Progress in Cellular Mechanisms of Chronic Rhinosinusitis DOI Creative Commons

Jing-Xian Li,

Zhichao Wang, Zheng Liu

et al.

Fundamental Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Type 2 immunity in allergic diseases DOI Creative Commons
İsmail Öğülür, Yasutaka Mitamura,

Duygu Yazıcı

et al.

Cellular and Molecular Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Language: Английский

Citations

7
Quercetin restores respiratory mucosal barrier dysfunction in Mycoplasma gallisepticum-infected chicks by enhancing Th2 immune response DOI
Shun Wang,

Liyang Guo,

Fuhua Gu

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 133, P. 155953 - 155953

Published: Aug. 12, 2024

Language: Английский

Citations

5
Saccharomyces boulardii alleviates allergic asthma by restoring gut microbiota and metabolic homeostasis via up-regulation of METTL3 in an m6A-dependent manner DOI
Da Liu, Lang Hu, Yue Yang

et al.

Immunology Letters, Journal Year: 2024, Volume and Issue: 267, P. 106853 - 106853

Published: March 20, 2024

Language: Английский

Citations

4
House dust mite induced mucosal barrier dysfunction and type 2 inflammatory responses via the MAPK/AP-1/IL-24 Signaling pathway in allergic rhinitis DOI Creative Commons

Siyao Zhang,

Wen‐Lan Wu, Min Gu

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 113972 - 113972

Published: Jan. 18, 2025

The epithelial barrier, previously regarded only as a physical defense, is now understood to play vital role in immune responses and the regulation of inflammation. Allergic rhinitis (AR) prevalent chronic inflammatory condition nasal mucosa, with House Dust Mite (HDM) identified significant inhalant allergen that can impair this barrier. IL-24 has emerged key cytokine allergic diseases, involved maintaining cell homeostasis. Nevertheless, underlying mechanisms these effects remain inadequately understood. This study explores HDM-induced secretion mucosal barrier impairment using patient animal tissue samples. Our results confirm HDM sensitization triggers changes cavity, acting mediator type 2 inflammation AR severity. enhances via P38 MAPK pathway transcription factor AP-1, while downregulates occludin ZO-1 expression through STAT1/STAT3 signaling pathway, compromising function increasing permeability. Furthermore, promotes IL-33 secretion, further exacerbating response AR. These findings clarify disruption HDM-sensitized suggest modulating may serve promising therapeutic strategy restore integrity

Language: Английский

Citations

0
Interaction between nasal epithelial cells and Tregs in allergic rhinitis responses to allergen via CCL1/CCR8 DOI Creative Commons
Jichao Sha, Maolin Yang, Yingying Lei

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 20, 2025

The airway epithelial barrier is the first defence against aeroallergens. Nasal cells (NECs) are vital in regulating innate and adaptive mucosal immunity allergic rhinitis (AR). Tregs produce cytokines essential for immunomodulatory activities allergen immunotherapy. Understanding relationship between NECs hyperresponsiveness network developing novel treatments. Using an vitro human Treg-NEC co-culture system of AR health control group, chemokine expression profiles were examined using immunohistochemistry, RT-PCR, ELISA, functional surface markers detected flow cytometric analysis. Correlation analysis was performed derived from CD4+CD8+Foxp3+ group after co-culture, including TSLP/CTLA4, CCL1/CTLA4, TSLP/CCR8, CCL1/CCR8. CCR8 CTLA-4 expressions co-culturing higher than single culture. Following Derp1 stimulation, TSLP, IL-25 TGF-β + increased. CCL1 mRNA lower group. In TSLP higher, protein levels decreased. There no significant differences IL-25, IL-10. When Treg added, changes similar to that observed pNECs. After CCL1/CCR8 positively correlated AR. Human pNECs can communicate with directly, may be pathway play a key role immune

Language: Английский

Citations

0
Chronic Rhinosinusitis, Asthma, and Gastroesophageal Reflux: Epidemiology, Pathophysiology, and Comorbidity DOI Creative Commons

Y S Sun,

Li-Yuan Zhang

Allergy medicine., Journal Year: 2025, Volume and Issue: unknown, P. 100036 - 100036

Published: Feb. 1, 2025

Language: Английский

Citations

0
Systemic barrier dysfunction in type 2 inflammation diseases: perspective in the skin, airways, and gastrointestinal tract DOI Creative Commons
Juan Meng, Hao Xiao, Feng Xu

et al.

Immunologic Research, Journal Year: 2025, Volume and Issue: 73(1)

Published: March 11, 2025

The epithelial barrier in different organs is the first line of defense against environmental insults and allergens, with type 2 immunity serving as a protective function. Genetic factors, biological chemical from surrounding environment altered regulate homeostasis through disruption tight junction proteins or dilated intercellular spaces. Recent studies suggest that dysfunction contributes to pathologic alteration diseases immune dysregulation including (but not limited to) atopic dermatitis, prurigo nodularis, asthma, chronic rhinosinusitis nasal polyps, eosinophilic esophagitis. In this review, we summarized current understanding its interaction inflammation across organs, discussed role pathogenesis inflammation. addition, recent progresses emerging restorative therapies are reviewed.

Language: Английский

Citations

0
The role of yes‐associated protein in nasal inflammatory diseases DOI Creative Commons
Bing Zhong, Yu Zhao

Eye & ENT Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Abstract Yes‐associated protein (YAP), a pivotal of the Hippo signaling pathway, plays crucial role in regulating cell proliferation and differentiation. Emerging evidence highlights its significance respiratory inflammatory disorders, including chronic rhinosinusitis, allergic rhinitis. This review delves into impact YAP on individuals affected by these ailments, with specific focus it nasal mucosal epithelial cells. We further explore interplay between mediators, outlining pathological mechanisms through which contributes to tissue restructuring contexts. Despite advancements, gaps persist understanding YAP's broader clinical applications. Future research directions are proposed this article bridge knowledge gaps.

Language: Английский

Citations

0
Identification of DIO2 as a Molecular Therapeutic Target for Depression in Chronic Rhinosinusitis: A Comprehensive Bioinformatics and Experimental Study DOI
Hao Lv, Peiqiang Liu, Yunfei Wang

et al.

Biochemical Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

Language: Английский

Citations

0
The characterization and validation of regulated cell death-related genes in chronic rhinosinusitis with nasal polyps DOI
Hongxia Li, Fei Jing, Wei Xu

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 154, P. 114509 - 114509

Published: March 31, 2025

Language: Английский

Citations

0