The brain’s action-mode network
Nature reviews. Neuroscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 2, 2025
Язык: Английский
Propofol anesthesia destabilizes neural dynamics across cortex
Neuron,
Год журнала:
2024,
Номер
112(16), С. 2799 - 2813.e9
Опубликована: Июль 15, 2024
Every
day,
hundreds
of
thousands
people
undergo
general
anesthesia.
One
hypothesis
is
that
anesthesia
disrupts
dynamic
stability-the
ability
the
brain
to
balance
excitability
with
need
be
stable
and
controllable.
To
test
this
hypothesis,
we
developed
a
method
for
quantifying
changes
in
population-level
stability
complex
systems:
delayed
linear
analysis
estimation
(DeLASE).
Propofol
was
used
transition
animals
between
awake
state
anesthetized
unconsciousness.
DeLASE
applied
macaque
cortex
local
field
potentials
(LFPs).
We
found
neural
dynamics
were
more
unstable
unconsciousness
compared
state.
Cortical
trajectories
mirrored
predictions
from
destabilized
systems.
mimicked
effect
propofol
simulated
networks
by
increasing
inhibitory
tone.
This
turn
networks,
as
observed
data.
Our
results
suggest
dynamical
required
consciousness.
Язык: Английский
The predictive nature of spontaneous brain activity across scales and species
Neuron,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
A cortical locus for modulation of arousal states
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 26, 2024
Fluctuations
in
global
arousal
are
key
determinants
of
spontaneous
cortical
activity
and
function.
Several
subcortical
structures,
including
neuromodulator
nuclei
like
the
locus
coeruleus
(LC),
involved
regulation
arousal.
However,
much
less
is
known
about
role
circuits
that
provide
top-down
inputs
to
arousal-related
structures.
Here,
we
investigated
a
major
subdivision
prefrontal
cortex,
anterior
cingulate
cortex
(ACC),
modulation.
Pupil
size,
facial
movements,
heart
rate,
locomotion
were
used
as
non-invasive
measures
behavioral
state.
We
designed
closed
loop
optogenetic
system
based
on
machine
vision
found
real
time
inhibition
ACC
during
pupil
dilations
suppresses
ongoing
events.
In
contrast,
inhibiting
control
region
had
no
effect
Fiber
photometry
recordings
showed
scales
with
magnitude
spontaneously
occurring
dilations/face
movements
independently
locomotion.
Moreover,
activation
increases
addition
modulating
arousal,
responses
salient
sensory
stimuli
scaled
size
evoked
dilations.
Consistent
sustaining
saliency-linked
events,
suppressed
inactivation.
Finally,
our
results
comparing
norepinephrinergic
LC
neuron
support
for
initiation
events
which
modulated
by
ACC.
Collectively,
experiments
identify
site
momentary
foundation
understanding
cortical-subcortical
dynamics
underlying
modulation
states.
Язык: Английский
Transcriptome analysis of the effects of high temperature on zygotic genome activation in porcine embryos
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Сен. 19, 2024
Язык: Английский
Arousal as a universal embedding for spatiotemporal brain dynamics
Опубликована: Дек. 22, 2023
Neural
activity
in
awake
organisms
shows
widespread
and
spatiotemporally
diverse
correlations
with
behavioral
physiological
measurements.
We
propose
that
this
covariation
reflects
part
the
dynamics
of
a
unified,
arousal-related
process
regulates
brain-wide
physiology
on
timescale
seconds.
Taken
together
theoretical
foundations
dynamical
systems,
interpretation
leads
us
to
surprising
prediction:
single,
scalar
measurement
arousal
(e.g.,
pupil
diameter)
should
suffice
reconstruct
continuous
evolution
multimodal,
spatiotemporal
measurements
large-scale
brain
physiology.
To
test
hypothesis,
we
perform
cortex-wide
optical
imaging
monitoring
mice.
demonstrate
neuronal
calcium,
metabolism,
blood-oxygen
can
be
accurately
parsimoniously
modeled
from
low-dimensional
state-space
reconstructed
time
history
diameter.
Extending
framework
electrophysiological
Allen
Brain
Observatory,
ability
integrate
experimental
data
into
unified
generative
model
via
mappings
an
intrinsic
manifold.
Our
results
support
hypothesis
spontaneous,
spatially
structured
fluctuations
physiology—widely
interpreted
reflect
regionally-specific
neural
communication—are
large
reflections
process.
This
enriched
view
has
broad
implications
for
interpreting
observations
brain,
body,
behavior
as
measured
across
modalities,
contexts,
scales.
Язык: Английский