Tissue Engineering Part B Reviews,
Год журнала:
2014,
Номер
20(6), С. 683 - 696
Опубликована: Июнь 13, 2014
Type
I
collagen
hydrogels
have
been
used
successfully
as
three-dimensional
substrates
for
cell
culture
and
shown
promise
scaffolds
engineered
tissues
tumors.
A
critical
step
in
the
development
of
viable
tissue
mimics
is
quantitative
characterization
hydrogel
properties
their
correlation
with
fabrication
parameters,
which
enables
to
be
tuned
match
specific
or
fulfill
engineering
requirements.
significant
body
work
has
devoted
hydrogels;
however,
due
breadth
materials
techniques
characterization,
published
data
are
often
disjoint
hence
utility
community
reduced.
This
review
aims
determine
parameter
space
covered
by
existing
identify
key
gaps
literature
so
that
future
use
research
can
most
efficiently
conducted.
divided
into
three
sections:
(1)
relevant
parameters
introduced
several
popular
methods
controlling
regulating
them
described,
(2)
presented
discussed
along
techniques,
(3)
state
recapitulated
directions
proposed.
Ultimately,
this
serve
a
resource
selection
material
methodologies
order
increase
usefulness
collagen-hydrogel-based
studies
experiments.
The Journal of Cell Biology,
Год журнала:
2012,
Номер
196(4), С. 395 - 406
Опубликована: Фев. 20, 2012
The
local
microenvironment,
or
niche,
of
a
cancer
cell
plays
important
roles
in
development.
A
major
component
the
niche
is
extracellular
matrix
(ECM),
complex
network
macromolecules
with
distinctive
physical,
biochemical,
and
biomechanical
properties.
Although
tightly
controlled
during
embryonic
development
organ
homeostasis,
ECM
commonly
deregulated
becomes
disorganized
diseases
such
as
cancer.
Abnormal
affects
progression
by
directly
promoting
cellular
transformation
metastasis.
Importantly,
however,
anomalies
also
deregulate
behavior
stromal
cells,
facilitate
tumor-associated
angiogenesis
inflammation,
thus
lead
to
generation
tumorigenic
microenvironment.
Understanding
how
composition
topography
are
maintained
their
deregulation
influences
may
help
develop
new
therapeutic
interventions
targeting
tumor
niche.
Cold Spring Harbor Perspectives in Biology,
Год журнала:
2011,
Номер
3(12), С. a005058 - a005058
Опубликована: Сен. 14, 2011
Pengfei
Lu1,2,
Ken
Takai2,
Valerie
M.
Weaver3
and
Zena
Werb2
Breakthrough
Breast
Cancer
Research
Unit,
Paterson
Institute
for
Wellcome
Trust
Centre
Cell
Matrix
Research,
Faculty
of
Life
Sciences,
University
Manchester,
Manchester
M20
4BX,
United
Kingdom
Department
Anatomy
Program
in
Developmental
Biology,
California,
San
Francisco,
California
94143-0452
Surgery
Center
Bioengineering
Tissue
Regeneration,
94143
Correspondence:
zena.werb{at}ucsf.edu
Chemical Reviews,
Год журнала:
2015,
Номер
115(24), С. 13165 - 13307
Опубликована: Дек. 8, 2015
In
this
review
we
intend
to
provide
a
relatively
comprehensive
summary
of
the
work
supramolecular
hydrogelators
after
2004
and
put
emphasis
particularly
on
applications
hydrogels/hydrogelators
as
molecular
biomaterials.
After
brief
introduction
methods
for
generating
hydrogels,
discuss
basis
their
categories,
such
small
organic
molecules,
coordination
complexes,
peptides,
nucleobases,
saccharides.
Following
design,
focus
various
potential
hydrogels
biomaterials,
classified
by
in
cell
cultures,
tissue
engineering,
behavior,
imaging,
unique
hydrogelators.
Particularly,
they
form
assemblies
but
prior
reaching
critical
gelation
concentration
because
subject
is
less
explored
may
hold
equally
great
promise
helping
address
fundamental
questions
about
mechanisms
or
consequences
self-assembly
including
low
weight
ones.
