Anything but small: Microarousals stand at the crossroad between noradrenaline signaling and key sleep functions
Neuron,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Continuous
sleep
restores
the
brain
and
body,
whereas
fragmented
harms
cognition
health.
Microarousals
(MAs),
brief
(3-
to
15-s-long)
wake
intrusions
into
sleep,
are
clinical
markers
for
various
disorders.
Recent
rodent
studies
show
that
MAs
during
healthy
non-rapid
eye
movement
(NREM)
driven
by
infraslow
fluctuations
of
noradrenaline
(NA)
in
coordination
with
electrophysiological
rhythms,
vasomotor
activity,
cerebral
blood
volume,
glymphatic
flow.
hence
part
dynamics,
raising
questions
about
their
biological
roles.
We
propose
bolster
NREM
sleep's
benefits
associated
NA
fluctuations,
according
an
inverted
U-shaped
curve.
Weakened
noradrenergic
as
may
occur
neurodegenerative
diseases
or
aids,
reduce
MAs,
exacerbated
caused
stress
fragment
collapse
signaling.
suggest
crucial
restorative
plasticity-promoting
functions
advance
our
insight
normal
pathological
arousal
dynamics
from
sleep.
Язык: Английский
Exploring the Comprehensive Neuroprotective and Anticancer Potential of Afzelin
Pharmaceuticals,
Год журнала:
2024,
Номер
17(6), С. 701 - 701
Опубликована: Май 28, 2024
Neurodegenerative
diseases
(Alzheimer’s
disease,
Parkinson’s
Huntington’s
and
others)
cancer,
seemingly
disparate
in
their
etiology
manifestation,
exhibit
intriguing
associations
certain
cellular
molecular
processes.
Both
cancer
neurodegenerative
involve
the
deregulation
of
processes
such
as
apoptosis,
proliferation,
DNA
repair
pose
a
significant
global
health
challenge.
Afzelin
(kaempferol
3-O-rhamnoside)
is
flavonoid
compound
abundant
various
plant
sources.
exhibits
diverse
range
biological
activities,
offering
promising
prospects
for
treatment
hallmarked
by
oxidative
stress
cell
death
pathways.
Its
protective
potential
against
also
alleviating
side
effects
chemotherapy.
This
review
explores
therapeutic
implications
afzelin,
including
its
capacity
to
mitigate
stress,
modulate
inflammation,
promote
regeneration
diseases.
Язык: Английский
Riddles in the dark: Decoding the relationship between neuromelanin and neurodegeneration in locus coeruleus neurons
Neuroscience & Biobehavioral Reviews,
Год журнала:
2023,
Номер
152, С. 105287 - 105287
Опубликована: Июнь 15, 2023
Язык: Английский
Regenerating Locus Coeruleus‐Norepinephrine (LC‐NE) Function: A Novel Approach for Neurodegenerative Diseases
Cell Proliferation,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
ABSTRACT
Pathological
changes
in
the
locus
coeruleus‐norepinephrine
(LC‐NE)
neurons,
major
source
of
norepinephrine
(NE,
also
known
as
noradrenaline)
brain,
are
evident
during
early
stages
neurodegenerative
diseases
(ND).
Research
on
both
human
and
animal
models
have
highlighted
therapeutic
potential
targeting
LC‐NE
system
to
mitigate
progression
ND
alleviate
associated
psychiatric
symptoms.
However,
widespread
degeneration
presents
a
significant
challenge
for
direct
intervention
ND.
Recent
advances
regenerative
cell
therapy
offer
promising
new
strategies
treatment.
The
regeneration
from
pluripotent
stem
cells
(PSCs)
could
significantly
broaden
scope
LC‐NE‐based
therapies
In
this
review,
we
delve
into
fundamental
background
physiological
functions
LC‐NE.
Additionally,
systematically
examine
evidence
role
neuropathology
over
recent
years.
Notably,
focus
significance
PSCs‐derived
its
impact
therapy.
A
deeper
understanding
further
investigation
function
pave
way
practical
effective
treatments
Язык: Английский
Age-related differences in locus coeruleus intensity across a demographically diverse sample
Neurobiology of Aging,
Год журнала:
2025,
Номер
150, С. 122 - 131
Опубликована: Март 13, 2025
Язык: Английский
Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Март 10, 2023
Abstract
The
locus
coeruleus
(LC),
the
major
source
of
norepinephrine
(NE)
in
brain,
is
an
early
site
pathology
both
Alzheimer’s
disease
(AD)
and
Parkinson’s
(PD),
it
undergoes
catastrophic
degeneration
later
disorders.
Dysregulation
LC
thought
to
contribute
prodromal
symptoms
AD
PD
such
as
anxiety
sleep
disturbances,
while
frank
LC-NE
loss
promotes
cognitive
decline.
However,
mechanisms
responsible
for
its
selective
vulnerability
are
unknown.
among
only
structures
brain
that
produces
appreciable
amounts
neuromelanin
(NM),
a
dark
cytoplasmic
pigment.
It
has
been
proposed
NM
initially
plays
protective
role
by
sequestering
toxic
catecholamine
metabolites
heavy
metals,
but
may
become
harmful
during
aging
overwhelms
cellular
machinery
released
neurodegeneration.
Rodents
do
not
naturally
produce
NM,
limiting
study
causal
relationships
between
pathology.
Adapting
viral-mediated
approach
expression
human
tyrosinase,
enzyme
peripheral
melanin
production,
we
successfully
promoted
pigmentation
mouse
neurons
recapitulates
key
ultrastructural
features
endogenous
found
primates.
Pigment
results
neuron
hyperactivity,
reduced
tissue
NE
levels,
transcriptional
changes,
novelty-induced
phenotypes
1-week
post-injection.
By
6-10
weeks,
accumulation
associated
with
severe
neurodegeneration
microglial
engulfment
pigment
granules,
anxiety-like
behavior
abated.
These
reminiscent
dysfunction
cell
death
PD,
validating
this
model
studying
consequences
relates
neurodegenerative
disease.
Язык: Английский
Neuromodulatory systems in aging and disease
Neuroscience & Biobehavioral Reviews,
Год журнала:
2024,
Номер
162, С. 105647 - 105647
Опубликована: Апрель 2, 2024
Язык: Английский
Locus coeruleus neuromelanin accumulation and dissipation across the lifespan
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 19, 2023
Abstract
The
pigment
neuromelanin,
produced
in
the
locus
coeruleus
(LC)
as
a
byproduct
of
catecholamine
synthesis,
gives
“blue
spot”
its
name,
and
both
identifies
LC
neurons
is
thought
to
play
an
important
yet
complex
role
normal
pathological
aging.
Using
neuromelanin-sensitive
T1-weighted
turbo
spin
echo
MRI
scans
we
characterized
volume
neuromelanin
signal
intensity
96
participants
between
ages
19
86.
Although
did
not
change
significantly
throughout
lifespan,
increased
from
early
adulthood,
peaked
around
age
60
precipitously
declined
thereafter.
Neuromelanin
was
greater
caudal
relative
rostral
extent
women
men.
With
regard
function,
associated
with
fluid
cognition
older
adults
(60+)
only
those
above
50th
percentile
cognitive
ability
for
age.
gradual
accumulation
across
sudden
dissipation
later
life,
relation
preserved
consistent
Язык: Английский