Immuno,
Год журнала:
2024,
Номер
4(3), С. 247 - 265
Опубликована: Авг. 21, 2024
The
planar
cell
polarity
(PCP)
of
epithelial
ciliated
cells
is
essential
for
effective
mucociliary
clearance
(MCC)
in
the
sinonasal
mucosa.
We
hypothesize
that
MCC
coordination
impaired
nasal
polyp
(NP)
mucosae
due
to
suppressed
expression
a
series
CPLANE
(ciliogenesis
and
effector)
complex
proteins
chronic
rhinosinusitis
(CRS)
patients.
To
investigate
this
hypothesis,
we
subjected
mucosal
samples
live
video
recording
measure
transport
velocity
(MCTV)
scanning
electron
microscopy
evaluate
surface
morphology.
distribution
panel
PCP
proteins,
e.g.,
WDPCP
FUZ,
were
investigated
relation
inflammatory
cytokine
levels
clinical
features.
mean
MCTV
NP
was
significantly
lower
than
inferior
turbinate
mucosae.
CRS
group
with
NPs
(CRSwNP
group)
(n
=
28)
showed
increased
IL-13
CCL26
mRNA
compared
patients
without
25)
controls
30).
FUZ
decreased
ethmoid
sinus
CRSwNP
protein
reduced
cytoplasmic
region
conclude
suppression
responsible
polyps
type-2
inflammation.
This
mechanism
might
explain
potential
worsening
symptoms
CRSwNP.
International Immunopharmacology,
Год журнала:
2025,
Номер
148, С. 113972 - 113972
Опубликована: Янв. 18, 2025
The
epithelial
barrier,
previously
regarded
only
as
a
physical
defense,
is
now
understood
to
play
vital
role
in
immune
responses
and
the
regulation
of
inflammation.
Allergic
rhinitis
(AR)
prevalent
chronic
inflammatory
condition
nasal
mucosa,
with
House
Dust
Mite
(HDM)
identified
significant
inhalant
allergen
that
can
impair
this
barrier.
IL-24
has
emerged
key
cytokine
allergic
diseases,
involved
maintaining
cell
homeostasis.
Nevertheless,
underlying
mechanisms
these
effects
remain
inadequately
understood.
This
study
explores
HDM-induced
secretion
mucosal
barrier
impairment
using
patient
animal
tissue
samples.
Our
results
confirm
HDM
sensitization
triggers
changes
cavity,
acting
mediator
type
2
inflammation
AR
severity.
enhances
via
P38
MAPK
pathway
transcription
factor
AP-1,
while
downregulates
occludin
ZO-1
expression
through
STAT1/STAT3
signaling
pathway,
compromising
function
increasing
permeability.
Furthermore,
promotes
IL-33
secretion,
further
exacerbating
response
AR.
These
findings
clarify
disruption
HDM-sensitized
suggest
modulating
may
serve
promising
therapeutic
strategy
restore
integrity
Immunologic Research,
Год журнала:
2025,
Номер
73(1)
Опубликована: Март 11, 2025
The
epithelial
barrier
in
different
organs
is
the
first
line
of
defense
against
environmental
insults
and
allergens,
with
type
2
immunity
serving
as
a
protective
function.
Genetic
factors,
biological
chemical
from
surrounding
environment
altered
regulate
homeostasis
through
disruption
tight
junction
proteins
or
dilated
intercellular
spaces.
Recent
studies
suggest
that
dysfunction
contributes
to
pathologic
alteration
diseases
immune
dysregulation
including
(but
not
limited
to)
atopic
dermatitis,
prurigo
nodularis,
asthma,
chronic
rhinosinusitis
nasal
polyps,
eosinophilic
esophagitis.
In
this
review,
we
summarized
current
understanding
its
interaction
inflammation
across
organs,
discussed
role
pathogenesis
inflammation.
addition,
recent
progresses
emerging
restorative
therapies
are
reviewed.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 20, 2025
The
airway
epithelial
barrier
is
the
first
defence
against
aeroallergens.
Nasal
cells
(NECs)
are
vital
in
regulating
innate
and
adaptive
mucosal
immunity
allergic
rhinitis
(AR).
Tregs
produce
cytokines
essential
for
immunomodulatory
activities
allergen
immunotherapy.
Understanding
relationship
between
NECs
hyperresponsiveness
network
developing
novel
treatments.
Using
an
vitro
human
Treg-NEC
co-culture
system
of
AR
health
control
group,
chemokine
expression
profiles
were
examined
using
immunohistochemistry,
RT-PCR,
ELISA,
functional
surface
markers
detected
flow
cytometric
analysis.
Correlation
analysis
was
performed
derived
from
CD4+CD8+Foxp3+
group
after
co-culture,
including
TSLP/CTLA4,
CCL1/CTLA4,
TSLP/CCR8,
CCL1/CCR8.
CCR8
CTLA-4
expressions
co-culturing
higher
than
single
culture.
Following
Derp1
stimulation,
TSLP,
IL-25
TGF-β
+
increased.
CCL1
mRNA
lower
group.
In
TSLP
higher,
protein
levels
decreased.
There
no
significant
differences
IL-25,
IL-10.
When
Treg
added,
changes
similar
to
that
observed
pNECs.
After
CCL1/CCR8
positively
correlated
AR.
Human
pNECs
can
communicate
with
directly,
may
be
pathway
play
a
key
role
immune
Eye & ENT Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 5, 2025
Abstract
Yes‐associated
protein
(YAP),
a
pivotal
of
the
Hippo
signaling
pathway,
plays
crucial
role
in
regulating
cell
proliferation
and
differentiation.
Emerging
evidence
highlights
its
significance
respiratory
inflammatory
disorders,
including
chronic
rhinosinusitis,
allergic
rhinitis.
This
review
delves
into
impact
YAP
on
individuals
affected
by
these
ailments,
with
specific
focus
it
nasal
mucosal
epithelial
cells.
We
further
explore
interplay
between
mediators,
outlining
pathological
mechanisms
through
which
contributes
to
tissue
restructuring
contexts.
Despite
advancements,
gaps
persist
understanding
YAP's
broader
clinical
applications.
Future
research
directions
are
proposed
this
article
bridge
knowledge
gaps.