Finally,
perspective
We
hope
that
will
serve
an
updated
reference
researchers
who
are
interested
exploring
biomaterials
addressing
societal
needs
at
frontiers.
Nature Communications,
Год журнала:
2020,
Номер
11(1)
Опубликована: Окт. 9, 2020
Abstract
Tissues
are
dynamically
shaped
by
bidirectional
communication
between
resident
cells
and
the
extracellular
matrix
(ECM)
through
cell-matrix
interactions
ECM
remodelling.
Tumours
leverage
remodelling
to
create
a
microenvironment
that
promotes
tumourigenesis
metastasis.
In
this
review,
we
focus
on
how
tumour
tumour-associated
stromal
deposit,
biochemically
biophysically
modify,
degrade
ECM.
These
tumour-driven
changes
support
growth,
increase
migration
of
cells,
remodel
in
distant
organs
allow
for
metastatic
progression.
A
better
understanding
underlying
mechanisms
tumourigenic
is
crucial
developing
therapeutic
treatments
patients.
Signal Transduction and Targeted Therapy,
Год журнала:
2020,
Номер
5(1)
Опубликована: Фев. 7, 2020
Abstract
Since
cancer
stem
cells
(CSCs)
were
first
identified
in
leukemia
1994,
they
have
been
considered
promising
therapeutic
targets
for
therapy.
These
self-renewal
capacity
and
differentiation
potential
contribute
to
multiple
tumor
malignancies,
such
as
recurrence,
metastasis,
heterogeneity,
multidrug
resistance,
radiation
resistance.
The
biological
activities
of
CSCs
are
regulated
by
several
pluripotent
transcription
factors,
OCT4,
Sox2,
Nanog,
KLF4,
MYC.
In
addition,
many
intracellular
signaling
pathways,
Wnt,
NF-κB
(nuclear
factor-κB),
Notch,
Hedgehog,
JAK-STAT
(Janus
kinase/signal
transducers
activators
transcription),
PI3K/AKT/mTOR
(phosphoinositide
3-kinase/AKT/mammalian
target
rapamycin),
TGF
(transforming
growth
factor)/SMAD,
PPAR
(peroxisome
proliferator-activated
receptor),
well
extracellular
vascular
niches,
hypoxia,
tumor-associated
macrophages,
cancer-associated
fibroblasts,
mesenchymal
cells,
matrix,
exosomes,
shown
be
very
important
regulators
CSCs.
Molecules,
vaccines,
antibodies,
CAR-T
(chimeric
antigen
receptor
T
cell)
developed
specifically
CSCs,
some
these
factors
already
undergoing
clinical
trials.
This
review
summarizes
the
characterization
identification
depicts
major
pathways
that
regulate
CSC
development,
discusses
targeted
therapy
Cell Communication and Signaling,
Год журнала:
2020,
Номер
18(1)
Опубликована: Апрель 7, 2020
Abstract
The
dynamic
interactions
of
cancer
cells
with
their
microenvironment
consisting
stromal
(cellular
part)
and
extracellular
matrix
(ECM)
components
(non-cellular)
is
essential
to
stimulate
the
heterogeneity
cell,
clonal
evolution
increase
multidrug
resistance
ending
in
cell
progression
metastasis.
reciprocal
cell-cell/ECM
interaction
tumor
hijacking
non-malignant
force
lose
function
acquire
new
phenotypes
that
promote
development
invasion
cells.
Understanding
underlying
cellular
molecular
mechanisms
governing
these
can
be
used
as
a
novel
strategy
indirectly
disrupt
interplay
contribute
efficient
safe
therapeutic
strategies
fight
cancer.
Furthermore,
tumor-derived
circulating
materials
also
diagnostic
tools
precisely
predict
monitor
outcome
therapy.
This
review
evaluates
such
potentials
various
advanced
models,
focus
on
3D
systems
well
lab-on-chip
devices.
