Pregnancy, Preeclampsia, and COVID-19: Susceptibility and Mechanisms: A Review Study. DOI
Babak Sayad, Zeinab Mohseni Afshar,

Feizollah Mansouri

et al.

PubMed, Journal Year: 2022, Volume and Issue: 16(2), P. 64 - 69

Published: April 1, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters cells through angiotensin converting enzyme (ACE2), which expression of its gene increases during pregnancy that is resulted in an enhanced level the ACE2 enzyme. It might enhance risk SARS-CoV-2 infection and complications pregnant women. Although, hypertensive disorders severe with are correlated high comorbidity, these two entities should be discriminated from each other. Also, there a concern about preeclampsia consequently disease 2019 (COVID-19) development So, to answer questions, present review literature was surveyed. seems higher severity COVID-19 among women than non-pregnant more adverse outcomes infected SARS-CoV-2. In addition, association between role gestational hypertension as factors for suggested. However, placenta vertical transmission rare. Various mechanisms could explain COVID-19. Suggested included decreased activity imbalance Ang II Ang-(1-7) preeclampsia, both forms interaction immune system, inflammatory cytokines renin aldosterone system contribution pathogenesis. concluded complications.

Language: Английский

Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens DOI Creative Commons
Rowan M. Karvas, Shafqat Ali Khan, Sonam Verma

et al.

Cell stem cell, Journal Year: 2022, Volume and Issue: 29(5), P. 810 - 825.e8

Published: May 1, 2022

Language: Английский

Citations

103
COVID-19 during pregnancy: an overview of maternal characteristics, clinical symptoms, maternal and neonatal outcomes of 10,996 cases described in 15 countries DOI Creative Commons
Ernesto Antônio Figueiró-Filho, Mark H. Yudin,

Dan Farine

et al.

Journal of Perinatal Medicine, Journal Year: 2020, Volume and Issue: 48(9), P. 900 - 911

Published: Oct. 2, 2020

Abstract The objective of this review was to identify the most significant studies reporting on COVID-19 during pregnancy and provide an overview SARS-CoV-2 infection in pregnant women perinatal outcomes. Eligibility criteria included all reports, reviews; case series with more than 100 individuals that reported at least three following: maternal characteristics, clinical presentation, outcomes, outcomes and/or neonatal/perinatal We eight met inclusion criteria, representing 10,966 cases distributed 15 countries around world until July 20, 2020. results our demonstrate symptoms, neonatal almost 11,000 described different are not worse or from general population. suggest affected by respiratory complications COVID-19, when compared also important gestational shift Th1-Th2 immune response, known as a potential contributor severity viral infections pregnancy, counter-regulated enhanced-pregnancy-induced ACE2-Ang-(1–7) axis. Moreover, relatively small number does allow us affirm is aggressive pregnancy. Conversely, we suggest, down-regulation ACE2 receptors induced cell entry might have been detrimental subjects pre-existing deficiency associated This association explain literature.

Language: Английский

Citations

92
SARS-CoV-2 colonization of maternal and fetal cells of the human placenta promotes alteration of local renin-angiotensin system DOI Creative Commons
Sonam Verma, Chetanchandra S. Joshi,

Rachel B. Silverstein

et al.

Med, Journal Year: 2021, Volume and Issue: 2(5), P. 575 - 590.e5

Published: April 15, 2021

Language: Английский

Citations

69
COVID-19 and pregnancy: clinical outcomes; mechanisms, and vaccine efficacy DOI Creative Commons
Deepak Kumar, Sonam Verma, Indira U. Mysorekar

et al.

Translational research, Journal Year: 2022, Volume and Issue: 251, P. 84 - 95

Published: Aug. 12, 2022

Language: Английский

Citations

49
Impact of COVID-19 on Utilization of Healthcare Services Among People Living with HIV (PLHIV): A Systematic Review DOI Creative Commons
Enyinnaya Ukaegbu,

Maulenkul Tilektes,

Antonio Sarría‐Santamera

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(1), P. 111 - 111

Published: Jan. 14, 2025

Background and Objectives: People living with HIV/AIDS have been impacted notably by the COVID-19 pandemic in diverse dimensions. Although some impacts of on PLHIV well documented, there is still insufficient research that captures overall understanding implications for healthcare utilization among PLHIV. This review aims to evaluate impact PLHIV, narrowing it down women HIV/AIDS. Materials Methods: An electronic database search primary studies obtained information from health facility data regarding since 2020 was carried out according PRISMA statement. A combination terms, e.g., “COVID-19 pandemic”, “SARS-CoV-2”, “Health services utilization”, “People Human immunodeficiency virus”, included. Results: There an decline such as medical consultations, ART uptake, viral load monitoring at centers forefront care delivery. However, countries sub-Saharan African region showed a progressive service increase over pandemic. scarcity populations Other methods delivery telemedicine postage were instrumental HIV services. Conclusions: The reduced uptake need boost strengthen emergency preparedness particularly HIV/AIDS, during pandemics further harness maximize use contemporary other than traditional ones.

Language: Английский

Citations

1
SARS‐CoV2 and pregnancy: An invisible enemy? DOI Open Access
Sonam Verma, Ebony B. Carter, Indira U. Mysorekar

et al.

