Proceedings of the National Academy of Sciences,
Год журнала:
2022,
Номер
119(32)
Опубликована: Авг. 5, 2022
Animal
tissues
comprise
diverse
cell
types.
However,
the
mechanisms
controlling
number
of
each
type
within
tissue
compartments
remain
poorly
understood.
Here,
we
report
that
different
types
utilize
distinct
strategies
to
control
population
numbers.
Proliferation
fibroblasts,
stromal
cells
important
for
integrity,
is
limited
by
space
availability.
In
contrast,
proliferation
macrophages,
innate
immune
involved
in
defense,
repair,
and
homeostasis,
constrained
growth
factor
Examination
density-dependent
gene
expression
fibroblasts
revealed
Hippo
TGF-β
target
genes
are
both
regulated
density.
We
found
YAP1,
transcriptional
coactivator
signaling
pathway,
directly
regulates
Csf1
,
lineage-specific
through
an
enhancer
specifically
active
fibroblasts.
Activation
YAP1
elevates
sufficient
increase
macrophages
at
steady
state.
Our
data
also
suggest
programs
change
with
density
may
result
from
sensing
mechanical
force
actin-dependent
mechanisms.
Altogether,
demonstrate
two
modes
connected
coordinated
regulate
numbers
Sensing
environment
serve
as
a
general
strategy
composition.
Cold Spring Harbor Perspectives in Biology,
Год журнала:
2015,
Номер
7(4), С. a005934 - a005934
Опубликована: Апрель 1, 2015
Evren
U.
Azeloglu
and
Ravi
Iyengar
Department
of
Pharmacology
Systems
Therapeutics
Biology
Center
New
York,
Mount
Sinai
School
Medicine,
York
10029
Correspondence:
ravi.iyengar{at}mssm.edu
Cold Spring Harbor Perspectives in Biology,
Год журнала:
2016,
Номер
8(6), С. a005918 - a005918
Опубликована: Июнь 1, 2016
Michael
J.
Lee
and
B.
Yaffe
David
H.
Koch
Institute
for
Integrative
Cancer
Research
at
MIT,
Department
of
Biology
Biological
Engineering,
Massachusetts
Technology,
Cambridge,
02139
Correspondence:
myaffe{at}mit.edu
Successful
cell
proliferation
requires
efficient
and
precise
genome
duplication
followed
by
accurate
chromosome
segregation.
The
Cdc10-dependent
transcript
1
protein
(Cdt1)
is
required
for
the
first
step
in
DNA
replication,
human
cells
Cdt1
also
during
mitosis.
Tight
cycle
controls
over
abundance
activity
are
critical
to
normal
development
stability.
We
review
here
recent
advances
elucidating
molecular
functions
both
origin
licensing
kinetochore–microtubule
attachment,
we
describe
current
understanding
of
regulation.
Marine Drugs,
Год журнала:
2015,
Номер
13(8), С. 4784 - 4798
Опубликована: Июль 31, 2015
Fucoxanthin
is
a
carotenoid
present
in
the
chloroplasts
of
brown
seaweeds.
When
ingested,
it
metabolized
mainly
to
fucoxanthinol
by
digestive
enzymes
gastrointestinal
tract.
These
compounds
have
been
shown
many
beneficial
health
effects,
including
anti-mutagenic,
anti-diabetic,
anti-obesity,
anti-inflammatory
and
anti-neoplastic
actions.
In
every
cancer
tested,
modulatory
actions
on
viability,
cell-cycle
arrest,
apoptosis
members
NF-κB
pathway
were
more
pronounced
than
that
fucoxanthin.
Anti-proliferative
preventing
influences
fucoxanthin
are
mediated
through
different
signalling
pathways,
caspases,
Bcl-2
proteins,
MAPK,
PI3K/Akt,
JAK/STAT,
AP-1,
GADD45,
several
other
molecules
involved
cell
cycle
apoptosis,
anti-angiogenesis
or
inhibition
metastasis.
this
review,
we
address
mechanisms
action
according
types
cancers.
Current
findings
suggest
these
could
be
effective
for
treatment
and/or
prevention
development
aggressiveness.
PLoS Biology,
Год журнала:
2019,
Номер
17(4), С. e3000228 - e3000228
Опубликована: Апрель 30, 2019
Circadian
disruption
has
multiple
pathological
consequences,
but
the
underlying
mechanisms
are
largely
unknown.
To
address
such
mechanisms,
we
subjected
transformed
cultured
cells
to
chronic
circadian
desynchrony
(CCD),
mimicking
a
jet-lag
scheme,
and
assayed
range
of
cellular
functions.
The
results
indicated
specific
clock–dependent
increase
in
cell
proliferation.
Transcriptome
analysis
revealed
up-regulation
G1/S
phase
transition
genes
(myelocytomatosis
oncogene
homolog
[Myc],
cyclin
D1/3,
chromatin
licensing
DNA
replication
factor
1
[Cdt1]),
concomitant
with
increased
phosphorylation
retinoblastoma
(RB)
protein
by
cyclin-dependent
kinase
(CDK)
4/6
G1-S
progression.
Phospho-RB
(Ser807/811)
was
found
oscillate
fashion
exhibit
phase-shifted
rhythms
desynchronized
cells.
Consistent
regulation,
CDK4/6
inhibitor
approved
for
cancer
treatment
reduced
growth
mouse
tumors
time-of-day–specific
manner.
Our
study
identifies
mechanism
that
underlies
effects
on
tumor
underscores
use
timed
endogenous
rhythms.
Frontiers in Oncology,
Год журнала:
2020,
Номер
10
Опубликована: Ноя. 30, 2020
Cell
cycle
is
regulated
by
a
number
of
proteins
namely
cyclin-dependent
kinases
(CDKs)
and
their
associated
cyclins
which
bind
with
activate
CDKs
in
phase
specific
manner.
Additionally,
several
transcription
factors
(TFs)
such
as
E2F
p53
numerous
signaling
pathways
regulate
cell
progression.
Recent
studies
have
accentuated
the
role
long
non-coding
RNAs
(lncRNAs)
microRNAs
(miRNAs)
regulation
cycle.
Both
lncRNAs
miRNAs
interact
TFs
participating
transition.
Dysregulation
regulatory
results
human
disorders
particularly
cancers.
Understanding
lncRNAs,
miRNAs,
would
pave
way
for
design
anticancer
therapies
intervene
In
current
review,
we
describe
association
malignancies.
