Histopathology of Third Trimester Placenta from SARS-CoV-2-Positive Women DOI Creative Commons
Mai He,

Priya Skaria,

Kasey Kreutz

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2020, Номер unknown

Опубликована: Авг. 12, 2020

Background This study aims to investigate whether maternal SARS-CoV-2 status affect placental pathology. Methods A retrospective case-control was conducted by reviewing charts and slides of placentas between April 1 July 24, 2020. Clinical history “COVID-19” were searched in Pathology Database (CoPath). Controls matched with SARS-CoV-2-negative women singleton deliveries the 3 rd -trimester. Individual group, pathological features extracted from pathology reports. Results Twenty-one -trimester, SARS-CoV-2-positive identified compared 20 women. There no significant differences individual or group gross microscopic groups. Within SARS-CoV-2+ there are symptomatic asymptomatic Conclusion Placentas do not demonstrate a specific pattern. Pregnancy complicated COVID-19 during trimester does have demonstrable effect on structure

Язык: Английский

Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens DOI Creative Commons
Rowan M. Karvas, Shafqat Ali Khan, Sonam Verma

и другие.

Cell stem cell, Год журнала: 2022, Номер 29(5), С. 810 - 825.e8

Опубликована: Май 1, 2022

Язык: Английский

Процитировано

107
COVID-19 during pregnancy: an overview of maternal characteristics, clinical symptoms, maternal and neonatal outcomes of 10,996 cases described in 15 countries DOI Creative Commons
Ernesto Antônio Figueiró-Filho, Mark H. Yudin,

Dan Farine

и другие.

Journal of Perinatal Medicine, Год журнала: 2020, Номер 48(9), С. 900 - 911

Опубликована: Окт. 2, 2020

Abstract The objective of this review was to identify the most significant studies reporting on COVID-19 during pregnancy and provide an overview SARS-CoV-2 infection in pregnant women perinatal outcomes. Eligibility criteria included all reports, reviews; case series with more than 100 individuals that reported at least three following: maternal characteristics, clinical presentation, outcomes, outcomes and/or neonatal/perinatal We eight met inclusion criteria, representing 10,966 cases distributed 15 countries around world until July 20, 2020. results our demonstrate symptoms, neonatal almost 11,000 described different are not worse or from general population. suggest affected by respiratory complications COVID-19, when compared also important gestational shift Th1-Th2 immune response, known as a potential contributor severity viral infections pregnancy, counter-regulated enhanced-pregnancy-induced ACE2-Ang-(1–7) axis. Moreover, relatively small number does allow us affirm is aggressive pregnancy. Conversely, we suggest, down-regulation ACE2 receptors induced cell entry might have been detrimental subjects pre-existing deficiency associated This association explain literature.

Язык: Английский

Процитировано

92
SARS-CoV-2 colonization of maternal and fetal cells of the human placenta promotes alteration of local renin-angiotensin system DOI Creative Commons
Sonam Verma, Chetanchandra S. Joshi,

Rachel B. Silverstein

и другие.

Med, Год журнала: 2021, Номер 2(5), С. 575 - 590.e5

Опубликована: Апрель 15, 2021

Язык: Английский

Процитировано

69
COVID-19 and pregnancy: clinical outcomes; mechanisms, and vaccine efficacy DOI Creative Commons
Deepak Kumar, Sonam Verma, Indira U. Mysorekar

и другие.

Translational research, Год журнала: 2022, Номер 251, С. 84 - 95

Опубликована: Авг. 12, 2022

Язык: Английский

Процитировано

50
SARS‐CoV2 and pregnancy: An invisible enemy? DOI Open Access
Sonam Verma, Ebony B. Carter, Indira U. Mysorekar

и другие.

American Journal of Reproductive Immunology, Год журнала: 2020, Номер 84(5)

Опубликована: Июль 17, 2020

Coronavirus disease 2019 or COVID-19 is an emerging viral caused by a member of the betacoronavirus family, SARS-CoV-2. Since its' emergence in December 2019, it has rapidly close to half million fatalities globally. Data regarding impact on pregnancy are limited. Here, we review pathological findings placentas from women who tested positive for SARS-CoV-2 as well information outcomes associated with related and highly pathogenic coronaviruses (ie, severe acute respiratory syndrome (SARS-COV) Middle East syndrome, MERS). We present immune-inflammatory correlates role Renin Angiotensin System pathogenesis pregnancy. Greater understanding placenta will yield important insight into potential therapeutic interventions pregnant COVID-19.

Язык: Английский

Процитировано

69
Histologic and Immunohistochemical Evaluation of 65 Placentas From Women With Polymerase Chain Reaction–Proven Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection DOI Open Access

Daniel Levitan,

Viktoriya London, Rodney A. McLaren

и другие.

Archives of Pathology & Laboratory Medicine, Год журнала: 2021, Номер 145(6), С. 648 - 656

Опубликована: Фев. 17, 2021

Context.— Coronavirus disease 2019 (COVID-19) has been shown to have effects outside of the respiratory system. Placental pathology in setting maternal severe acute syndrome coronavirus 2 (SARS-CoV-2) infection remains a topic great interest because earlier studies mixed results. Objective.— To ascertain whether SARS-CoV-2 is associated with any specific placental histopathology, and evaluate virus's propensity for direct involvement. Design.— Placentas from 65 women polymerase chain reaction–proven underwent histologic evaluation using Amsterdam consensus group criteria terminology. Another 85 placentas without constituted negative control group. A total 64 SARS-CoV-2–positive immunohistochemical staining nucleocapsid protein. Results.— Pathologic findings were divided into vascular malperfusion, fetal chronic inflammatory lesions, amniotic fluid sequence, increased perivillous fibrin, intervillous thrombi, subchorionic meconium-laden macrophages (M-LMs) within membranes, chorangiosis. There was no statistically significant difference prevalence histopathology between SARS-CoV-2–negative groups. evidence virus that viral Conclusions.— Our study results literature review suggest there characteristic most infection. Likewise, involvement by rare event.

