Review of Collagen I Hydrogels for Bioengineered Tissue Microenvironments: Characterization of Mechanics, Structure, and Transport DOI
Elizabeth E. Antoine, Pavlos P. Vlachos,

Marissa Nichole Rylander

et al.

Tissue Engineering Part B Reviews, Journal Year: 2014, Volume and Issue: 20(6), P. 683 - 696

Published: June 13, 2014

Type I collagen hydrogels have been used successfully as three-dimensional substrates for cell culture and shown promise scaffolds engineered tissues tumors. A critical step in the development of viable tissue mimics is quantitative characterization hydrogel properties their correlation with fabrication parameters, which enables to be tuned match specific or fulfill engineering requirements. significant body work has devoted hydrogels; however, due breadth materials techniques characterization, published data are often disjoint hence utility community reduced. This review aims determine parameter space covered by existing identify key gaps literature so that future use research can most efficiently conducted. divided into three sections: (1) relevant parameters introduced several popular methods controlling regulating them described, (2) presented discussed along techniques, (3) state recapitulated directions proposed. Ultimately, this serve a resource selection material methodologies order increase usefulness collagen-hydrogel-based studies experiments.

Language: Английский

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment DOI Creative Commons
Douglas Hanahan, Lisa M. Coussens

Cancer Cell, Journal Year: 2012, Volume and Issue: 21(3), P. 309 - 322

Published: March 1, 2012

Language: Английский

Citations

4193

Remodelling the extracellular matrix in development and disease DOI

Caroline Bonnans,

Jonathan Chou, Zena Werb

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2014, Volume and Issue: 15(12), P. 786 - 801

Published: Nov. 21, 2014

Language: Английский

Citations

3703

The extracellular matrix: A dynamic niche in cancer progression DOI Creative Commons
Pengfei Lu, Valerie M. Weaver, Zena Werb

et al.

The Journal of Cell Biology, Journal Year: 2012, Volume and Issue: 196(4), P. 395 - 406

Published: Feb. 20, 2012

The local microenvironment, or niche, of a cancer cell plays important roles in development. A major component the niche is extracellular matrix (ECM), complex network macromolecules with distinctive physical, biochemical, and biomechanical properties. Although tightly controlled during embryonic development organ homeostasis, ECM commonly deregulated becomes disorganized diseases such as cancer. Abnormal affects progression by directly promoting cellular transformation metastasis. Importantly, however, anomalies also deregulate behavior stromal cells, facilitate tumor-associated angiogenesis inflammation, thus lead to generation tumorigenic microenvironment. Understanding how composition topography are maintained their deregulation influences may help develop new therapeutic interventions targeting tumor niche.

Language: Английский

Citations

2740

Extracellular Matrix Degradation and Remodeling in Development and Disease DOI Open Access
Pengfei Lu, Ken Takai, Valerie M. Weaver

et al.

Cold Spring Harbor Perspectives in Biology, Journal Year: 2011, Volume and Issue: 3(12), P. a005058 - a005058

Published: Sept. 14, 2011

Pengfei Lu1,2, Ken Takai2, Valerie M. Weaver3 and Zena Werb2 Breakthrough Breast Cancer Research Unit, Paterson Institute for Wellcome Trust Centre Cell Matrix Research, Faculty of Life Sciences, University Manchester, Manchester M20 4BX, United Kingdom Department Anatomy Program in Developmental Biology, California, San Francisco, California 94143-0452 Surgery Center Bioengineering Tissue Regeneration, 94143 Correspondence: zena.werb{at}ucsf.edu

Language: Английский

Citations

2009

Mechanotransduction and extracellular matrix homeostasis DOI
Jay D. Humphrey, Eric R. Dufresne, Martin A. Schwartz

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2014, Volume and Issue: 15(12), P. 802 - 812

Published: Oct. 22, 2014

Language: Английский

Citations

1817

Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials DOI Creative Commons

Xuewen Du,

Jie Zhou, Junfeng Shi

et al.

