Regulated cell death (RCD) in cancer: key pathways and targeted therapies

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Авг. 13, 2022

Regulated cell death (RCD), also well-known as programmed (PCD), refers to the form of that can be regulated by a variety biomacromolecules, which is distinctive from accidental (ACD). Accumulating evidence has revealed RCD subroutines are key features tumorigenesis, may ultimately lead establishment different potential therapeutic strategies. Hitherto, targeting with pharmacological small-molecule compounds been emerging promising avenue, rapidly progressed in many types human cancers. Thus, this review, we focus on summarizing not only apoptotic and autophagy-dependent signaling pathways, but crucial pathways other subroutines, including necroptosis, pyroptosis, ferroptosis, parthanatos, entosis, NETosis lysosome-dependent (LCD) cancer. Moreover, further discuss current situation several improve cancer treatment, such single-target, dual or multiple-target compounds, drug combinations, some new strategies would together shed light future directions attack vulnerabilities drugs for purposes.

Язык: Английский

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Cellular aging beyond cellular senescence: Markers of senescence prior to cell cycle arrest in vitro and in vivo

Aging Cell, Год журнала: 2021, Номер 20(4)

Опубликована: Март 12, 2021

Abstract The field of research on cellular senescence experienced a rapid expansion from being primarily focused in vitro aspects aging to the vast territories animal and clinical research. Cellular is defined by set markers, many which are present accumulate gradual manner prior induction or found outside context senescence. These markers now used measure impact disease as well outcomes anti‐senescence interventions, at stage trials. It thus primary importance discuss their specificity role establishment Here, presence described cells cell cycle arrest, especially replicative vivo conditions. Specifically, this review article seeks describe process “cellular aging”: progression internal changes occurring leading culminating death. Phenotypic associated with will be characterized, effect final fate reviewed. Using published datasets assessments , it how disparities between quantifications can explained concept aging. Finally, throughout applicational value broadening paradigm discussed.

Язык: Английский

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MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma

Cancers, Год журнала: 2021, Номер 13(12), С. 3026 - 3026

Опубликована: Июнь 17, 2021

Hepatocellular carcinoma (HCC) is a major health concern worldwide, and its incidence increasing steadily. Recently, the MAPK/ERK signaling pathway in HCC has gained renewed attention from basic clinical researchers. The activated more than 50% of human cases; however, activating mutations RAS RAF genes are rarely found HCC, which genetic events leading to activation other cancers. This suggests that there an alternative mechanism behind HCC. Here, we will review recent advances understanding cellular molecular mechanisms involved discuss potential therapeutic strategies targeting context

Язык: Английский

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The signaling pathways and targets of traditional Chinese medicine and natural medicine in triple-negative breast cancer

Journal of Ethnopharmacology, Год журнала: 2020, Номер 264, С. 113249 - 113249

Опубликована: Авг. 15, 2020

Язык: Английский

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The role of oxidative stress in ovarian aging: a review

Journal of Ovarian Research, Год журнала: 2022, Номер 15(1)

Опубликована: Сен. 1, 2022

Abstract Ovarian aging refers to the process by which ovarian function declines until eventual failure. The pathogenesis of is complex and diverse; oxidative stress (OS) considered be a key factor. This review focuses on fact that OS status accelerates promoting apoptosis, inflammation, mitochondrial damage, telomere shortening biomacromolecular damage. Current evidence suggests aging, smoking, high-sugar diets, pressure, superovulation, chemotherapeutic agents industrial pollutants can factors accelerate exacerbating status. In addition, we role nuclear factor E2-related 2 (Nrf2), Sirtuin (Sirt), mitogen-activated protein kinase (MAPK), B (AKT), Forkhead box O (FoxO) Klotho signaling pathways during aging. We also explore antioxidant therapies such as melatonin, vitamins, stem cell therapies, monomers Traditional Chinese Medicine (TCM), investigate roles these supplements with respect reduction improvement function. provides rationale for therapy improve

