Cells,
Год журнала:
2019,
Номер
8(9), С. 1055 - 1055
Опубликована: Сен. 8, 2019
The
generation
of
reducing
equivalent
NADPH
via
glucose-6-phosphate
dehydrogenase
(G6PD)
is
critical
for
the
maintenance
redox
homeostasis
and
reductive
biosynthesis
in
cells.
also
plays
key
roles
cellular
processes
mediated
by
signaling.
Insufficient
G6PD
activity
predisposes
cells
to
growth
retardation
demise.
Severely
lacking
impairs
embryonic
development
delays
organismal
growth.
Altered
associated
with
pathophysiology,
such
as
autophagy,
insulin
resistance,
infection,
inflammation,
well
diabetes
hypertension.
Aberrant
activation
leads
enhanced
cell
proliferation
adaptation
many
types
cancers.
present
review
aims
update
existing
knowledge
concerning
emphasizes
how
modulates
signaling
affects
survival
demise,
particularly
diseases
cancer.
Exploiting
a
potential
drug
target
against
cancer
discussed.
Cell Death and Differentiation,
Год журнала:
2018,
Номер
25(3), С. 486 - 541
Опубликована: Янв. 23, 2018
Over
the
past
decade,
Nomenclature
Committee
on
Cell
Death
(NCCD)
has
formulated
guidelines
for
definition
and
interpretation
of
cell
death
from
morphological,
biochemical,
functional
perspectives.
Since
field
continues
to
expand
novel
mechanisms
that
orchestrate
multiple
pathways
are
unveiled,
we
propose
an
updated
classification
subroutines
focusing
mechanistic
essential
(as
opposed
correlative
dispensable)
aspects
process.
As
provide
molecularly
oriented
definitions
terms
including
intrinsic
apoptosis,
extrinsic
mitochondrial
permeability
transition
(MPT)-driven
necrosis,
necroptosis,
ferroptosis,
pyroptosis,
parthanatos,
entotic
death,
NETotic
lysosome-dependent
autophagy-dependent
immunogenic
cellular
senescence,
mitotic
catastrophe,
discuss
utility
neologisms
refer
highly
specialized
instances
these
processes.
The
mission
NCCD
is
a
widely
accepted
nomenclature
in
support
continued
development
field.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2019,
Номер
2019, С. 1 - 13
Опубликована: Окт. 13, 2019
Reactive
oxygen
species-
(ROS-)
induced
lipid
peroxidation
plays
a
critical
role
in
cell
death
including
apoptosis,
autophagy,
and
ferroptosis.
This
fundamental
conserved
mechanism
is
based
on
an
excess
of
ROS
which
attacks
biomembranes,
propagates
chain
reactions,
subsequently
induces
different
types
death.
A
highly
evolved
sophisticated
antioxidant
system
exists
that
acts
to
protect
the
cells
from
oxidative
damage.
In
this
review,
we
discussed
how
propagate
reactions
products
initiate
apoptosis
autophagy
current
models.
We
also
during
ferroptosis,
summarized
pathological
conditions
illness.
aim
bring
more
global
integrative
sight
know
ROS-induced
occurs
among
Cold Spring Harbor Perspectives in Biology,
Год журнала:
2012,
Номер
4(3), С. a006049 - a006049
Опубликована: Янв. 31, 2012
Kim
Newton
and
Vishva
M.
Dixit
Department
of
Physiological
Chemistry,
Genentech,
Inc.,
South
San
Francisco,
California
94080
Correspondence:
dixit{at}gene.com
International Journal of Molecular Sciences,
Год журнала:
2018,
Номер
19(2), С. 448 - 448
Опубликована: Фев. 2, 2018
Apoptosis,
the
cell’s
natural
mechanism
for
death,
is
a
promising
target
anticancer
therapy.
Both
intrinsic
and
extrinsic
pathways
use
caspases
to
carry
out
apoptosis
through
cleavage
of
hundreds
proteins.
In
cancer,
apoptotic
pathway
typically
inhibited
wide
variety
means
including
overexpression
antiapoptotic
proteins
under-expression
proapoptotic
Many
these
changes
cause
resistance
most
common
therapy,
chemotherapy.
Promising
new
therapies
are
plant-derived
compounds
that
exhibit
activity
activating
pathway.
Cold Spring Harbor Perspectives in Medicine,
Год журнала:
2015,
Номер
5(4), С. a006098 - a006098
Опубликована: Апрель 1, 2015
Richard
Sever1
and
Joan
S.
Brugge2
1Cold
Spring
Harbor
Laboratory,
Cold
Harbor,
New
York
11724
2Harvard
Medical
School,
Department
of
Cell
Biology,
Boston,
Massachusetts
02115
Correspondence:
joan_brugge{at}hms.harvard.edu
International Journal of Molecular Sciences,
Год журнала:
2020,
Номер
21(7), С. 2346 - 2346
Опубликована: Март 28, 2020
MAPK
(mitogen-activated
protein
kinase)
signaling
pathways
regulate
a
variety
of
biological
processes
through
multiple
cellular
mechanisms.
In
most
these
processes,
such
as
apoptosis,
MAPKs
have
dual
role
since
they
can
act
activators
or
inhibitors,
depending
on
the
cell
type
and
stimulus.
this
review,
we
present
main
pro-
anti-apoptotic
mechanisms
regulated
by
MAPKs,
well
crosstalk
observed
between
some
MAPKs.
We
also
describe
basic
properties
(ultrasensitivity,
hysteresis,
digital
response),
presence
different
positive
feedback
loops
in
apoptosis.
provide
simple
guide
to
predict
MAPKs’
behavior,
based
intensity
duration
Finally,
consider
osmostress-induced
apoptosis
using
Xenopus
oocytes
model.
As
will
see,
is
plagued
with
loops.
hope
review
help
understand
how
engage
irreversible
decisions.
