Medical Oncology, Год журнала: 2022, Номер 40(1)
Опубликована: Окт. 29, 2022
Язык: Английский
Learning & Memory, Год журнала: 2015, Номер 22(9), С. 426 - 437
Опубликована: Авг. 18, 2015
Circadian clocks evolved under conditions of environmental variation, primarily alternating light dark cycles, to enable organisms anticipate daily events and coordinate metabolic, physiological, behavioral activities. However, modern lifestyle advances in technology have increased the percentage individuals working phases misaligned with natural circadian activity rhythms. Endogenous oscillators modulate alertness, acquisition learning, memory formation, recall examples modulation observed across phyla from invertebrates humans. Cognitive performance are significantly diminished when occurring out phase Disruptions regulation can lead impairment formation memories manifestation other cognitive deficits. This review explores types interactions through which clock modulates cognition, highlights recent progress identifying mechanistic between system processes involved outlines methods used remediate perturbations reinforce adaptation.
Язык: Английский
Процитировано
89
Cold Spring Harbor Perspectives in Biology, Год журнала: 2015, Номер 7(5), С. a021675 - a021675
Опубликована: Фев. 26, 2015
John H. Byrne1 and Robert D. Hawkins2,3 1Department of Neurobiology Anatomy, The University Texas Medical School at Houston, 77030 2Department Neuroscience, Columbia University, New York, York 10032 3New State Psychiatric Institute, Correspondence: john.h.byrne{at}uth.tmc.edu
Язык: Английский
Процитировано
82
Frontiers in Genetics, Год журнала: 2016, Номер 7
Опубликована: Май 3, 2016
The dynamic composition of proteins associated with nuclear DNA is a fundamental property chromosome biology. In the chromatin compartment dedicated protein complexes govern accurate synthesis and repair genomic information define state compaction in vital cellular processes such as segregation or transcription. Unscheduled faulty association has detrimental consequences on genome integrity. Consequently, organization chromatin-bound remarkably can respond rapidly to signaling events, which requires tight spatiotemporal control. this context, ring-like AAA+ ATPase CDC48/p97 emerges key regulator that are marked ubiquitin SUMO. Mechanistically, functions segregase facilitating extraction substrate from chromatin. As such, drives molecular reactions either by directed disassembly rearrangement complexes. importance mechanism reflected human pathologies linked p97 mutations, including neurodegenerative disorders, oncogenesis, premature aging. This review focuses recent insights into mechanisms determine function environment, particularly relevant for cancer aging research.
Язык: Английский
Процитировано
81
Nucleic Acids Research, Год журнала: 2017, Номер 45(19), С. 11159 - 11173
Опубликована: Авг. 14, 2017
Regions of highly repetitive DNA, such as those found in the nucleolus, show a self-organization that is marked by spatial segregation and frequent self-interaction. The mechanisms underlie sequestration these sub-domains are largely unknown. Using stochastic, bead-spring representation chromatin budding yeast, we find enrichment protein-mediated, dynamic chromosomal cross-links recapitulates segregation, morphology self-interaction nucleolus. Rates crosslinking have profound consequences on domain morphology. Our model demonstrates nucleolus phase separated from other nucleus predicts multiple rDNA loci will form single independent their location within genome. Fluorescent labeling yeast nucleoli with CDC14-GFP revealed split locus indeed forms We propose nuclear sub-domains, result separations nucleus, which driven crosslinks.
