Journal of Insect Physiology, Год журнала: 2019, Номер 116, С. 1 - 9
Опубликована: Апрель 3, 2019
Язык: Английский
Developmental Cell, Год журнала: 2019, Номер 49(1), С. 48 - 62.e3
Опубликована: Март 21, 2019
Язык: Английский
Процитировано
62
Current Biology, Год журнала: 2020, Номер 30(11), С. 2156 - 2165.e5
Опубликована: Май 7, 2020
Steroid hormones play key roles in development, growth, and reproduction various animal phyla [1Miller W.L. Auchus R.J. The molecular biology, biochemistry, physiology of human steroidogenesis its disorders.Endocr. Rev. 2011; 32: 81-151Crossref PubMed Scopus (1369) Google Scholar]. insect steroid hormone, ecdysteroid, coordinates growth maturation, represented by molting metamorphosis [2Niwa R. Niwa Y.S. Enzymes for ecdysteroid biosynthesis: their biological functions insects beyond.Biosci. Biotechnol. Biochem. 2014; 78: 1283-1292Crossref (148) In Drosophila melanogaster, the prothoracicotropic hormone (PTTH)-producing neurons stimulate peak levels biosynthesis maturation [3McBrayer Z. Ono H. Shimell M. Parvy J.-P. Beckstead R.B. Warren J.T. Thummel C.S. Dauphin-Villemant C. Gilbert L.I. O'Connor M.B. Prothoracicotropic regulates developmental timing body size Drosophila.Dev. Cell. 2007; 13: 857-871Abstract Full Text PDF (316) Additionally, recent studies on PTTH signaling indicated that basal negatively affect systemic prior to [4Colombani J. Bianchini L. Layalle S. Pondeville E. Antoniewski Carré Noselli Léopold P. Antagonistic actions ecdysone insulins determine final Drosophila.Science. 2005; 310: 667-670Crossref (464) Scholar, 5Delanoue Slaidina controls repressing dMyc function fat cells.Dev. 2010; 18: 1012-1021Abstract (134) 6Boulan Martín D. Milán bantam miRNA promotes connecting insulin production.Curr. Biol. 2013; 23: 473-478Abstract (68) 7Boulan control growth.Cold Spring Harb. Perspect. 2015; 7: a019117PubMed 8Moeller M.E. Nagy Gerlach S.U. Soegaard K.C. Danielsen E.T. Texada M.J. Rewitz K.F. Warts organ through regulation ecdysone.Curr. 2017; 27: 1652-1659.e4Abstract (31) However, it remains unclear how is regulated biosynthesis. Here, we report Corazonin (Crz)-producing regulate affecting neurons. Crz belongs gonadotropin-releasing (GnRH) superfamily, implying an analogous role [9Zandawala Tian Elphick M.R. evolution nomenclature GnRH-type corazonin-type neuropeptide systems.Gen. Comp. Endocrinol. 2018; 264: 64-77Crossref (59) Inhibition neuronal activity increased pupal size, whereas hardly affected pupariation timing. This phenotype resulted from enhanced rate a delay elevation during mid-third instar larval (L3) stage. Interestingly, receptor (CrzR) expression was higher mid- than late-L3 Silencing CrzR phenocopying inhibition activity. When were optogenetically activated, strong calcium response observed mid-L3, but not late-L3, Furthermore, found octopamine contact subesophageal zone (SEZ), transmitting signals growth. Together, our results suggest Crz-PTTH axis modulates octopamine, uncovering regulatory neuroendocrine system transition maturation.
Язык: Английский
Процитировано
60
Nature Communications, Год журнала: 2019, Номер 10(1)
Опубликована: Апрель 26, 2019
Abstract Organisms adapt their metabolism and growth to the availability of nutrients oxygen, which are essential for development, yet mechanisms by this adaptation occurs not fully understood. Here we describe an RNAi-based body-size screen in Drosophila identify such mechanisms. Among strongest hits is fibroblast factor receptor homolog breathless necessary proper development tracheal airway system. Breathless deficiency results tissue hypoxia, sensed primarily context fat through HIF-1a prolyl hydroxylase (Hph). The relays its hypoxic status release one or more HIF-1a-dependent humoral factors that inhibit insulin secretion from brain, thereby restricting systemic growth. Independently HIF-1a, Hph also required nutrient-dependent Target-of-rapamycin (Tor) activation. Our findings show acts as primary sensor nutrient oxygen levels, directing organismal environmental conditions.
