Gut microbiota-derived metabolites as central regulators in metabolic disorders

Gut, Год журнала: 2020, Номер 70(6), С. 1174 - 1182

Опубликована: Дек. 3, 2020

Metabolic disorders represent a growing worldwide health challenge due to their dramatically increasing prevalence. The gut microbiota is crucial actor that can interact with the host by production of diverse reservoir metabolites, from exogenous dietary substrates or endogenous compounds. are associated alterations in composition and function microbiota. Specific classes microbiota-derived notably bile acids, short-chain fatty branched-chain amino trimethylamine N-oxide, tryptophan indole derivatives, have been implicated pathogenesis metabolic disorders. This review aims define key metabolites altered diseases role pathogenesis. They potential biomarkers for early diagnosis prognosis as well promising targets development novel therapeutic tools

Язык: Английский

---

Akkermansia muciniphila is a promising probiotic

Microbial Biotechnology, Год журнала: 2019, Номер 12(6), С. 1109 - 1125

Опубликована: Апрель 21, 2019

Summary Akkermansia muciniphila ( A. ), an intestinal symbiont colonizing in the mucosal layer, is considered to be a promising candidate as probiotics. known have important value improving host metabolic functions and immune responses. Moreover, may modifying cancer treatment. However, most of current researches focus on correlation between diseases, little about causal relationship them. Few intervention studies are limited animal experiments, explored its safety efficacy humans. Therefore, critical analysis knowledge will play foundation for it defined new beneficial microbe. This article review bacteriological characteristics , well with disorders, diseases therapy.

Язык: Английский

---

A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8⁺ T cells in mice

Gut, Год журнала: 2020, Номер 69(11), С. 1988 - 1997

Опубликована: Март 13, 2020

Gut microbiota have been linked to inflammatory bowel disease (IBD) and colorectal cancer (CRC). Akkermansia muciniphila (A. muciniphila) is a gram-negative anaerobic bacterium that selectively decreased in the faecal of patients with IBD, but its causative role molecular mechanism blunting colitis-associated (CAC) remain inconclusive. This study investigates how A. engages immune response CAC.Mice were given dextran sulfate sodium induce colitis, followed by azoxymethane establish CAC or without pasteurised specific outer membrane protein (Amuc_1100) treatment. Faeces from mice IBD CRC collected for 16S rRNA sequencing. The effects Amuc_1100 on acute colitis investigated.A. was significantly reduced CAC. could improve reduction infiltrating macrophages CD8+ cytotoxic T lymphocytes (CTLs) colon. Their treatment also CD16/32+ spleen mesenteric lymph nodes (MLN) mice. elevated PD-1+ CTLs spleen. Moreover, blunted tumourigenesis expanding colon MLN. Remarkably, they activated MLN, as indicated TNF-α induction PD-1downregulation. stimulate activate splenocytes CT26 cell conditioned medium.These data indicate can blunt through modulation CTLs.

Язык: Английский

---

Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

Frontiers in Microbiology, Год журнала: 2020, Номер 11

Опубликована: Фев. 21, 2020

Obesity and its metabolic syndrome, including liver disorders type 2 diabetes, are a worldwide epidemic intimately linked to diet. The gut microbiota interaction has been pointed out as hot topic research at treating obesity related diseases by influencing energy metabolism immune system. In terms of the novel identified beneficial microbes, Akkermansia muciniphila (A.muciniphila ) is colonized in mucosa layer modulates basal metabolism. A.muciniphila consistently correlated with obesity. causal impact on A.muciniphila-treated coming light, which proved variety animal models human studies. characterized player body create great expectation for treatments associated obesity, well considered new generation therapeutic agents. This paper aimed was investigate underlying basic mechanism A.muciniphila-related host interactions recent discoveries, facilitating establish relationship A.muciniphila-associated supplement.

