Biomolecules,
Год журнала:
2022,
Номер
12(3), С. 367 - 367
Опубликована: Фев. 25, 2022
Cancer
is
a
complex
disease
resulting
from
the
genetic
and
epigenetic
disruption
of
normal
cells.
The
mechanistic
understanding
pathways
involved
in
tumor
transformation
has
implicated
priori
predominance
perturbations
posteriori
instability.
In
this
work,
we
aimed
to
explain
involvement
cancer
process,
as
well
abilities
natural
bioactive
compounds
isolated
medicinal
plants
(flavonoids,
phenolic
acids,
stilbenes,
ketones)
specifically
target
epigenome
molecular
events
leading
transformation,
angiogenesis,
dissemination
are
often
complex,
stochastic,
take
turns.
On
other
hand,
decisive
advances
genomics,
epigenomics,
transcriptomics,
proteomics
have
allowed,
recent
years,
for
decryption
cancerization
process.
This
could
possibility
targeting
or
that
mechanism
cancerization.
With
plasticity
flexibility
modifications,
some
studies
started
pharmacological
screening
substances
against
different
(DNA
methylation,
histone
acetylation,
chromatin
remodeling)
restore
cellular
memory
lost
during
transformation.
These
can
inhibit
DNMTs,
modify
remodeling,
adjust
modifications
favor
pre-established
cell
identity
by
differentiation
program.
Epidrugs
molecules
program
therefore
cancerous
diseases.
Natural
products
such
flavonoids
acids
shown
their
ability
exhibit
several
actions
on
modifiers,
inhibition
DNMT,
HMT,
HAT.
mechanisms
these
specific
pleiotropic
sometimes
be
use
anticancer
epidrugs
currently
remarkable
avenue
fight
human
cancers.
Cold Spring Harbor Perspectives in Biology,
Год журнала:
2014,
Номер
6(4), С. a018713 - a018713
Опубликована: Апрель 1, 2014
Edward
Seto1
and
Minoru
Yoshida2
1Department
of
Molecular
Oncology,
Moffitt
Cancer
Center
Research
Institute,
Tampa,
Florida
33612
2Chemical
Genetics
Laboratory,
RIKEN,
Wako,
Saitama
351-0198,
Japan
Correspondence:
ed.seto{at}moffitt.org
Cold Spring Harbor Perspectives in Biology,
Год журнала:
2016,
Номер
8(9), С. a019505 - a019505
Опубликована: Май 18, 2016
Stephen
B.
Baylin1
and
Peter
A.
Jones2
1Cancer
Biology
Program,
Johns
Hopkins
University,
School
of
Medicine,
Baltimore,
Maryland
21287
2Van
Andel
Research
Institute,
Grand
Rapids,
Michigan
49503
Correspondence:
sbaylin{at}jhmi.edu
Signal Transduction and Targeted Therapy,
Год журнала:
2019,
Номер
4(1)
Опубликована: Дек. 17, 2019
Epigenetic
alternations
concern
heritable
yet
reversible
changes
in
histone
or
DNA
modifications
that
regulate
gene
activity
beyond
the
underlying
sequence.
dysregulation
is
often
linked
to
human
disease,
notably
cancer.
With
development
of
various
drugs
targeting
epigenetic
regulators,
epigenetic-targeted
therapy
has
been
applied
treatment
hematological
malignancies
and
exhibited
viable
therapeutic
potential
for
solid
tumors
preclinical
clinical
trials.
In
this
review,
we
summarize
aberrant
functions
enzymes
methylation,
acetylation
methylation
during
tumor
progression
highlight
inhibitors
targeted
at
enzymes.
Cold Spring Harbor Perspectives in Biology,
Год журнала:
2016,
Номер
8(4), С. a019521 - a019521
Опубликована: Апрель 1, 2016
Histone
posttranslational
modifications
represent
a
versatile
set
of
epigenetic
marks
involved
not
only
in
dynamic
cellular
processes,
such
as
transcription
and
DNA
repair,
but
also
the
stable
maintenance
repressive
chromatin.
In
this
article,
we
review
many
key
newly
identified
histone
known
to
be
deregulated
cancer
how
impacts
function.
The
latter
part
article
addresses
challenges
current
status
drug
development
process
it
applies
therapeutics.
Abstract
The
epigenetic
modifications
of
histones
are
versatile
marks
that
intimately
connected
to
development
and
disease
pathogenesis
including
human
cancers.
In
this
review,
we
will
discuss
the
many
different
types
histone
biological
processes
with
which
they
involved.
Specifically,
review
enzymatic
machineries
involved
in
cancer
progression,
how
apply
currently
available
small
molecule
inhibitors
for
modifiers
as
tool
compounds
study
functional
significance
their
clinical
implications.
Cold Spring Harbor Perspectives in Biology,
Год журнала:
2014,
Номер
6(12), С. a019315 - a019315
Опубликована: Дек. 1, 2014
Craig
S.
Pikaard1
and
Ortrun
Mittelsten
Scheid2
1Department
of
Biology,
Department
Molecular
Cellular
Biochemistry,
Howard
Hughes
Medical
Institute,
Indiana
University,
Bloomington,
47405
2Gregor
Mendel-Institute
Plant
Austrian
Academy
Sciences,
1030
Vienna,
Austria
Correspondence:
ortrun.mittelsten_scheid{at}gmi.oeaw.ac.at
