Arousal as a universal embedding for spatiotemporal brain dynamics DOI
Ryan V. Raut

Published: Dec. 22, 2023

Neural activity in awake organisms shows widespread and spatiotemporally diverse correlations with behavioral physiological measurements. We propose that this covariation reflects part the dynamics of a unified, arousal-related process regulates brain-wide physiology on timescale seconds. Taken together theoretical foundations dynamical systems, interpretation leads us to surprising prediction: single, scalar measurement arousal (e.g., pupil diameter) should suffice reconstruct continuous evolution multimodal, spatiotemporal measurements large-scale brain physiology. To test hypothesis, we perform cortex-wide optical imaging monitoring mice. demonstrate neuronal calcium, metabolism, blood-oxygen can be accurately parsimoniously modeled from low-dimensional state-space reconstructed time history diameter. Extending framework electrophysiological Allen Brain Observatory, ability integrate experimental data into unified generative model via mappings an intrinsic manifold. Our results support hypothesis spontaneous, spatially structured fluctuations physiology—widely interpreted reflect regionally-specific neural communication—are large reflections process. This enriched view has broad implications for interpreting observations brain, body, behavior as measured across modalities, contexts, scales.

Language: Английский

The brain’s action-mode network DOI
Nico U.F. Dosenbach,

Marcus E. Raichle,

Evan M. Gordon

et al.

Nature reviews. Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

Citations

12
Propofol anesthesia destabilizes neural dynamics across cortex DOI Creative Commons
Adam Eisen, Leo Kozachkov, André M. Bastos

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(16), P. 2799 - 2813.e9

Published: July 15, 2024

Every day, hundreds of thousands people undergo general anesthesia. One hypothesis is that anesthesia disrupts dynamic stability-the ability the brain to balance excitability with need be stable and controllable. To test this hypothesis, we developed a method for quantifying changes in population-level stability complex systems: delayed linear analysis estimation (DeLASE). Propofol was used transition animals between awake state anesthetized unconsciousness. DeLASE applied macaque cortex local field potentials (LFPs). We found neural dynamics were more unstable unconsciousness compared state. Cortical trajectories mirrored predictions from destabilized systems. mimicked effect propofol simulated networks by increasing inhibitory tone. This turn networks, as observed data. Our results suggest dynamical required consciousness.

Language: Английский

Citations

7
The predictive nature of spontaneous brain activity across scales and species DOI Creative Commons
Anastasia Dimakou, Giovanni Pezzulo, Andrea Zangrossi

et al.

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
A cortical locus for modulation of arousal states DOI Creative Commons

Nithik Chintalacheruvu,

Anagha Kalelkar,

Joël Boutin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 26, 2024

Fluctuations in global arousal are key determinants of spontaneous cortical activity and function. Several subcortical structures, including neuromodulator nuclei like the locus coeruleus (LC), involved regulation arousal. However, much less is known about role circuits that provide top-down inputs to arousal-related structures. Here, we investigated a major subdivision prefrontal cortex, anterior cingulate cortex (ACC), modulation. Pupil size, facial movements, heart rate, locomotion were used as non-invasive measures behavioral state. We designed closed loop optogenetic system based on machine vision found real time inhibition ACC during pupil dilations suppresses ongoing events. In contrast, inhibiting control region had no effect Fiber photometry recordings showed scales with magnitude spontaneously occurring dilations/face movements independently locomotion. Moreover, activation increases addition modulating arousal, responses salient sensory stimuli scaled size evoked dilations. Consistent sustaining saliency-linked events, suppressed inactivation. Finally, our results comparing norepinephrinergic LC neuron support for initiation events which modulated by ACC. Collectively, experiments identify site momentary foundation understanding cortical-subcortical dynamics underlying modulation states.

Language: Английский

Citations

1
Transcriptome analysis of the effects of high temperature on zygotic genome activation in porcine embryos DOI Creative Commons
Ming‐Hong Sun,

Cheng‐Lin Zhan,

Xiao‐Han Li

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 19, 2024

Language: Английский

Citations

1
Arousal as a universal embedding for spatiotemporal brain dynamics DOI
Ryan V. Raut

Published: Dec. 22, 2023

Neural activity in awake organisms shows widespread and spatiotemporally diverse correlations with behavioral physiological measurements. We propose that this covariation reflects part the dynamics of a unified, arousal-related process regulates brain-wide physiology on timescale seconds. Taken together theoretical foundations dynamical systems, interpretation leads us to surprising prediction: single, scalar measurement arousal (e.g., pupil diameter) should suffice reconstruct continuous evolution multimodal, spatiotemporal measurements large-scale brain physiology. To test hypothesis, we perform cortex-wide optical imaging monitoring mice. demonstrate neuronal calcium, metabolism, blood-oxygen can be accurately parsimoniously modeled from low-dimensional state-space reconstructed time history diameter. Extending framework electrophysiological Allen Brain Observatory, ability integrate experimental data into unified generative model via mappings an intrinsic manifold. Our results support hypothesis spontaneous, spatially structured fluctuations physiology—widely interpreted reflect regionally-specific neural communication—are large reflections process. This enriched view has broad implications for interpreting observations brain, body, behavior as measured across modalities, contexts, scales.

Language: Английский

Citations

3