ABSTRACT
The
One
Health
approach
emphasizes
the
interconnectedness
of
human,
animal,
and
environmental
health,
recognizing
that
health
each
is
interdependent
influenced
by
shared
ecosystems.
Nutrition
research
plays
a
critical
role
in
improving
outcomes
across
these
domains,
with
implications
for
sustainability
food
security.
Organ‐on‐chip
(OoC)
technologies
have
emerged
as
innovative
tools
replicating
key
organ
functions,
supporting
disease
modeling,
drug
discovery,
personalized
medicine.
They
also
hold
promise
alternatives
to
traditional
animal
models.
This
systematic
review
examines
potential
OoC
within
framework
nutrition
research,
focusing
on
(1)
their
ability
replicate
human
(2)
applications
safety
ecotoxicology,
(3)
use
studying
components’
effects.
Challenges
future
directions
adoption
are
discussed.
Although
fully
complexity
vivo
physiology
remains
challenge,
OoCs
offer
promising
platform
simulate
functions
interactions.
These
systems
significant
advancing
assessments,
impacts
addressing
systems.
such
standardization,
scalability,
accessibility,
biases
toward
models
remain.
Despite
hurdles,
current
advancements
underscore
versatility
OoCs,
positioning
them
valuable
driving
innovation
feed
safety,
ecotoxicology.
With
continued
progress,
poised
make
contributions
goals
framework.
International Immunology,
Год журнала:
2024,
Номер
36(5), С. 211 - 222
Опубликована: Янв. 16, 2024
Abstract
The
epithelial
barrier
theory
links
the
recent
rise
in
chronic
non-communicable
diseases,
notably
autoimmune
and
allergic
disorders,
to
environmental
agents
disrupting
barrier.
Global
pollution
toxic
agent
exposure
have
worsened
over
six
decades
because
of
uncontrolled
growth,
modernization,
industrialization,
affecting
human
health.
Introducing
new
chemicals
without
any
reasonable
control
their
health
effects
through
these
years
has
led
documented
adverse
effects,
especially
on
skin
mucosal
barriers.
These
substances,
such
as
particulate
matter,
detergents,
surfactants,
food
emulsifiers,
micro-
nano-plastics,
diesel
exhaust,
cigarette
smoke,
ozone,
been
shown
compromise
integrity.
This
disruption
is
linked
opening
tight-junction
barriers,
inflammation,
cell
death,
oxidative
stress,
metabolic
regulation.
Consideration
must
be
given
interplay
underlying
inflammatory
medications,
affected
tissues.
review
article
discusses
detrimental
effect
barrier-damaging
compounds
involves
cellular
molecular
mechanisms.
Allergy,
Год журнала:
2024,
Номер
79(6), С. 1485 - 1500
Опубликована: Март 4, 2024
The
epithelial
barriers
of
the
skin,
gut,
and
respiratory
tract
are
critical
interfaces
between
environment
host,
they
orchestrate
both
homeostatic
pathogenic
immune
responses.
mechanisms
underlying
barrier
dysfunction
in
allergic
inflammatory
conditions,
such
as
atopic
dermatitis,
food
allergy,
eosinophilic
oesophagitis,
rhinitis,
chronic
rhinosinusitis,
asthma,
complex
influenced
by
exposome,
microbiome,
individual
genetics,
epigenetics.
Here,
we
review
role
digestive
tract,
airways
maintaining
homeostasis,
how
influence
occurrence
progression
current
treatments
target
epithelium
to
improve
symptoms
these
disorders,
what
unmet
needs
identification
treatment
disorders.
Seminars in Immunology,
Год журнала:
2023,
Номер
70, С. 101846 - 101846
Опубликована: Окт. 4, 2023
Since
the
1960
s,
our
health
has
been
compromised
by
exposure
to
over
350,000
newly
introduced
toxic
substances,
contributing
current
pandemic
in
allergic,
autoimmune
and
metabolic
diseases.
The
"Epithelial
Barrier
Theory"
postulates
that
these
diseases
are
exacerbated
persistent
periepithelial
inflammation
(epithelitis)
triggered
a
wide
range
of
epithelial
barrier-damaging
substances
as
well
genetic
susceptibility.
barrier
serves
body's
primary
physical,
chemical,
immunological
against
external
stimuli.
