Aquaculture, Год журнала: 2023, Номер 579, С. 740195 - 740195
Опубликована: Окт. 5, 2023
Язык: Английский
Cold Spring Harbor Perspectives in Biology, Год журнала: 2019, Номер 12(1), С. a038802 - a038802
Опубликована: Авг. 19, 2019
Martin D. Bootman1 and Geert Bultynck2 1School of Life, Health Chemical Sciences, The Open University, Milton Keynes MK7 6AA, United Kingdom 2Laboratory Molecular Cellular Signaling, Department Medicine, KU Leuven, B-3000 Belgium Correspondence: martin.bootman{at}open.ac.uk
Язык: Английский
Процитировано
228
Molecular Cell, Год журнала: 2020, Номер 78(6), С. 1055 - 1069
Опубликована: Июнь 1, 2020
Язык: Английский
Процитировано
187
Angewandte Chemie International Edition, Год журнала: 2020, Номер 59(41), С. 18042 - 18047
Опубликована: Июнь 27, 2020
Abstract Ca 2+ , a ubiquitous but nuanced modulator of cellular physiology, is meticulously controlled intracellularly. However, intracellular regulation, such as mitochondrial buffering capacity, can be disrupted by 1 O 2 . Thus, the overload, which recognized one important cell pro‐death factors, logically achieved synergism with exogenous delivery. Reported herein nanoscale covalent organic framework (NCOF)‐based nanoagent, namely CaCO 3 @COF‐BODIPY‐2I@GAG ( 4 ), embedded nanoparticle (NP) and surface‐decorated BODIPY‐2I photosensitizer (PS) glycosaminoglycan (GAG) targeting agent for CD44 receptors on digestive tract tumor cells. Under illumination, light‐triggered not only kills cells directly, also leads to their dysfunction overload. An enhanced antitumor efficiency via photodynamic therapy (PDT) overload synergistic therapy.
Язык: Английский
Процитировано
149
International Journal of Biological Sciences, Год журнала: 2021, Номер 17(8), С. 2034 - 2049
Опубликована: Янв. 1, 2021
The transient receptor potential cation channel subfamily V member 1 (TRPV1) is a transmembrane protein that can be activated by various physical and chemical stimuli associated with pain transduction.In recent years, TRPV1 was discovered to play essential roles in cancer tumorigenesis development, as expression levels are altered numerous cell types.Several investigations have direct associations between proliferation, death, metastasis.Furthermore, about two dozen agonists/antagonists under clinical trial, drug target for treating diseases.Hence, more researchers focusing on the effects of agonists or antagonists development.However, both may reveal anti-cancer effects, effect function via independent TRPV1.In this review, we provide an overview impact metastasis, well therapy tumor microenvironment, consider implications using future research therapeutic approaches.
Язык: Английский
Процитировано
104
Nature Reviews Urology, Год журнала: 2023, Номер 20(9), С. 524 - 543
Опубликована: Март 24, 2023
Язык: Английский
Процитировано
27
Archives of Biochemistry and Biophysics, Год журнала: 2025, Номер 769, С. 110440 - 110440
Опубликована: Апрель 25, 2025
Язык: Английский
Процитировано
1
International Journal of Biological Sciences, Год журнала: 2022, Номер 18(3), С. 1065 - 1078
Опубликована: Янв. 1, 2022
Intracellular calcium ions are key second messengers and play an important role in malignant transformation cancer progression.Estrogen can evoke intracellular increases through membrane-initiated effects activate subsequent kinase cascades within minutes normal cancerous epithelial cells.Ca 2+ -related proteins expressed cells or endometrial cells, some of which upregulated by estrogen.Both estrogen-induced transient long-term changes protein expression levels may be involved regulating initiation, progression metastasis.Calcium channel blockers reported to regulate both the rapid Ca increase cell proliferation, apoptosis migration, thus having potential for pharmacological modulators repurposed treatment cancer.
Язык: Английский
Процитировано
29
Frontiers in Oncology, Год журнала: 2021, Номер 11
Опубликована: Июнь 10, 2021
Breast cancer is one of the most frequent types worldwide and first cause cancer-related deaths in women. Although significant therapeutic advances have been achieved with drugs such as tamoxifen trastuzumab, breast still caused 627,000 2018. Since a multifactorial disease, it has become necessary to develop new molecular therapies that can target several relevant cellular processes at once. Ion channels are versatile regulators physiological- pathophysiological-related mechanisms, including cancer-relevant tumor progression, apoptosis inhibition, proliferation, migration, invasion, chemoresistance. main functions, conducting ions selectively through pore-forming structure located plasma membrane, protein–protein interactions their regulatory mechanisms. Among different ion channel families, Transient Receptor Potential (TRP) family stands out context since members proposed prognostic markers this pathology. However, only few approaches exist block specific activity during tumoral progress. In article, we describe TRP involved progress particular focus on binding partners also described drivers progression. Here, propose disrupting these attractive potential targets for treating neoplastic disease.
Язык: Английский
Процитировано
35
Molecular Oncology, Год журнала: 2022, Номер 17(5), С. 901 - 916
Опубликована: Дек. 10, 2022
The biological functions of short open reading frame (sORF)-encoded micropeptides remain largely unknown. Here, we report that LINC00998, a previously annotated lncRNA, was upregulated in multiple cancer types and the sORF on LINC00998 encoded micropeptide named SMIM30. SMIM30 localized membranes endoplasmic reticulum (ER) mitochondria. Silencing inhibited proliferation hepatoma cells vitro suppressed growth tumor xenografts N-nitrosodiethylamine-induced hepatoma. Overexpression 5'UTR-sORF sequence encoding wild-type SMIM30, enhanced cell growth, but this abolished when premature stop codon introduced into via single-base deletion. Gain- loss-of-function studies revealed peptide not reduced cytosolic calcium level, increased CDK4, cyclin E2, phosphorylated-Rb E2F1, promoted G1/S phase transition proliferation. effect silencing attenuated by chelator or agonist sarco/endoplasmic ATPase (SERCA) pump. These findings suggest novel function promoting enhancing SERCA activity reducing level.
Язык: Английский
Процитировано
21
International Journal of Oral Science, Год журнала: 2023, Номер 15(1)
Опубликована: Янв. 3, 2023
Abstract Tongue squamous cell carcinoma is highly malignant and has a poor prognosis. In this study, we aimed to combine whole-genome sequencing, methylation, whole-transcriptome analyses understand the molecular mechanisms of tongue better. Oral adjacent normal tissues from five patients with were included as paired samples. After multi-omics differentially methylated intervals, loop sites, promoters, transcripts screened for variation in all Correlations analyzed determine biological processes carcinoma. We found mutated methylation promoters that significantly associated mRNA lncRNA expression levels. Functional annotation these revealed their involvement triggering mitogen-activated protein kinase cascade, which cancer progression development drug resistance during treatment. The prognostic signature models constructed based on WDR81 HNRNPH1 combined clinical phenotype–gene showed high predictive efficacy can be applied predict patient risk settings. identified are initiated by mutations promoter levels specific mRNAs lncRNAs. Collectively, changes transcript affect prognosis patients.
Язык: Английский
Процитировано
12