Язык: Английский
Процитировано
73
Earth-Science Reviews, Год журнала: 2019, Номер 201, С. 103065 - 103065
Опубликована: Дек. 19, 2019
Язык: Английский
Процитировано
72
Frontiers in Physiology, Год журнала: 2018, Номер 9
Опубликована: Авг. 3, 2018
Important insights into the selection pressures and core molecular modules contributing to evolution of pain-related processes have come from studies nociceptive systems in several molluscan arthropod species. These phyla, chordates that include humans, last shared a common ancestor approximately 550 million years ago. Since then, animals these phyla continued be subject traumatic injury, often predators, which has led similar adaptive behaviors (e.g., withdrawal, escape, recuperative behavior) physiological responses injury each group. Comparisons across taxa provide clues about contributions convergent conservation ancient mechanisms general functions. Primary nociceptors been investigated extensively few species, with long-lasting sensitization gastropod, Aplysia, insect, Drosophila, being especially fruitful. In as model for aversive memory hyperalgesia. Neuromodulator-induced, activity-dependent, axotomy-induced plasticity defined synapses, cell bodies, axons Aplysia primary nociceptors. Studies Drosophila larvae revealed numerous contributors interacting cells. Interestingly, examined thus far are largely different, but both sets overlap those mammalian pathways. contrast results moth (Manduca) disclosed central hyperactivity no obvious peripheral responses. Squid (Doryteuthis) show injury-induced manifested behavioral hypersensitivity tactile visual stimuli, spontaneous activity nociceptor terminals. Temporary blockade during subsequently increased mortality when injured squid were exposed fish providing first demonstration any animal adaptiveness sensitization. Immediate noxious stimulation also behaviorally physiologically snail (Helix), octopus (Adopus), crayfish (Astacus), hermit crab (Pagurus), shore (Hemigrapsus). Molluscs arthropods suppress responses, whether opioid play antinociceptive roles is uncertain.
Язык: Английский
Процитировано
71
Genes Brain & Behavior, Год журнала: 2016, Номер 16(1), С. 71 - 85
Опубликована: Июль 26, 2016
The mammalian forebrain is characterized by the presence of several parallel cortico‐basal ganglia circuits that shape learning and control actions. Among these are associative, limbic sensorimotor circuits. function all has now been implicated in responses to drugs abuse, as well drug seeking taking. While circuit most widely examined, key roles for other two goal‐directed habitual instrumental actions related abuse have shown. In this review we describe three effects acute chronic exposure on physiology. Our main emphasis dorsal striatal components associative We then findings taking behaviors, use disorders. Finally, consider different models describing how become involved drug‐related behaviors. This topic implications disorders addiction, treatments target balance between may be useful reducing excessive substance use.
Язык: Английский
Процитировано
69
Cell Death and Disease, Год журнала: 2020, Номер 11(9)
Опубликована: Сен. 17, 2020
Abstract Triple-negative breast cancer (TNBC), defined as loss of estrogen, progesterone, and Her2 receptors, is a subtype highly aggressive with worse prognosis poor survival rate. Macrophage migration inhibitory factor (MIF) pleiotropic pro-inflammatory cytokine aberrantly expressed in many solid tumors known to promote tumor progression metastasis. However, its role TNBC metastasis unexplored. Here we have shown that patients, MIF expression was significantly enriched the compared adjacent normal tissue. Using publically available patient datasets, showed overexpression correlates other hormonal status. Orthotopic implantation cells into knockout mice reduced growth wild-type mice. In addition, downregulation inhibits syngeneic mouse model. We further CPSI-1306, small-molecule inhibitor, vitro. Mechanistic studies revealed CPSI-1306 induces intrinsic apoptosis by alteration mitochondrial membrane potential, cytochrome c (Cyt ) release, activation different caspases. cell proliferation-related molecules. treatment also orthotopic models mammary carcinoma. tumor-bearing inhibited pulmonary dose-dependent manner. Histological analysis xenograft higher number apoptotic CPSI-1306-treated vehicle controls. Our studies, for first time, show enhances Taken together, our results indicate using small molecular weight inhibitors could be promising strategy inhibit
Язык: Английский
Процитировано
64
Sign Systems Studies, Год журнала: 2018, Номер 46(4), С. 452 - 466
Опубликована: Дек. 31, 2018
We examine the possibility of shifting concept choice to centre semiotic theory learning. Thus, we define sign process (meaning-making) through choice: semiosis is making choices between simultaneously provided options. learning as leaving traces by choices, while these influence further choices. term such memory. Further modification (constraints) will be called habituation. Organic needs are homeostatic mechanisms coupled with choice-making. Needs and habits result in motivatedness. Semiosis choice-making can seen a complementary description Peircean triadic model semiosis; however, this fit also models meaning-making worked out other shools semiotics. provide sketch for joint typology
Язык: Английский
Процитировано
62
Neuroscience & Biobehavioral Reviews, Год журнала: 2019, Номер 108, С. 602 - 616
Опубликована: Ноя. 28, 2019
Язык: Английский
Процитировано
62