A
leaky
facilitates
translocation
microbiome
from
surface
afflicted
tissues
interepithelial
even
deeper
subepithelial
locations.
In
turn,
opportunistic
bacterial
colonization,
microbiota
dysbiosis,
local
impaired
tissue
regeneration
remodelling
follow.
Migration
inflammatory
cells
susceptible
contributes
damage
inflammation,
initiating
aggravating
many
chronic
objective
this
review
is
highlight
evaluate
recent
studies
on
physiology
its
role
pathogenesis
light
theory.
Reviews in Aquaculture,
Год журнала:
2024,
Номер
16(4), С. 1787 - 1797
Опубликована: Май 1, 2024
Abstract
The
aquaculture
sector
is
currently
experiencing
a
global
disease
crisis.
Emerging
bacterial
diseases—often
opportunistic
or
syndromic—have
collapsed
production
in
nations
across
the
world.
Losses
shrimp
industry
associated
with
Vibrio
spp.
exceed
40%
of
capacity.
This
paper
reviews
potential
drivers
syndromic
diseases
involving
pathogens
affecting
aquaculture.
We
provide
key
examples
from
major
industries
where
such
conditions
have
prompted
greater
antibiotic
use
and
resulted
significant
mortality.
challenge
conventional
definitions
propose
fluid
categorisation
that
acknowledges
continuum
host
adaptation
complexity
microbial
ecology.
discuss
implications
environmental
dietary
stressors
as
climate
change,
coastal
eutrophication
pollution,
transition
to
plant‐based
feeds,
which
been
linked
impaired
epithelial
barrier
function,
gut
health
disorders
increased
susceptibility.
critique
‘one‐pathogen
one‐disease’
paradigm,
suggesting
Rothman's
causal
pie
model
more
useful
for
understanding
infections
it
emphasises
multicausal
nature
disease.
viral
interactions
aquatic
occurrence
resulting
damage
eukaryotic
parasites
increasing
frequency
severity
interventions
control
parasites.
recognise
need
corroborative
evidence
validate
rise
trend,
we
advocate
application
nuanced
causation
models
reduce
incidence
improve
sustainability
industry.
Current Allergy and Asthma Reports,
Год журнала:
2024,
Номер
24(7), С. 331 - 345
Опубликована: Июнь 17, 2024
Abstract
Purpose
of
Review
Modernization
and
Westernization
in
industrialized
developing
nations
is
associated
with
a
substantial
increase
chronic
noncommunicable
diseases.
This
transformation
has
far-reaching
effects
on
lifestyles,
impacting
areas
such
as
economics,
politics,
social
life,
culture,
all
which,
turn,
have
diverse
influences
public
health.
Loss
contact
nature,
alternations
the
microbiota,
processed
food
consumption,
exposure
to
environmental
pollutants
including
chemicals,
increased
stress
decreased
physical
activity
jointly
result
increases
frequency
inflammatory
disorders
allergies
many
autoimmune
neuropsychiatric
review
aims
investigate
relationship
between
Western
lifestyle
disorders.
Recent
Findings
Several
hypotheses
been
put
forth
trying
explain
observed
these
diseases,
‘
Hygiene
Hypothesis
’,
Old
Friends
Biodiversity
Dysbiosi
s’.
The
recently
introduced
Epithelial
Barrier
Theory
’
incorporates
former
suggests
that
toxic
substances
cleaning
agents,
laundry
dishwasher
detergents,
shampoos,
toothpastes,
well
microplastic,
packaged
air
pollution
damage
epithelium
our
skin,
lungs
gastrointestinal
system.
barrier
disruption
leads
biodiversity
microbiome
development
opportunistic
pathogen
colonization,
which
upon
interaction
immune
system,
initiates
local
systemic
inflammation.
Summary
Gaining
deeper
comprehension
interplay
environment,
system
provides
data
assist
legally
regulating
usage
substances,
enable
nontoxic
alternatives
mitigate
challenges
essential
for
fostering
harmonious
healthy
global
environment.