Язык: Английский

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Apoptosis in Alzheimer’s disease: insight into the signaling pathways and therapeutic avenues

APOPTOSIS, Год журнала: 2023, Номер 28(7-8), С. 943 - 957

Опубликована: Апрель 26, 2023

Язык: Английский

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Anticancer Activity of Propolis and Its Compounds

Nutrients, Год журнала: 2021, Номер 13(8), С. 2594 - 2594

Опубликована: Июль 28, 2021

Propolis is a natural material that honey bees (Apis mellifera) produce from various botanical sources. The therapeutic activity of propolis, including antibacterial, antifungal, and anti-inflammatory effects, have been known since antiquity. Cancer one the major burdens disease worldwide, therefore, numerous studies are being conducted to develop new chemotherapeutic agents treatments for cancer. rich source biologically active compounds, which affect signaling pathways regulating crucial cellular processes. results latest research show propolis can inhibit proliferation, angiogenesis, metastasis cancer cells stimulate apoptosis. Moreover, it may influence tumor microenvironment multidrug resistance cancers. This review briefly summarizes molecular mechanisms anticancer its compounds highlights potential benefits reduce side effects chemotherapy radiotherapy.

Язык: Английский

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Highly Retina-Permeating and Long-Acting Resveratrol/Metformin Nanotherapeutics for Enhanced Treatment of Macular Degeneration

ACS Nano, Год журнала: 2022, Номер 17(1), С. 168 - 183

Опубликована: Дек. 16, 2022

The development of therapeutics for effective treatments retinal diseases is significantly constrained by various biological barriers. We herein report a nanomedicine strategy to develop nanotherapeutics featured with not only high permeability but also sustained bioactive delivery. Specifically, the are rationally designed via aminolysis resveratrol-encapsulated polycaprolactone nanoparticles (R@PCL NPs), followed formation amide linkages carboxyl-terminated transacting activator transcription cell penetrating peptide (T) and metformin (M). R@PCL-T/M NP demonstrated in vitro possess persistent drug release profiles, good ocular biocompatibility, potent activities targeting prevailing risk factors associated diseases. In vivo studies indicate that single-dose intravitreal administration NPs can effectively improve (∼15-fold increase), prevent loss endogenous antioxidants, suppress growth abnormal vessels retina macular degeneration 56 days. This treatment efficacy be ascribed enhanced conjunction pharmacological activity dual drugs (R M) pigment epithelial region. These findings show great promise nanoformulations capable thereby treating complex posterior segment improved efficacies.

Язык: Английский

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E3 ligases and deubiquitinating enzymes regulating the MAPK signaling pathway in cancers

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2022, Номер 1877(3), С. 188736 - 188736

Опубликована: Май 1, 2022

Язык: Английский

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Oxidative stress in intervertebral disc degeneration: Molecular mechanisms, pathogenesis and treatment

Cell Proliferation, Год журнала: 2023, Номер 56(9)

Опубликована: Март 13, 2023

Abstract Low back pain (LBP) is a leading cause of labour loss and disability worldwide, it also imposes severe economic burden on patients society. Among symptomatic LBP, approximately 40% caused by intervertebral disc degeneration (IDD). IDD the pathological basis many spinal degenerative diseases such as herniation stenosis. Currently, therapeutic approaches for mainly include conservative treatment surgical treatment, neither which can solve problem from root terminating process (IVD). Therefore, further exploring pathogenic mechanisms adopting targeted strategies one current research hotspots. complex pathophysiological processes IDD, oxidative stress considered main factor. The delicate balance between reactive oxygen species (ROS) antioxidants essential maintaining normal function survival IVD cells. Excessive ROS levels damage to macromolecules nucleic acids, lipids, proteins cells, affect cellular activities functions, ultimately lead cell senescence or death. This review discusses potential role in understand provides IDD.

Язык: Английский

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