Laundry detergents and surfactants‐induced eosinophilic airway inflammation by increasing IL‐33 expression and activating ILC2s

Allergy, Год журнала: 2023, Номер 78(7), С. 1878 - 1892

Опубликована: Май 11, 2023

Epidemiological studies demonstrated that cleaning work and frequent use of products are risk factors for asthma. Laundry detergents have been reported to epithelial barrier-opening effects. However, whether laundry directly induce airway inflammation its mechanisms in vivo remain be elucidated.Two commercial two commonly used surfactants cosmetics (sodium lauryl sulfate sodium dodecyl benzene sulfonate) were intranasally administered mice. Lungs analyzed using flow cytometry, histology, ELISA, quantitative PCR. Human bronchial cells stimulated with PCR western blotting. Involvement oxidative stress was assessed an antioxidant. Dust samples from homes determine their detergent content by measuring critical micelle concentration (CMC).The surfactants-induced eosinophilic accompanied increased IL-33 expression activation group 2 innate lymphoid (ILC2s). Detergent-induced significantly attenuated Rag2-/- Il2rg-/- , Il33-/- mice, also wild-type mice treated NAC. airways NAC treatment, both vitro. CMCs found all the tested dust extracts, they differed among homes.The through cell ILC2 activation. They induced stress. Furthermore, residues present house presumably inhaled into daily life.

Язык: Английский

---

The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions

Seminars in Immunology, Год журнала: 2023, Номер 70, С. 101846 - 101846

Опубликована: Окт. 4, 2023

Since the 1960 s, our health has been compromised by exposure to over 350,000 newly introduced toxic substances, contributing current pandemic in allergic, autoimmune and metabolic diseases. The "Epithelial Barrier Theory" postulates that these diseases are exacerbated persistent periepithelial inflammation (epithelitis) triggered a wide range of epithelial barrier-damaging substances as well genetic susceptibility. barrier serves body's primary physical, chemical, immunological against external stimuli. A leaky facilitates translocation microbiome from surface afflicted tissues interepithelial even deeper subepithelial locations. In turn, opportunistic bacterial colonization, microbiota dysbiosis, local impaired tissue regeneration remodelling follow. Migration inflammatory cells susceptible contributes damage inflammation, initiating aggravating many chronic objective this review is highlight evaluate recent studies on physiology its role pathogenesis light theory.

Язык: Английский

---

Social determinants of health as drivers of fungal disease

EClinicalMedicine, Год журнала: 2023, Номер 66, С. 102325 - 102325

Опубликована: Ноя. 18, 2023

Disparities in social determinants of health (SDOH) play a significant role causing inequities globally. The physical environment, including housing and workplace can increase the prevalence spread fungal infections. A number professions are associated with increased infection risk low pay, which may be linked to crowded sub-optimal living conditions, exposure organisms, lack access quality care, for infection. Those involved displaced from areas armed conflict have an invasive Lastly, plant pathogens already threaten food security, will become more problematic global climate change. Taken together, disparities SDOH contracting More emphasis needs placed on systematic approaches better understand impact reducing these disparities.

Язык: Английский

---

Relationship of long-term air pollution exposure with asthma and rhinitis in Italy: an innovative multipollutant approach

Environmental Research, Год журнала: 2023, Номер 224, С. 115455 - 115455

Опубликована: Фев. 13, 2023

air pollution is a complex mixture; novel multipollutant approaches could help understanding the health effects of multiple concomitant exposures to pollutants.to assess relationship long-term exposure with prevalence respiratory/allergic symptoms and diseases in an Italian multicenter study using single approaches.14420 adults living 6 cities (Ancona, Pavia, Pisa, Sassari, Turin, Verona) were investigated 2005-2011 within 11 different cohorts. Questionnaire information about risk factors outcomes was collected. Machine learning derived mean annual concentrations PM10, PM2.5, NO2 summer O3 (μg/m3) at residential level (1-km resolution) used for period 2013-2015. The associations between four pollutants symptoms/diseases assessed two approaches: a) logistic regression models (single-pollutant models), b) principal component (multipollutant models). All adjusted age, sex, education level, smoking habits, season interview, climatic index included random intercept cohorts.the three-year average (± standard deviation) were: 20.3 ± 6.8 μg/m3 29.2 7.0 28.0 11.2 NO2, 70.9 4.3 O3. Through following emerged: PM10 PM2.5 related 14-25% increased odds rhinitis, 23-34% asthma 30-33% night awakening; 6-9% 7-8% 12% associated 37% attacks. Overall, Odds Ratios estimated through attenuated when compared those single-pollutant models.this enabled obtain new on adults, applying innovative methods assessment analyses.

Язык: Английский

---

The One Health approach for allergic diseases and asthma

Allergy, Год журнала: 2023, Номер 78(7), С. 1777 - 1793

Опубликована: Апрель 29, 2023

Abstract The One Health approach is a collaborative and interdisciplinary strategy with focal point on human, animal, environmental health interconnections. can support the advanced management of allergic diseases asthma, as complex, multifactorial driven by interactions between resilience response to exposome. According concept asthma arising from exposures wide range allergens, infectious agents irritants (such pollutants) occurring indoors outdoors be heavily influenced (air, water, soil quality) intermingled animal health. These are currently impacted climate change, land use, urbanization, migration, overpopulation, many more. Thus, coordinated address underlying factors that contribute development needs focus environment, altogether. Collaborative efforts across multiple sectors, including public health, veterinary medicine, science, community engagement thus needed. A activities, monitoring surveillance data, targeted interventions reduce allergens irritants, research mechanisms drive needed move field forward. In this consensus document elaborated European Academy Allergy Clinical Immunology (EAACI) American Allergy, Asthma, (AAAAI) under practical allergy (PRACTALL) series, we provide insights into Heath aiming framework for addressing complex nature asthma.

Язык: Английский

---