Review of One Health in the Galápagos Islands (Part 1): historical perspective, invasive species, and emerging infectious diseases DOI Creative Commons
Isabel A. Jimenez, Patricio Vega-Mariño,

Tamia Villacres

и другие.

Frontiers in Conservation Science, Год журнала: 2024, Номер 5

Опубликована: Окт. 17, 2024

The Galápagos archipelago is a vast reservoir of terrestrial and marine biodiversity, owing in large part to its relatively recent volcanic genesis colonization by humans. This unique ecological system particularly susceptible human, animal, environmental impacts. Climate change, globalization, the blurring human-domestic animal-wildlife interfaces are poised bring new threats challenges region. A One Health perspective that simultaneously considers health imperative assessing mitigating facing Islands. In Part I this review, we provide historical context for biodiversity archipelago; discuss role invasive species habitat destruction, fragmentation, competition with endemic species; summarize established emerging infectious disease threats. We also implement research, surveillance, preventative measures identify manage future from perspective, specific emphasis on implications wildlife health. II outline socioeconomic life Islands, evaluate current predicted effects climate direct anthropogenic factors affecting such as tourism, fishing, pollution, illegal trade. examine impact COVID-19 pandemic build cohesive picture Islands integrating past work, needs, consider overarching goals conservation, ecosystem management, sustainability have been previously defined both governmental non-governmental stakeholders, discrete, implementable, interdisciplinary recommendations will facilitate achievement those goals.

Язык: Английский

Virology—the path forward DOI
Angela L. Rasmussen, Gigi Kwik Grönvall, Anice C. Lowen

и другие.

Journal of Virology, Год журнала: 2024, Номер 98(1)

Опубликована: Янв. 3, 2024

ABSTRACT In the United States (US), biosafety and biosecurity oversight of research on viruses is being reappraised. Safety in virology paramount frameworks should be reviewed periodically. Changes made with care, however, to avoid impeding science that essential for rapidly reducing responding pandemic threats as well addressing more common challenges caused by infectious diseases. Decades uniquely positioned US able respond COVID-19 crisis astounding speed, delivering life-saving vaccines within a year identifying virus. We embolden empower this strength, which vital part protecting health, economy, security citizens. Herein, we offer our perspectives priorities revised rules governing US.

Язык: Английский

Процитировано

8
Digital modeling by biomedical informatics analysis predicts suppression of COVID-19 infectivity via ‘targeting oligonucleotide-directed devolution’ DOI Creative Commons
Frank Hong, M. Castro, Klaus D. Linse

и другие.

Опубликована: Март 20, 2025

Aim: Genetic instability represents the hallmark of carcinogenesis. For cancer, retinoblastoma (RB) gene defect allowing genetic was successfully exploited to eliminate cancer. Similarly, this study aims assess severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein’s S1/S2 furin cleavage site in hopes applying oligonucleotide-based therapeutics suppress infectivity by exploiting hypermutability. Methods: The Basic Local Alignment Search Tool used search for homology. Protein or nucleotide sequences were obtained from National Center Biotechnology Information database. BioEdit multiple sequence alignment. Python-enhanced molecular graphics program modeling. Results: To feasibility, comparative alignment performed on plus juxtaposing residues SARS-CoV-2 and avian infectious bronchitis virus (IBV) isolate AL/7052/97 that belongs distinct genus. IBV amino acids correlating 678-TNSPRRARSVASQS protein deciphered (nine identical, two conserved, displaced, one unconserved). encoding nucleotides exhibited 14 identities, three transitions (C>U U>C, two; G>A A>G, one), 15 transversions (U>A A>U, eight; C>G G>C, six; G>U U>G, one) with mostly complementary base (14/15) transversion. Analysis variants corroborates continues evolve. overall data portrays an evolutionarily dynamic nature site. potential role intragenomic ‘microhomology-mediated template switching’ RNA-dependent RNA polymerase is described. Conclusions: apply virolytic pressure, peptide-guided oligonucleotides targeting site-encoding may be deployed trigger genomic degradation. A consequence resistant (if emerge) carry mutation(s) abrogate hybridization, which (by default) encode defective substrate furin. Thus, through ‘targeting directed devolution’ site, attenuated. An alternative strategy therapeutic editing adenosine deaminases acting (ADAR) mentioned.

Язык: Английский

Процитировано

0
A critical reexamination of recovered SARS-CoV-2 sequencing data DOI Creative Commons
Florence Débarre, Zach Hensel

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 16, 2024

Abstract SARS-CoV-2 genomes collected at the onset of Covid-19 pandemic are valuable because they could help understand how virus entered human population. In 2021, Jesse Bloom reported on recovery a dataset raw sequencing reads that had been removed from NCBI SRA database request data generators, scientific team Wuhan University (Wang et al ., 2020b). concluded deletion obfuscated origin and suggested may have requested to comply with government order; further, he questioned sample collection dates after January 30, 2020. Here, we show were published in 2020 by Wang . together reads, match given authors 2021. Collection manually during his analysis data. We examine mutations these sequences confirm entirely consistent previously known genetic diversity late Finally, explain an apparent phylogenetic rooting paradox described was resolved subsequent analysis. Our reanalysis demonstrates there no basis question .. Note for bioRxiv readers The automatically generated Full Text version our manuscript is missing footnotes; available PDF version.