Chemical Reviews, Journal Year: 2015, Volume and Issue: 115(24), P. 13165 - 13307

Published: Dec. 8, 2015

In this review we intend to provide a relatively comprehensive summary of the work supramolecular hydrogelators after 2004 and put emphasis particularly on applications hydrogels/hydrogelators as molecular biomaterials. After brief introduction methods for generating hydrogels, discuss basis their categories, such small organic molecules, coordination complexes, peptides, nucleobases, saccharides. Following design, focus various potential hydrogels biomaterials, classified by in cell cultures, tissue engineering, behavior, imaging, unique hydrogelators. Particularly, they form assemblies but prior reaching critical gelation concentration because subject is less explored may hold equally great promise helping address fundamental questions about mechanisms or consequences self-assembly including low weight ones. Finally, perspective We hope that will serve an updated reference researchers who are interested exploring biomaterials addressing societal needs at frontiers.

Language: Английский

Citations

1685

Concepts of extracellular matrix remodelling in tumour progression and metastasis DOI Creative Commons
Juliane Winkler, Abisola Abisoye-Ogunniyan, Kevin J. Metcalf

et al.

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: Oct. 9, 2020

Abstract Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions ECM remodelling. Tumours leverage remodelling to create a microenvironment that promotes tumourigenesis metastasis. In this review, we focus on how tumour tumour-associated stromal deposit, biochemically biophysically modify, degrade ECM. These tumour-driven changes support growth, increase migration of cells, remodel in distant organs allow for metastatic progression. A better understanding underlying mechanisms tumourigenic is crucial developing therapeutic treatments patients.

Language: Английский

Citations

1622

Targeting cancer stem cell pathways for cancer therapy DOI Creative Commons
Liqun Yang, Pengfei Shi,

Gaichao Zhao

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: Feb. 7, 2020

Abstract Since cancer stem cells (CSCs) were first identified in leukemia 1994, they have been considered promising therapeutic targets for therapy. These self-renewal capacity and differentiation potential contribute to multiple tumor malignancies, such as recurrence, metastasis, heterogeneity, multidrug resistance, radiation resistance. The biological activities of CSCs are regulated by several pluripotent transcription factors, OCT4, Sox2, Nanog, KLF4, MYC. In addition, many intracellular signaling pathways, Wnt, NF-κB (nuclear factor-κB), Notch, Hedgehog, JAK-STAT (Janus kinase/signal transducers activators transcription), PI3K/AKT/mTOR (phosphoinositide 3-kinase/AKT/mammalian target rapamycin), TGF (transforming growth factor)/SMAD, PPAR (peroxisome proliferator-activated receptor), well extracellular vascular niches, hypoxia, tumor-associated macrophages, cancer-associated fibroblasts, mesenchymal cells, matrix, exosomes, shown be very important regulators CSCs. Molecules, vaccines, antibodies, CAR-T (chimeric antigen receptor T cell) developed specifically CSCs, some these factors already undergoing clinical trials. This review summarizes the characterization identification depicts major pathways that regulate CSC development, discusses targeted therapy

Language: Английский

Citations

1541

Tumor microenvironment complexity and therapeutic implications at a glance DOI Creative Commons
Roghayyeh Baghban, Leila Roshangar, Rana Jahanban-­Esfahlan

et al.

Cell Communication and Signaling, Journal Year: 2020, Volume and Issue: 18(1)

Published: April 7, 2020

Abstract The dynamic interactions of cancer cells with their microenvironment consisting stromal (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to stimulate the heterogeneity cell, clonal evolution increase multidrug resistance ending in cell progression metastasis. reciprocal cell-cell/ECM interaction tumor hijacking non-malignant force lose function acquire new phenotypes that promote development invasion cells. Understanding underlying cellular molecular mechanisms governing these can be used as a novel strategy indirectly disrupt interplay contribute efficient safe therapeutic strategies fight cancer. Furthermore, tumor-derived circulating materials also diagnostic tools precisely predict monitor outcome therapy. This review evaluates such potentials various advanced models, focus on 3D systems well lab-on-chip devices.

Language: Английский

Citations

1405

Molecular and cellular mechanisms of liver fibrosis and its regression DOI
Tatiana Kisseleva, David A. Brenner

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2020, Volume and Issue: 18(3), P. 151 - 166

Published: Oct. 30, 2020

Language: Английский

Citations

1322