Tuning of liver circadian transcriptome rhythms by thyroid hormone state in male mice

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Янв. 5, 2024

Abstract Thyroid hormones (THs) are important regulators of systemic energy metabolism. In the liver, they stimulate lipid and cholesterol turnover increase bioavailability. It is still unknown how TH state interacts with circadian clock, another regulator We addressed this question using a mouse model hypothyroidism performed analyses. Low levels decreased locomotor activity, food intake, body temperature mostly in active phase. Concurrently, liver transcriptome profiling showed only subtle effects compared to elevated conditions. Comparative revealed alterations mesor, amplitude, phase transcript livers low-TH mice. Genes associated uptake, biosynthesis, bile acid secretion reduced mesor. Increased serum were identified, respectively. Combining data from low- high-TH conditions allowed identification 516 genes mesor changes as molecular markers state. explored these created an expression panel that assesses time-of-day dependent manner. Our findings suggest has low action under physiological Circadian reveals potential

Язык: Английский

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Sexual dimorphism of circadian liver transcriptome

iScience, Год журнала: 2024, Номер 27(4), С. 109483 - 109483

Опубликована: Март 12, 2024

Sexual dimorphism affects various aspects of physiology, metabolism and longevity. Circadian clock is a master regulator metabolism. Anti-aging dietary interventions reprogram circadian transcriptome in the liver other tissues, but little known about sexual transcriptome. We compared transcriptomes male female mice on

Язык: Английский

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Cognitive Impairment and Dementia: Gaining Insight through Circadian Clock Gene Pathways

Biomolecules, Год журнала: 2021, Номер 11(7), С. 1002 - 1002

Опубликована: Июль 9, 2021

Neurodegenerative disorders affect fifteen percent of the world's population and pose a significant financial burden to all nations. Cognitive impairment is seventh leading cause death throughout globe. Given enormous challenges treat cognitive disorders, such as Alzheimer's disease, inability markedly limit disease progression, circadian clock gene pathways offer an exciting strategy address loss. Alterations in genes can result age-related motor deficits, treatment regimens with neurodegenerative lead onset progression dementia. Interestingly, hold intricate relationship autophagy, mechanistic target rapamycin (mTOR), silent mating type information regulation 2 homolog 1

Язык: Английский

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Aging, circadian disruption and neurodegeneration: Interesting interplay

Experimental Gerontology, Год журнала: 2022, Номер 172, С. 112076 - 112076

Опубликована: Дек. 24, 2022

The circadian system is an intricate molecular network of coordinating clocks that organize the internal synchrony organism in response to environment. These rhythms are maintained by genetically programmed positive and negative auto-regulated transcriptional translational feedback loops sustain 24-hour oscillations mRNA protein components endogenous clock. Since inter intracellular activity central pacemaker appears reduce with aging, interaction between clock aging continues elude our understanding. In this review article, we discuss at level how adversely affects functioning rodents humans. natural decline melatonin levels strongly contributes dysregulation resulting development neurological anomalies. Additionally, inappropriate environmental conditions such as Artificial Light Night (ALAN) can cause disruption or chronodisruption (CD) which result a variety pathological diseases, including premature aging. Furthermore, summarize recent evidence suggesting CD may also be predisposing factor for age-related neurodegenerative diseases (NDDs) Alzheimer's disease (AD), Parkinson's (PD), Huntington's (HD), although more investigation required prove link. Finally, certain chrono-enhancement approaches have been offered intervention strategies prevent, alleviate, mitigate impacts CD. This thus aims bring together advancements chronobiology process, well its role NDDs.

Язык: Английский

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Social synchronization of circadian rhythms with a focus on honeybees

Philosophical Transactions of the Royal Society B Biological Sciences, Год журнала: 2021, Номер 376(1835)

Опубликована: Авг. 23, 2021

Many animals benefit from synchronizing their daily activities with conspecifics. In this hybrid paper, we first review recent literature supporting and extending earlier evidence for a lack of clear relationship between the level sociality social entrainment circadian rhythms. Social is specifically potent in that live constant environments which some or all individuals do not experience ambient day-night cycles. We next focus on highly honeybees there good cues entrain clocks nest bees can override influence conflicting light-dark The current understanding synchronization consistent self-organization models surrogates forager activity, such as substrate-borne vibrations colony volatiles, dwelling dark cavity nest. Finally, present original findings showing effective even an array individually caged callow placed same substrate improved connected cages. These reveal remarkable sensitivity to time-giving show attenuated rhythms (weak oscillators) nevertheless be socially synchronized common phase activity. This article part theme issue ‘Synchrony rhythm interaction: brain behavioural ecology’.

