Trends in incidence, mortality, and survival of cutaneous malignant melanoma over three decades: a population-based study in Southern Spain DOI
Teresa Ródenas‐Herranz, Miguel Rodríguez‐Barranco, Dafina Petrova

и другие.

Clinical and Experimental Dermatology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 22, 2024

Abstract Background Cutaneous malignant melanoma (CMM) represents a global public health problem. Epidemiological studies about CMM trends tend to focus on single indicators or lack information tumour characteristics that can help gain more thorough understanding of epidemiology. Objectives To fill this gap, we studied in incidence, mortality and survival over three decades considered sex, age characteristics. Methods Data were obtained for all patients with new diagnosis during 1985–2017 from the population-based cancer registry Granada (Southern Spain) deaths owing Ministry Health Spanish government. Incidence, estimates according group, anatomical site, histological type, Breslow index Clark level. Observed net calculated 1, 3 5 years using Kaplan–Meier Pohar–Perme methods, respectively. Log-linear jointpoint regression was used assess temporal age-standardized rates incidence mortality. Results Between 1985 2017, 2446 aged ≥ 15 newly diagnosed CMM. There significant increase both males females (annual percentage change 4.4% 3.7%, respectively), mainly superficial spreading nodular melanomas, pronounced among those < 1 mm index. Mortality increased, driven by increases individuals 65 old. Nodular had worst prognosis, 5-year 62.7% period 2008–2017 compared > 90% other subtypes. Overall improved 78.3% 1985–1997 88.6% 2008–2017, clear trend Conclusions The early stages Southern Spain has increased recent decades. This been accompanied noticeable improvements survival, especially younger groups, suggesting potential effectiveness prevention strategies treatment regimens.

Язык: Английский

Sex differences in survival from melanoma of the skin: the role of age, anatomic location and stage at diagnosis: a CONCORD-3 study in 59 countries DOI Creative Commons
V Di Carlo, Andrea Eberle, Charles Stiller

и другие.

European Journal of Cancer, Год журнала: 2025, Номер 217, С. 115213 - 115213

Опубликована: Янв. 13, 2025

Язык: Английский

Процитировано

1
Incidence and survival of patients with melanoma in Colombia DOI Creative Commons
Henry Oliveros,

Juliana Usta Stavoli,

Nadia Juliana Proaños

и другие.

Cancer Epidemiology, Год журнала: 2025, Номер 96, С. 102784 - 102784

Опубликована: Март 6, 2025

Язык: Английский

Процитировано

1
Heterogeneous pathogenesis of melanoma: BRAF mutations and beyond DOI Creative Commons
Maria Colombino, Milena Casula, Panagiotis Paliogiannis

и другие.

Critical Reviews in Oncology/Hematology, Год журнала: 2024, Номер 201, С. 104435 - 104435

Опубликована: Июль 6, 2024

Melanoma pathogenesis, conventionally perceived as a linear accumulation of molecular changes, discloses substantial heterogeneity driven by non-linear biological processes, including the direct transformation melanocyte stem cells. This manifests in diverse phenotypes and developmental states, influencing variable responses to treatments. Unveiling aberrant mechanisms steering melanoma initiation, progression, metastasis is imperative. Beyond mutations oncogenic tumor suppressor genes, involvement distinct pathways assumes pivotal role pathogenesis. Ultraviolet (UV) radiations, principal factor etiology, categorizes melanomas based on cumulative sun damage (CSD). The genomic landscape lesions correlates with UV exposure, impacting mutational load spectrum mutations. World Health Organization's 2018 classification underscores interplay between exposure characteristics, distinguishing associated CSD from those unrelated CSD. elucidates features such burden copy number alterations different subtypes. significance mutated BRAF gene its pathway, notably BRAFV600 variants, paramount. mutations, prevalent across cancer types, present therapeutic avenues, clinical trials validating efficacy targeted therapies immunotherapy. Additional driver oncogenes further characterize specific pathways, behavior. While histopathological examination remains pivotal, challenges persist molecularly classifying melanocytic tumors. In this review, we went through all characterization that aid discriminating common ambiguous lesions. Integration highly sensitive diagnostic tests into workflow becomes indispensable, particularly instances where histology alone fails achieve conclusive diagnosis. A algorithm inferred various studies here proposed.

Язык: Английский

Процитировано

7
Infant and young child feeding DOI Open Access
Luca Lorenzoni,

Yoshiaki Hori,

Gabriel Paolantonio

и другие.

Health at a glance. Asia/Pacific, Год журнала: 2022, Номер unknown

Опубликована: Дек. 9, 2022

Optimal feeding practices of infants can increase their chances survival. They play an important role for healthy growth and development, decrease rates stunting obesity stimulate intellectual development (UNICEF, 2019[1]).

Язык: Английский

Процитировано

27
Survival in melanoma in the nordic countries into the era of targeted and immunological therapies DOI Creative Commons
Filip Tichánek, Asta Försti, Akseli Hemminki

и другие.

European Journal of Cancer, Год журнала: 2023, Номер 186, С. 133 - 141

Опубликована: Март 24, 2023

Язык: Английский

Процитировано

15
A Review of Recent Advances in Computer-Aided Detection Methods Using Hyperspectral Imaging Engineering to Detect Skin Cancer DOI Open Access

Hung‐Yi Huang,

Yu‐Ping Hsiao, Riya Karmakar

и другие.