Язык: Английский

---

Polyphenol-Mediated Gut Microbiota Modulation: Toward Prebiotics and Further

Frontiers in Nutrition, Год журнала: 2021, Номер 8

Опубликована: Июнь 28, 2021

The genome of gut microbes encodes a collection enzymes whose metabolic functions contribute to the bioavailability and bioactivity unabsorbed (poly)phenols. Datasets from high throughput sequencing, metabolome measurements, other omics have expanded understanding different modes actions by which (poly)phenols modulate microbiome conferring health benefits host. Progress been made identify direct prebiotic effects (poly)phenols; albeit up date, these compounds are not recognized as prebiotics sensu stricto . Interestingly, certain probiotics strains an enzymatic repertoire, such tannase, α-L-rhamnosidase, phenolic acid reductase, involved in transformation into bioactive metabolites. In vivo studies demonstrated that (poly)phenol-transforming bacteria thrive when provided with substrates. However, taxonomically distinct symbionts phenolic-metabolizing activity has still significantly promoted This is case Akkermansia muciniphila , so-called antiobesity bacterium, responds positively may be partially responsible for formerly attributed molecules. We surmise broad antimicrobial action free ecological niches occupied competing bacteria, thereby allowing bloom beneficial bacteria. review explores capacity promote through their collaborative bacterial utilization inhibitory on potential pathogenic species. propose term duplibiotic describe substrate modulating microbiota both action. (Poly)phenol effect could participate blunting disturbance dysbiosis, positioning dietary strategies therapeutic potential.

Язык: Английский

---

Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

Gut Microbes, Год журнала: 2022, Номер 14(1)

Опубликована: Июль 22, 2022

The human intestine hosts diverse microbial communities that play a significant role in maintaining gut-skin homeostasis. When the relationship between gut microbiome and immune system is impaired, subsequent effects can be triggered on skin, potentially promoting development of skin diseases. mechanisms through which affects health are still unclear. Enhancing our understanding connection needed to find novel ways treat disorders. In this review, we systematically evaluate current data regarding ecology healthy gut, diet, pre- probiotics, antibiotics, their health. We discuss potential axis link skin-associated diseases, such as psoriasis, atopic dermatitis, acne vulgaris, rosacea, alopecia areata, hidradenitis suppurativa. This review will increase impacts conditions aid finding new medications for

Язык: Английский

---

Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis

Gut Microbes, Год журнала: 2021, Номер 13(1)

Опубликована: Янв. 1, 2021

The gut bacterium

Язык: Английский

---

Akkermansia muciniphila Alleviates Dextran Sulfate Sodium (DSS)-Induced Acute Colitis by NLRP3 Activation

Microbiology Spectrum, Год журнала: 2021, Номер 9(2)

Опубликована: Окт. 7, 2021

The gut microbiota and host immune response interaction influences the progression of intestinal inflammatory disease. As a well-recognized next-generation probiotic, Akkermansia muciniphila has been proved to play crucial role in colitis, but its underlying mechanism remains inconclusive.

Язык: Английский

---

Human Gut Microbiome Aging Clock Based on Taxonomic Profiling and Deep Learning

iScience, Год журнала: 2020, Номер 23(6), С. 101199 - 101199

Опубликована: Май 23, 2020

The human gut microbiome is a complex ecosystem that both affects and affected by its host status. Previous metagenomic analyses of microflora revealed associations between specific microbes age. Nonetheless there was no reliable way to tell host's age based on the community composition. Here we developed method predicting hosts' taxonomic profiles using cross-study dataset deep learning. Our best model has an architecture neural network achieves mean absolute error 5.91 years when tested external data. We further advance procedure for inferring role particular during aging defining them as potential biomarkers. described intestinal clock represents unique quantitative provides starting point building succession into single narrative.

Язык: Английский

---

You’ve got male: Sex and the microbiota-gut-brain axis across the lifespan

Frontiers in Neuroendocrinology, Год журнала: 2019, Номер 56, С. 100815 - 100815

Опубликована: Дек. 2, 2019

Язык: Английский

---