American Journal of Reproductive Immunology, Journal Year: 2020, Volume and Issue: 84(5)

Published: July 17, 2020

Coronavirus disease 2019 or COVID-19 is an emerging viral caused by a member of the betacoronavirus family, SARS-CoV-2. Since its' emergence in December 2019, it has rapidly close to half million fatalities globally. Data regarding impact on pregnancy are limited. Here, we review pathological findings placentas from women who tested positive for SARS-CoV-2 as well information outcomes associated with related and highly pathogenic coronaviruses (ie, severe acute respiratory syndrome (SARS-COV) Middle East syndrome, MERS). We present immune-inflammatory correlates role Renin Angiotensin System pathogenesis pregnancy. Greater understanding placenta will yield important insight into potential therapeutic interventions pregnant COVID-19.

Language: Английский

Citations

68
Histologic and Immunohistochemical Evaluation of 65 Placentas From Women With Polymerase Chain Reaction–Proven Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection DOI Open Access

Daniel Levitan,

Viktoriya London, Rodney A. McLaren

et al.

Archives of Pathology & Laboratory Medicine, Journal Year: 2021, Volume and Issue: 145(6), P. 648 - 656

Published: Feb. 17, 2021

Context.— Coronavirus disease 2019 (COVID-19) has been shown to have effects outside of the respiratory system. Placental pathology in setting maternal severe acute syndrome coronavirus 2 (SARS-CoV-2) infection remains a topic great interest because earlier studies mixed results. Objective.— To ascertain whether SARS-CoV-2 is associated with any specific placental histopathology, and evaluate virus's propensity for direct involvement. Design.— Placentas from 65 women polymerase chain reaction–proven underwent histologic evaluation using Amsterdam consensus group criteria terminology. Another 85 placentas without constituted negative control group. A total 64 SARS-CoV-2–positive immunohistochemical staining nucleocapsid protein. Results.— Pathologic findings were divided into vascular malperfusion, fetal chronic inflammatory lesions, amniotic fluid sequence, increased perivillous fibrin, intervillous thrombi, subchorionic meconium-laden macrophages (M-LMs) within membranes, chorangiosis. There was no statistically significant difference prevalence histopathology between SARS-CoV-2–negative groups. evidence virus that viral Conclusions.— Our study results literature review suggest there characteristic most infection. Likewise, involvement by rare event.

Language: Английский

Citations

56
SARS-COV-2 infection in pregnant women and newborns in a Spanish cohort (GESNEO-COVID) during the first wave DOI Creative Commons
Itzíar Carrasco, Mar Muñoz-Chápuli Gutiérrez,

Sara Vigil‐Vázquez

et al.

BMC Pregnancy and Childbirth, Journal Year: 2021, Volume and Issue: 21(1)

Published: April 26, 2021

Knowledge about SARS-CoV-2 infection in pregnancy and newborns is scarce. The objective of this study to analyse clinical epidemiological characteristics a cohort women infected with during their exposed gestation.Multicentric observational Spanish hospitals from the GESNEO-COVD cohort, participants RECLIP (Spanish Network Paediatric Clinical Assays). Women confirmed by PCR and/or serology pregnancy, diagnosed delivering period 15/03/2020-31/07/2020 were included. Epidemiological, clinical, analytical data was collected.A total 105 pregnant median 34.1 years old (IQR: 28.8-37.1) 107 Globally, almost 65% had some COVID-19 symptoms more than 43% treated for SARS-COV-2. Overall, 30.8% pneumonia 5 (4.8%) admitted intensive care unit needing invasive mechanical ventilation. There rate 36.2% caesarean sections, which associated (OR: 4.203, CI 95%: 1.473-11.995) lower gestational age at delivery 0.724, 0.578-0.906). prevalence preterm birth 20.6% prematurity gestation 6.970, CI95%: 2.340-22.750) having positive 6.520, 1.840-31.790). All nasopharyngeal negative one positivized 15 days life. Two died, due causes related another unexpected sudden death early skin-to-skin contact after delivery.Although vertical transmission has not been reported prognosis could be worsened as increased risk section deliveries births.

Language: Английский

Citations

56
SARS-CoV-2 can infect and propagate in human placenta explants DOI Creative Commons
Amal Fahmi, Melanie Brügger, Thomas Démoulins

et al.

Cell Reports Medicine, Journal Year: 2021, Volume and Issue: 2(12), P. 100456 - 100456

Published: Nov. 4, 2021

The ongoing SARS-CoV-2 pandemic continues to lead high morbidity and mortality. During pregnancy, severe maternal neonatal outcomes placental pathological changes have been described. We evaluate infection at the maternal-fetal interface using precision-cut slices (PCSs) of human placenta. Remarkably, exposure placenta PCSs leads a full replication cycle with infectious virus release. Moreover, susceptibility tissue relates expression levels ACE2. Viral proteins and/or viral RNA are detected in syncytiotrophoblasts, cytotrophoblasts, villous stroma, possibly Hofbauer cells. While does not cause detectable cytotoxicity or pro-inflammatory cytokine response, an upregulation one order magnitude interferon type III transcripts is measured. In conclusion, our data demonstrate capacity infect propagate constitute basis for further investigation biology interface.

Language: Английский

Citations

48
Analysis of placental pathology after COVID-19 by timing and severity of infection DOI Creative Commons

Chiara M. Corbetta-Rastelli,

Marie Altendahl,

Cynthia Gasper

et al.

American Journal of Obstetrics & Gynecology MFM, Journal Year: 2023, Volume and Issue: 5(7), P. 100981 - 100981

Published: April 23, 2023

COVID-19 during pregnancy can have serious effects on outcomes. The placenta acts as an infection barrier to the fetus and may mediate adverse Increased frequency of maternal vascular malperfusion has been detected in placentas patients with compared controls, but little is known about how timing severity affect placental pathology.

Language: Английский

Citations

21