Targeting apoptosis in cancer therapy

Nature Reviews Clinical Oncology, Год журнала: 2020, Номер 17(7), С. 395 - 417

Опубликована: Март 23, 2020

Язык: Английский

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Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis

Genes & Diseases, Год журнала: 2018, Номер 5(2), С. 77 - 106

Опубликована: Май 12, 2018

As the most commonly occurring cancer in women worldwide, breast poses a formidable public health challenge on global scale. Breast consists of group biologically and molecularly heterogeneous diseases originated from breast. While risk factors associated with this varies respect to other cancers, genetic predisposition, notably mutations

Язык: Английский

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Cell Death Signaling

Cold Spring Harbor Perspectives in Biology, Год журнала: 2015, Номер 7(12), С. a006080 - a006080

Опубликована: Дек. 1, 2015

Douglas R. Green and Fabien Llambi Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105 Correspondence: douglas.green{at}stjude.org

Язык: Английский

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Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy

Seminars in Cancer Biology, Год журнала: 2019, Номер 80, С. 1 - 17

Опубликована: Дек. 19, 2019

Язык: Английский

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The lingering mysteries of metastatic recurrence in breast cancer

British Journal of Cancer, Год журнала: 2020, Номер 124(1), С. 13 - 26

Опубликована: Ноя. 26, 2020

Despite being the hallmark of cancer that is responsible for highest number deaths, very little known about biology metastasis. Metastatic disease typically manifests after a protracted period undetectable following surgery or systemic therapy, owing to relapse recurrence. In case breast cancer, metastatic can occur months decades initial diagnosis and treatment. this review, we provide an overview key factors influence recurrence, with goal highlighting critical unanswered questions still need be addressed make difference in mortality patients.

Язык: Английский

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Signaling Networks that Regulate Cell Migration

Cold Spring Harbor Perspectives in Biology, Год журнала: 2015, Номер 7(8), С. a005959 - a005959

Опубликована: Авг. 1, 2015

Stimuli that promote cell migration, such as chemokines, cytokines, and growth factors in metazoans cyclic AMP Dictyostelium, activate signaling pathways control organization of the actin cytoskeleton adhesion complexes. The Rho-family GTPases are a key convergence point these pathways. Their effectors include regulators formins, members WASP/WAVE family Arp2/3 complex, myosin II motor protein. Pathways link to Rho Ras GTPases, TorC2, PI3K. Many molecules involved form gradients within cells, which define front rear migrating also established related cellular behaviors neuronal cone extension cytokinesis. regulate migration can be integrated provide model network function. displays biochemical excitability seen spontaneous waves activation propagate along cortex. These events coordinate movement biased by external cues bring about directed migration.

Язык: Английский

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Liquid–liquid phase separation drives cellular function and dysfunction in cancer

Nature reviews. Cancer, Год журнала: 2022, Номер 22(4), С. 239 - 252

Опубликована: Фев. 11, 2022

Язык: Английский

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Biomolecular Condensates and Cancer

Cancer Cell, Год журнала: 2021, Номер 39(2), С. 174 - 192

Опубликована: Янв. 9, 2021

Язык: Английский

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Natural products: An upcoming therapeutic approach to cancer

Food and Chemical Toxicology, Год журнала: 2019, Номер 128, С. 240 - 255

Опубликована: Апрель 13, 2019

Язык: Английский

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Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 150, С. 113054 - 113054

Опубликована: Апрель 30, 2022

Cancer is one of the leading causes death and significantly burdens healthcare system. Due to its prevalence, there undoubtedly an unmet need discover novel anticancer drugs. The use natural products as agents acceptable therapeutic approach due accessibility, applicability, reduced cytotoxicity. Natural have been incomparable source drugs in modern era drug discovery. Along with their derivatives analogs, play a major role cancer treatment by modulating microenvironment different signaling pathways. These compounds are effective against several pathways, mainly cell pathways (apoptosis autophagy) embryonic developmental (Notch pathway, Wnt Hedgehog pathway). historical record strong, but investigate current discovery development determine possibility being important future agents. Many target-specific failed provide successful results, which accounts for multi-target characteristics achieve better outcomes. potential be promising makes them area research. This review explores significance inhibiting various that serve drivers carcinogenesis thus pave way developing discovering

Язык: Английский

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