Язык: Английский

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Ventilator-induced Lung Injury Is Modulated by the Circadian Clock

American Journal of Respiratory and Critical Care Medicine, Год журнала: 2022, Номер 207(11), С. 1464 - 1474

Опубликована: Дек. 8, 2022

Rationale: Mechanical ventilation (MV) is life-saving but may evoke ventilator-induced lung injury (VILI). Objectives: To explore how the circadian clock modulates severity of murine VILI via core component BMAL1 (basic helix-loop-helix ARNT like 1) in myeloid cells. Methods: Myeloid cell BMAL1-deficient (LysM (lysozyme 2 promoter/enhancer driving cre recombinase expression)Bmal1-/-) or wild-type control (LysMBmal1+/+) mice were subjected to 4 hours MV (34 ml/kg body weight) induce injury. Ventilation was initiated at dawn dusk complete darkness (circadian time [CT] 0 CT12) determine diurnal and effects. Lung quantified by function, pulmonary permeability, blood gas analysis, neutrophil recruitment, inflammatory markers, histology. Neutrophil activation oxidative burst analyzed ex vivo. Measurements Main Results: In experiments, ventilated exhibited higher permeability recruitment compared with dusk. Experiments CT showed deterioration worsening oxygenation, increased mortality CT0 CT12. Wild-type neutrophils isolated reactive oxygen species production dusk, whereas these day-night differences dampened LysMBmal1-/- neutrophils. mice, variations VILI-induced reduced LysMBmal1+/+ mice. Conclusions: Inflammatory response barrier dysfunction upon exhibit variations, regulated clock. are less susceptible ventilation-induced pathology lack variation Our data suggest that internal cells an important modulator VILI.

Язык: Английский

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Secretion of glucagon, GLP-1 and GIP may be affected by circadian rhythm in healthy males

BMC Endocrine Disorders, Год журнала: 2024, Номер 24(1)

Опубликована: Март 14, 2024

Abstract Background Glucagon is secreted from pancreatic alpha cells in response to low blood glucose and increases hepatic production. Furthermore, glucagon enhances protein lipid metabolism during a mixed meal. Glucagon-like peptide-1 (GLP-1) glucose-dependent insulinotropic polypeptide (GIP) are gut endocrine meals control homeostasis by potentiating insulin secretion inhibiting food intake. Both intake have been reported be affected circadian rhythms vice versa. In this study, we investigated whether the of glucagon, GLP-1 GIP was rhythms. Methods A total 24 healthy men with regular sleep schedules were examined for h at hospital ward 15 wakefulness 9 sleep. Food standardized, samples obtained every third hour. Plasma concentrations measured, data analyzed rhythmometric statistical methods. Available on plasma C-peptide also included. Results GLP-1, GIP, fluctuated diurnal 24-h rhythm, highest levels day lowest night: ( p < 0.0001, peak time 18:26 h), 17:28 18:01 17.59 23:26 h). As expected, found significant correlations between but did not find GIP. Conclusions Our results demonstrate that under meal conditions similar many free-living individuals, observed higher daytime evening than overnight. These findings underpin disturbed rhythm as potential risk factor diabetes obesity. Trial registration ClinicalTrials.gov Identifier: NCT06166368. Registered 12 December 2023.

Язык: Английский

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Using routinely collected clinical data for circadian medicine: A review of opportunities and challenges

PLOS Digital Health, Год журнала: 2024, Номер 3(5), С. e0000511 - e0000511

Опубликована: Май 23, 2024

A wealth of data is available from electronic health records (EHR) that are collected as part routine clinical care in hospitals worldwide. These rich, longitudinal offer an attractive object study for the field circadian medicine, which aims to translate knowledge rhythms improve patient health. This narrative review discuss opportunities EHR studies highlight methodological challenges, and provide recommendations using these advance field. In existing literature, we find real-world settings have potential shed light on key questions including how 24-hour features associated with—or even predictive of—health outcomes, whether effect medication or other activities depend time day, physiology may influence reference ranges sampling protocols. However, optimal use medicine requires careful consideration limitations sources bias inherent sources. particular, day influences almost every interaction between a healthcare system, creating operational patterns little nothing do with biology. Addressing challenges could help expand evidence base medicine.

Язык: Английский

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Dysregulation of the molecular clock by blood-borne factors in Alzheimer’s disease patients

Journal of Neurology, Год журнала: 2025, Номер 272(2)

Опубликована: Янв. 15, 2025

Язык: Английский

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Investigating the circadian rhythm signaling pathway in HTLV-1 pathogenesis using Boolean analysis

Virus Research, Год журнала: 2025, Номер 353, С. 199539 - 199539

Опубликована: Фев. 12, 2025

The Human T-cell lymphotropic virus type 1 (HTLV-1), an oncogenic belonging to the Deltaretrovirus genus, expresses various proteins, including Tax and HBZ, which can affect many cellular pathways. In this study, we have investigated role of circadian rhythm signaling pathway, a key regulator human health, in pathogenesis HTLV-1 using Boolean Network analysis laboratory methods. After extensive search analyzed relationships between genes pathway R programming language BoolNet package. Subsequently, examined impact viral proteins on clock genes. Finally, identified three genes, PER2, CRY1, DEC1, as main checkpoints from attractors obtained. These two were quantitatively assessed groups individuals, ten asymptomatic carriers infected with healthy individuals qRT-PCR method. Our results showed that expression level PER2 DEC1 was significantly higher compared control group. Also, recorded positive correlations CRY1 negative HBZ DEC1. suggested carriers, might try induce chronic infection by escaping immune system due alteration We also detected promising could therapeutic or diagnostic value these individuals. However, possibility requires further research different periods, (e.g., ATLL HAM/TSP), examining more significant number

Язык: Английский

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