Abstract
The
prevalence
of
many
chronic
noncommunicable
diseases
has
been
steadily
rising
over
the
past
six
decades.
During
this
time,
350,000
new
chemical
substances
have
introduced
to
lives
humans.
In
recent
years,
epithelial
barrier
theory
came
light
explaining
growing
and
exacerbations
these
worldwide.
It
attributes
their
onset
a
functionally
impaired
triggered
by
toxicity
exposed
substances,
associated
with
microbial
dysbiosis,
immune
system
activation,
inflammation.
Diseases
encompassed
share
common
features
such
as
an
increased
after
1960s
or
2000s
that
cannot
(solely)
be
accounted
for
emergence
improved
diagnostic
methods.
Other
traits
include
defects,
dysbiosis
loss
commensals
colonization
opportunistic
pathogens,
circulating
inflammatory
cells
cytokines.
addition,
practically
unrelated
fulfill
criteria
started
emerge
multimorbidities
during
last
Here,
we
provide
comprehensive
overview
discuss
evidence
similarities
epidemiology,
genetic
susceptibility,
dysfunction,
tissue
Allergy,
Год журнала:
2024,
Номер
79(4), С. 937 - 948
Опубликована: Фев. 5, 2024
Abstract
Background
Dupilumab
is
used
for
the
treatment
of
atopic
dermatitis
(AD).
Approximately
one
third
AD
patients
develop
a
dupilumab‐associated
ocular
surface
disease
(DAOSD),
which
pathomechanism
poorly
understood.
This
study
aimed
at
investigating
inflammatory
markers
in
tear
fluids
on
dupilumab
therapy.
Methods
Tear
were
collected
from
with
DAOSD
(ADwDAOSD),
without
(ADw/oDAOSD),
and
non‐AD
before
during
therapy,
analyzed
using
specialized
proteomic
approach
quantifying
markers.
The
microbiome
was
determined
by
next
generation
sequencing
technology.
Results
Upon
an
upregulation
31
observed
compared
to
baseline
patients.
While
IL‐12B
upregulated
both
ADwDAOSD
ADw/oDAOSD
groups,
pattern
significantly
differed
between
groups
over
time.
In
group,
shift
mixed
Th2/Th17
toward
Th1/Th17
profile
under
observed.
Furthermore,
remodeling
fibrosis
seen
DAOSD.
Semantic
map
hierarchical
cluster
analyses
marker
expression
revealed
four
clusters
distinguishing
as
well
patient
groups.
pilot
study,
therapy
associated
decrease
richness
microbiome.
Conclusions
characterized
cytokine
known
promote
fibrosis.
might
serve
prognostic
factor
Pediatric Allergy and Immunology,
Год журнала:
2024,
Номер
35(9)
Опубликована: Сен. 1, 2024
Abstract
Background
Consumption
of
ultra‐processed
foods
[UPFs]
may
be
associated
with
negative
health
outcomes.
Limited
data
exist
regarding
the
potential
role
UPFs
in
occurrence
allergic
diseases.
The
underlying
mechanisms
underpinning
any
such
associations
are
also
poorly
elucidated.
Methods
We
performed
a
systematic
review
and
narrative
evidence
synthesis
available
literature
to
assess
between
UPF
consumption
pediatric
allergy
outcomes
(
n
=
26
papers),
including
on
association
seen
gut
microbiome
16
papers)
or
immune
system
3
structure
function
following
PRISMA
guidelines.
Results
Dietary
exposure
fructose,
carbonated
soft
drinks,
sugar
intake
was
an
increased
risk
asthma,
rhinitis,
food
allergies
children.
Commercial
baby
childhood
allergy.
Childhood
fruit
juices,
sugar‐sweetened
beverages,
high
carbohydrate
UPFs,
monosodium
glutamate,
advanced
glycated
end‐products
(AGEs)
Exposure
common
ingredients
seem
diseases
as
wheezing,
allergies,
atopic
dermatitis,
many,
but
not
all
studies.
Conclusion
More
preclinical
clinical
studies
required
better
define
link
asthma.
These
observational
ideally
require
supporting
clearly
defined
consumption,
validated
dietary
measures,
mechanistic
assessments
definitively