Язык: Английский

Процитировано

57
SARS-COV-2 infection in pregnant women and newborns in a Spanish cohort (GESNEO-COVID) during the first wave DOI Creative Commons
Itzíar Carrasco, Mar Muñoz-Chápuli Gutiérrez,

Sara Vigil‐Vázquez

и другие.

BMC Pregnancy and Childbirth, Год журнала: 2021, Номер 21(1)

Опубликована: Апрель 26, 2021

Knowledge about SARS-CoV-2 infection in pregnancy and newborns is scarce. The objective of this study to analyse clinical epidemiological characteristics a cohort women infected with during their exposed gestation.Multicentric observational Spanish hospitals from the GESNEO-COVD cohort, participants RECLIP (Spanish Network Paediatric Clinical Assays). Women confirmed by PCR and/or serology pregnancy, diagnosed delivering period 15/03/2020-31/07/2020 were included. Epidemiological, clinical, analytical data was collected.A total 105 pregnant median 34.1 years old (IQR: 28.8-37.1) 107 Globally, almost 65% had some COVID-19 symptoms more than 43% treated for SARS-COV-2. Overall, 30.8% pneumonia 5 (4.8%) admitted intensive care unit needing invasive mechanical ventilation. There rate 36.2% caesarean sections, which associated (OR: 4.203, CI 95%: 1.473-11.995) lower gestational age at delivery 0.724, 0.578-0.906). prevalence preterm birth 20.6% prematurity gestation 6.970, CI95%: 2.340-22.750) having positive 6.520, 1.840-31.790). All nasopharyngeal negative one positivized 15 days life. Two died, due causes related another unexpected sudden death early skin-to-skin contact after delivery.Although vertical transmission has not been reported prognosis could be worsened as increased risk section deliveries births.

Язык: Английский

Процитировано

56
SARS-CoV-2 can infect and propagate in human placenta explants DOI Creative Commons
Amal Fahmi, Melanie Brügger, Thomas Démoulins

и другие.

Cell Reports Medicine, Год журнала: 2021, Номер 2(12), С. 100456 - 100456

Опубликована: Ноя. 4, 2021

The ongoing SARS-CoV-2 pandemic continues to lead high morbidity and mortality. During pregnancy, severe maternal neonatal outcomes placental pathological changes have been described. We evaluate infection at the maternal-fetal interface using precision-cut slices (PCSs) of human placenta. Remarkably, exposure placenta PCSs leads a full replication cycle with infectious virus release. Moreover, susceptibility tissue relates expression levels ACE2. Viral proteins and/or viral RNA are detected in syncytiotrophoblasts, cytotrophoblasts, villous stroma, possibly Hofbauer cells. While does not cause detectable cytotoxicity or pro-inflammatory cytokine response, an upregulation one order magnitude interferon type III transcripts is measured. In conclusion, our data demonstrate capacity infect propagate constitute basis for further investigation biology interface.

Язык: Английский

Процитировано

48
Analysis of placental pathology after COVID-19 by timing and severity of infection DOI Creative Commons

Chiara M. Corbetta-Rastelli,

Marie Altendahl,

Cynthia Gasper

и другие.

American Journal of Obstetrics & Gynecology MFM, Год журнала: 2023, Номер 5(7), С. 100981 - 100981

Опубликована: Апрель 23, 2023

COVID-19 during pregnancy can have serious effects on outcomes. The placenta acts as an infection barrier to the fetus and may mediate adverse Increased frequency of maternal vascular malperfusion has been detected in placentas patients with compared controls, but little is known about how timing severity affect placental pathology.

Язык: Английский

Процитировано

22
Preeclampsia in the Context of COVID‐19: Mechanisms, Pathophysiology, and Clinical Outcomes DOI
Guilherme de Moraes Nobrega,

Brittany R. Jones,

Indira U. Mysorekar

и другие.

American Journal of Reproductive Immunology, Год журнала: 2024, Номер 92(2)

Опубликована: Авг. 1, 2024

The emergence of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to global COVID-19 pandemic, significantly impacting health pregnant women. Obstetric populations, already vulnerable, face increased morbidity and mortality related COVID-19, aggravated by preexisting comorbidities. Recent studies have shed light on potential correlation between preeclampsia (PE), a leading cause maternal perinatal worldwide, emphasizing significance exploring relationship these two conditions. Here, we review pathophysiological similarities that PE shares with particular focus cases in PE-like SARS-CoV-2 infection. We highlight cellular molecular mechanistic inter-connectivity conditions, for example, regulation renin-angiotensin system, tight junction barrier integrity, complement system. Finally, discuss how pandemic dynamics, including variants vaccination efforts, shaped clinical scenario influenced severity management both PE. Continued research mechanisms infection during pregnancy risk developing from previous infections is warranted delineate complexities interactions improve

Язык: Английский

Процитировано

7