Язык: Английский

Процитировано

1
Review of One Health in the Galápagos Islands (Part 1): Historical Perspective, Invasive Species, and Emerging Infectious Diseases DOI Open Access
Isabel A. Jimenez, Patricio Vega-Mariño,

Tamia Villacres

и другие.

Опубликована: Авг. 16, 2024

The Galápagos archipelago is a vast reservoir of terrestrial and marine biodiversity, owing in large part to its relatively recent volcanic genesis colonization by humans. This unique ecological system particularly susceptible human, animal, environmental impacts. Climate change, globalization, the blurring human-domestic animal-wildlife interfaces are poised bring new threats challenges region. A One Health perspective that simultaneously considers health imperative assessing mitigating facing Islands.In Part I this review, we provide historical context for biodiversity archipelago; discuss role invasive species habitat destruction, fragmentation, competition with endemic species; summarize established emerging infectious disease threats. We also implement research, surveillance, preventative measures identify manage future from perspective, specific emphasis on implications wildlife health. In II, outline socioeconomic life Islands, evaluate current predicted effects climate direct anthropogenic factors affecting such as tourism, fishing, pollution, illegal trade. examine impact COVID-19 pandemic Throughout two-part build cohesive picture Islands integrating past work, needs, consider overarching goals conservation, ecosystem management, sustainability have been previously defined both governmental non-governmental stakeholders, discrete, implementable, interdisciplinary recommendations will facilitate achievement those goals.

Язык: Английский

Процитировано

1
The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease DOI Creative Commons
Agnes Carolin, David M. Frazer, Kexin Yan

и другие.

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Сен. 4, 2024

The severity of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often dictated a range comorbidities. A considerable literature suggests iron deficiency and overload may contribute to increased infection, inflammation severity, although direct causal relationships have been difficult establish.

Язык: Английский

Процитировано

1
Navigating Evolving Challenges in Blood Safety DOI Creative Commons
Mahmoud Reza Pourkarim

Viruses, Год журнала: 2024, Номер 16(1), С. 123 - 123

Опубликована: Янв. 15, 2024

Blood safety remains a paramount public health concern, and authorities maintain high level of vigilance to prevent transfusion-transmitted infections (TTIs) [...]

Язык: Английский

Процитировано

0
The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease DOI Creative Commons
Agnes Carolin, David M. Frazer, Kexin Yan

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 29, 2024

Abstract The severity of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often dictated a range comorbidities. A considerable literature suggests iron deficiency and overload may contribute to increased infection, inflammation severity, although direct causal relationships have been difficult establish. Here we generate deficient loaded C57BL/6J mice feeding low high diets, with on normal diet representing controls. All were infected primary omicron XXB SARS-CoV-2 isolate lung inflammatory responses analyzed histology, immunohistochemistry RNA-Seq. Compared controls, showed no significant changes in viral loads or histopathology, whereas, slightly, but significantly, reduced histopathology. Transcriptional modest, illustrated widespread dysregulation signatures for both vs. Some these could be associated detrimental outcomes, whereas others would viewed as beneficial. Diet-associated thus induced modest modulations signatures, histopathologically detectable exacerbations. Author summary can lead anemia, problem worldwide. excessive less common, consumption supplements. We investigate herein using mouse model, whether diets predispose outcomes lungs after infection SARS-CoV-2. promote inflammation. However, found, modulations, unaffected slightly reduced, histopathology was either indicated disease. These findings do not support view that represent comorbidities predisposing overt COVID-19

Язык: Английский

Процитировано

0
Review of One Health in the Galápagos Islands (Part 1): historical perspective, invasive species, and emerging infectious diseases DOI Creative Commons
Isabel A. Jimenez, Patricio Vega-Mariño,

Tamia Villacres

и другие.

Frontiers in Conservation Science, Год журнала: 2024, Номер 5

Опубликована: Окт. 17, 2024

The Galápagos archipelago is a vast reservoir of terrestrial and marine biodiversity, owing in large part to its relatively recent volcanic genesis colonization by humans. This unique ecological system particularly susceptible human, animal, environmental impacts. Climate change, globalization, the blurring human-domestic animal-wildlife interfaces are poised bring new threats challenges region. A One Health perspective that simultaneously considers health imperative assessing mitigating facing Islands. In Part I this review, we provide historical context for biodiversity archipelago; discuss role invasive species habitat destruction, fragmentation, competition with endemic species; summarize established emerging infectious disease threats. We also implement research, surveillance, preventative measures identify manage future from perspective, specific emphasis on implications wildlife health. II outline socioeconomic life Islands, evaluate current predicted effects climate direct anthropogenic factors affecting such as tourism, fishing, pollution, illegal trade. examine impact COVID-19 pandemic build cohesive picture Islands integrating past work, needs, consider overarching goals conservation, ecosystem management, sustainability have been previously defined both governmental non-governmental stakeholders, discrete, implementable, interdisciplinary recommendations will facilitate achievement those goals.

Язык: Английский

Процитировано

0