Язык: Английский
Процитировано
59
Proceedings of the National Academy of Sciences, Год журнала: 2020, Номер 117(17), С. 9292 - 9301
Опубликована: Апрель 10, 2020
Significance Final body size determination in animals remains a long-standing puzzle the field of developmental biology. In insects, insulin/insulin-like growth factor signaling (IIS) and steroid hormone 20-hydroxyecdysone (20E) are mainly responsible for rate period, respectively, consequently final size. Here, we report that 20E activates AMPK by up-regulating its gene expression inducing sugar starvation. turn, protein phosphatase 2A, which further dephosphorylates inactivates key components IIS fat body, eventually suppresses larval rate. These data answer question how antagonizes modulates
Язык: Английский
Процитировано
58
Nature, Год журнала: 2024, Номер 630(8016), С. 392 - 400
Опубликована: Май 29, 2024
Abstract Organs have a distinctive yet often overlooked spatial arrangement in the body 1–5 . We propose that there is logic to shape of an organ and its proximity neighbours. Here, by using volumetric scans many Drosophila melanogaster flies, we develop methods quantify three-dimensional features shape, position interindividual variability. find both shapes organs their relative are consistent differ between sexes, identify unexpected interorgan adjacencies left–right asymmetries. Focusing on intestine, which traverses entire body, investigate how sex differences geometry arise. The configuration adult intestine only partially determined physical constraints imposed adjacent organs; sex-specific actively maintained mechanochemical crosstalk gut muscles vascular-like trachea. Indeed, sex-biased expression muscle-derived fibroblast growth factor-like ligand renders trachea sexually dimorphic. In turn, tracheal branches hold loops together into male or female with physiological consequences. Interorgan represents previously unrecognized level biological complexity might enable confine communication across could help explain species function.
Язык: Английский
Процитировано
6
The Journal of Immunology, Год журнала: 2019, Номер 202(9), С. 2747 - 2759
Опубликована: Март 22, 2019
Immune and metabolic pathways collectively influence host responses to microbial invaders, mutations in one pathway frequently disrupt activity another. We used the Drosophila melanogaster model characterize homeostasis flies with modified immune deficiency (IMD) activity. The IMD is very similar mammalian TNF-α pathway, a key regulator of vertebrate immunity metabolism. found that persistent activation resulted hyperglycemia, depleted fat reserves, developmental delays, implicating regulation. Consistent this hypothesis, we imd mutants weigh more, are hyperlipidemic, have impaired glucose tolerance. To test importance regulation for bacterial infection, challenged insulin lethal doses several pathogens. loss-of-function impacted infection manner depends on route identity infectious microbe. Combined, our results support role coordinated containment invaders.
Язык: Английский
Процитировано
53
Current Biology, Год журнала: 2017, Номер 27(11), С. 1652 - 1659.e4
Опубликована: Май 18, 2017
Язык: Английский
Процитировано
50
BioEssays, Год журнала: 2020, Номер 42(8)
Опубликована: Июнь 30, 2020
Abstract Large‐scale patterns of correlated growth in development are partially driven by competition for metabolic and informational resources. It is argued that between organs limited resources an important mesoscale morphogenetic mechanism produces fitness‐enhancing growth. At the genetic level, individual characters appears independent, or “modular,” because expression transcription often highly localized, mutations have trait‐specific effects, gene complexes can be co‐opted as a unit to produce novel traits. However, body parts known interact over course ontogeny, these reciprocal exchanges determinant developmental outcomes. Genetic mechanisms underlie cell tissue behaviors allow communicate with one another, but they also create evolutionarily adaptive competitive dynamics physiological biophysical processes. Advances understanding closely related coordinative interactions across scales will complement existing research programs emphasize role cellular morphogenesis. Study large‐scale order produced promises facilitate advances basic evolutionary biology, well applied fields such bioengineering regenerative medicine aim regulate patterning
Язык: Английский
Процитировано
46
Developmental & Comparative Immunology, Год журнала: 2019, Номер 94, С. 22 - 34
Опубликована: Янв. 24, 2019
Язык: Английский
Процитировано
44
eLife, Год журнала: 2021, Номер 10
Опубликована: Янв. 15, 2021
Nutrient-dependent body size plasticity differs between the sexes in most species, including mammals. Previous work Drosophila showed that was higher females, yet mechanisms underlying increased female remain unclear. Here, we discover a protein-rich diet augments females and not males because of female-biased increase activity conserved insulin/insulin-like growth factor signaling pathway (IIS). This sex-biased upregulation IIS triggered by diet-induced stunted mRNA required insulin-like peptide 2 , illuminating new sex-specific roles for these genes. Importantly, show sex determination gene transformer promotes via transcriptional coactivator Spargel to regulate male-female difference plasticity. Together, findings provide vital insight into nutrient-dependent
Язык: Английский
Процитировано
41