Cancers, Год журнала: 2023, Номер 15(23), С. 5634 - 5634

Опубликована: Ноя. 29, 2023

Skin cancer, a malignant neoplasm originating from skin cell types including keratinocytes, melanocytes, and sweat glands, comprises three primary forms: basal carcinoma (BCC), squamous (SCC), melanoma (MM). BCC SCC, while constituting the most prevalent categories of are generally considered less aggressive compared to MM. Notably, MM possesses greater capacity for invasiveness, enabling infiltration into adjacent tissues dissemination via both circulatory lymphatic systems. Risk factors associated with cancer encompass ultraviolet (UV) radiation exposure, fair complexion, history sunburn incidents, genetic predisposition, immunosuppressive conditions, exposure environmental carcinogens. Early detection is paramount importance optimize treatment outcomes preclude progression disease, either locally or distant sites. In pursuit this objective, numerous computer-aided diagnosis (CAD) systems have been developed. Hyperspectral imaging (HSI), distinguished by its capture information spanning electromagnetic spectrum, surpasses conventional RGB imaging, which relies solely on color channels. Consequently, study offers comprehensive exploration recent CAD investigations pertaining utilizing HSI, emphasizing diagnostic performance parameters such as sensitivity specificity.

Язык: Английский

Процитировано

15
Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma: Outcomes in histopathologic subgroups from the randomized, double-blind, phase 3 KEYNOTE-716 trial DOI Creative Commons
Dirk Schadendorf, Jason J. Luke, Paolo A. Ascierto

и другие.

Journal for ImmunoTherapy of Cancer, Год журнала: 2024, Номер 12(3), С. e007501 - e007501

Опубликована: Март 1, 2024

Background Adjuvant pembrolizumab significantly improved recurrence-free survival (RFS) and distant metastasis-free (DMFS) versus placebo in the phase 3 KEYNOTE-716 study of resected stage IIB or IIC melanoma. At prespecified third interim analysis (data cut-off, January 4, 2022), HR for RFS overall population was 0.64 (95% CI, 0.50 to 0.84) DMFS 0.47 0.88). We present a post hoc efficacy by subtypes defined histopathologic characteristics. Methods Patients aged ≥12 years with newly diagnosed, melanoma were randomly assigned (1:1) 200 mg every weeks (2 mg/kg up pediatric patients) placebo. The primary end point per investigator review; review secondary. Subgroups interest subtype (nodular vs non-nodular), tumor thickness (≤4 mm >4 mm), presence ulceration (yes no), mitotic rate (<5 2 (median) ≥5 ), tumor-infiltrating lymphocytes (TILs; absent present). Results Between September 23, 2018, November 2020, 976 patients (n=487) (n=489). Median follow-up 27.4 months (range, 14.0–39.4). CI) 0.54 (0.37 0.79) nodular 0.77 (0.53 1.11) non-nodular melanoma; 0.57 0.89) ≤4 0.69 (0.50 0.96) mm; 0.66 (0.32 1.03) no ulceration; (0.35 0.92) <5 (0.40 0.80) ; 0.89 (0.52 1.54) TILs 0.51 (0.34 0.76) present. results similar. In Cox multivariate analysis, treatment arm, thickness, significant independent factors RFS, arm DMFS. Conclusions this benefit largely consistent regardless These support use adjuvant Trial registration number ClinicalTrials.gov, NCT03553836 .

Язык: Английский

Процитировано

6
European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics - Update 2024 DOI Creative Commons
Claus Garbe, Teresa Amaral, Ketty Peris

и другие.

European Journal of Cancer, Год журнала: 2024, Номер 215, С. 115152 - 115152

Опубликована: Ноя. 29, 2024

Язык: Английский

Процитировано

5
Primary Undifferentiated/Dedifferentiated Cutaneous Melanomas—A Review on Histological, Immunohistochemical, and Molecular Features with Emphasis on Prognosis and Treatment DOI Open Access
Dana Antonia Țăpoi, Ancuța-Augustina Gheorghișan-Gălățeanu, Adrian Dumitru

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(12), С. 9985 - 9985

Опубликована: Июнь 10, 2023

Diagnosing cutaneous melanoma is usually straightforward based on these malignancies' histopathological and immunohistochemical features. Nevertheless, melanomas can imitate various other neoplasms, sometimes lacking the expression of conventional melanocytic markers expressing non-melanocytic ones. Furthermore, divergent differentiation more often encountered in metastatic still poorly described primary melanomas, little known about patients' prognosis therapeutic approach. Therefore, we reviewed literature undifferentiated/dedifferentiated discuss histological, immunohistochemical, molecular profiles to understand peculiar lesions better improve their diagnostic algorithm. In addition this, also how different genetic mutations may influence become potential targets.

Язык: Английский

Процитировано

11
Acral melanoma: new insights into the immune and genomic landscape DOI Creative Commons
Larissa Anastácio da Costa Carvalho, Flavia C. Aguiar, Keiran S.M. Smalley

и другие.

Neoplasia, Год журнала: 2023, Номер 46, С. 100947 - 100947

Опубликована: Окт. 31, 2023

Acral melanoma is a rare subtype of that arises on the non-hair bearing skin nail bed, palms hand and soles feet. It unique among melanomas in not being linked to ultraviolet radiation (UVR) exposure from sun, and, as such, its incidence similar across populations who are Asian, Hispanic, African European origin. Although research into acral has lagged behind sun-exposed cutaneous melanoma, recent studies have begun address genetics immune features melanoma. In this review we will discuss latest progress understanding biology different ethnic outline how these new discoveries can help guide therapeutic management tumor.

Язык: Английский

Процитировано

11