear cells (PBMCs), cord plasma collected at birth 6 months later. Immunophenotyping natural killer (NK), monocytes CD4/CD8 T-cells studied cryopreserved PBMCs by multiparametric flow cytometry. Up to 4 pro/anti-inflammatory cytokines assessed plasma/cord ELISA assay. SARS-CoV2-infected mothers compared matched healthy non-SARS-CoV2-infected The TNFα IL-10 higher baseline than those controls. Infected showed increased NK activation reduced expression maturation markers that reverted after months. They also had high Central Memory low Effector CD4-T cell subsets. Additionally, the CD4- CD8-T (CD154 CD38) exhaustion (TIM3/TIGIT) controls remained elevated Regarding Treg cells, lower but No newborn was birth. monocytes, observed SARS-CoV2-exposed unexposed significantly In conclusion, during shows differences immunological components could lead future clinical implications However, 6-months-old no misbalance, whereas maintain

Язык: Английский

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Neonatal outcomes of maternal prenatal coronavirus infection

Pediatric Research, Год журнала: 2023, Номер 95(2), С. 445 - 455

Опубликована: Дек. 6, 2023

Язык: Английский

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Anti-SARS-CoV-2-specific antibodies in human breast milk following SARS-CoV-2 infection during pregnancy: a prospective cohort study

International Breastfeeding Journal, Год журнала: 2024, Номер 19(1)

Опубликована: Янв. 18, 2024

Abstract Background While the presence of SARS-CoV-2 in human breast milk is contentious, anti-SARS-CoV-2 antibodies have been consistently detected milk. However, it uncertain when and how long are present. Methods This was a prospective cohort study including all consecutive pregnant women with confirmed infection during pregnancy, recruited at six maternity units Spain Hong Kong from March 2020 to 2021. Colostrum (day birth until day 4 postpartum) mature 7 postpartum 6 weeks were prospectively collected, paired maternal blood samples also collected. tested rRT-PCR-SARS-CoV-2, skimmed acellular sera against specific immunoglobulin M, A, G reactive receptor binding domain spike protein 1 determine immunoglobulins. Then, we examined each type colostrum related time by logistic regression analysis, concordance between these immunoglobulins colostrum, serum, Cohen's kappa statistic, relationship levels McNemar. Results One hundred eighty-seven pregnancy or childbirth donated samples. No found Immunoglobulin G, M present 129/162 (79·6%), 5/163 (3·1%), 15/76 (19·7%) 17/62 (27·42%), 2/62 (3·23%) samples, respectively. A predominant milk, its significantly higher than ( p -value < 0.001). We did not find that associated their maternal, severity disease, had occurred. Conclusions Since irrespective but virus itself our no indications withhold breastfeeding, taking contact precautions there active disease.

Язык: Английский

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