Health at a glance. Asia/Pacific, Journal Year: 2022, Volume and Issue: unknown
Published: Dec. 9, 2022
Pregnancy and childbearing, whilst offering women opportunities for personal development fulfilment, also present inherent risks. Maternal mortality is an important indicator of a woman's health status. The Sustainable Development Goals set target reducing the maternal ratio to less than 70 deaths per 100 000 live births by 2030.
Language: Английский
European Journal of Cancer, Journal Year: 2025, Volume and Issue: 217, P. 115213 - 115213
Published: Jan. 13, 2025
Language: Английский
Citations
1
Cancer Epidemiology, Journal Year: 2025, Volume and Issue: 96, P. 102784 - 102784
Published: March 6, 2025
Language: Английский
Citations
1
Journal for ImmunoTherapy of Cancer, Journal Year: 2024, Volume and Issue: 12(3), P. e007501 - e007501
Published: March 1, 2024
Background Adjuvant pembrolizumab significantly improved recurrence-free survival (RFS) and distant metastasis-free (DMFS) versus placebo in the phase 3 KEYNOTE-716 study of resected stage IIB or IIC melanoma. At prespecified third interim analysis (data cut-off, January 4, 2022), HR for RFS overall population was 0.64 (95% CI, 0.50 to 0.84) DMFS 0.47 0.88). We present a post hoc efficacy by subtypes defined histopathologic characteristics. Methods Patients aged ≥12 years with newly diagnosed, melanoma were randomly assigned (1:1) 200 mg every weeks (2 mg/kg up pediatric patients) placebo. The primary end point per investigator review; review secondary. Subgroups interest subtype (nodular vs non-nodular), tumor thickness (≤4 mm >4 mm), presence ulceration (yes no), mitotic rate (<5 2 (median) ≥5 ), tumor-infiltrating lymphocytes (TILs; absent present). Results Between September 23, 2018, November 2020, 976 patients (n=487) (n=489). Median follow-up 27.4 months (range, 14.0–39.4). CI) 0.54 (0.37 0.79) nodular 0.77 (0.53 1.11) non-nodular melanoma; 0.57 0.89) ≤4 0.69 (0.50 0.96) mm; 0.66 (0.32 1.03) no ulceration; (0.35 0.92) <5 (0.40 0.80) ; 0.89 (0.52 1.54) TILs 0.51 (0.34 0.76) present. results similar. In Cox multivariate analysis, treatment arm, thickness, significant independent factors RFS, arm DMFS. Conclusions this benefit largely consistent regardless These support use adjuvant Trial registration number ClinicalTrials.gov, NCT03553836 .
Language: Английский
Citations
6
Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 201, P. 104435 - 104435
Published: July 6, 2024
Melanoma pathogenesis, conventionally perceived as a linear accumulation of molecular changes, discloses substantial heterogeneity driven by non-linear biological processes, including the direct transformation melanocyte stem cells. This manifests in diverse phenotypes and developmental states, influencing variable responses to treatments. Unveiling aberrant mechanisms steering melanoma initiation, progression, metastasis is imperative. Beyond mutations oncogenic tumor suppressor genes, involvement distinct pathways assumes pivotal role pathogenesis. Ultraviolet (UV) radiations, principal factor etiology, categorizes melanomas based on cumulative sun damage (CSD). The genomic landscape lesions correlates with UV exposure, impacting mutational load spectrum mutations. World Health Organization's 2018 classification underscores interplay between exposure characteristics, distinguishing associated CSD from those unrelated CSD. elucidates features such burden copy number alterations different subtypes. significance mutated BRAF gene its pathway, notably BRAFV600 variants, paramount. mutations, prevalent across cancer types, present therapeutic avenues, clinical trials validating efficacy targeted therapies immunotherapy. Additional driver oncogenes further characterize specific pathways, behavior. While histopathological examination remains pivotal, challenges persist molecularly classifying melanocytic tumors. In this review, we went through all characterization that aid discriminating common ambiguous lesions. Integration highly sensitive diagnostic tests into workflow becomes indispensable, particularly instances where histology alone fails achieve conclusive diagnosis. A algorithm inferred various studies here proposed.
Language: Английский
Citations
6
Health at a glance. Asia/Pacific, Journal Year: 2022, Volume and Issue: unknown
Published: Dec. 9, 2022
Optimal feeding practices of infants can increase their chances survival. They play an important role for healthy growth and development, decrease rates stunting obesity stimulate intellectual development (UNICEF, 2019[1]).
Language: Английский
Citations
26
European Journal of Cancer, Journal Year: 2023, Volume and Issue: 186, P. 133 - 141
Published: March 24, 2023
Language: Английский
Citations
14
Cancers, Journal Year: 2023, Volume and Issue: 15(23), P. 5634 - 5634
Published: Nov. 29, 2023
Skin cancer, a malignant neoplasm originating from skin cell types including keratinocytes, melanocytes, and sweat glands, comprises three primary forms: basal carcinoma (BCC), squamous (SCC), melanoma (MM). BCC SCC, while constituting the most prevalent categories of are generally considered less aggressive compared to MM. Notably, MM possesses greater capacity for invasiveness, enabling infiltration into adjacent tissues dissemination via both circulatory lymphatic systems. Risk factors associated with cancer encompass ultraviolet (UV) radiation exposure, fair complexion, history sunburn incidents, genetic predisposition, immunosuppressive conditions, exposure environmental carcinogens. Early detection is paramount importance optimize treatment outcomes preclude progression disease, either locally or distant sites. In pursuit this objective, numerous computer-aided diagnosis (CAD) systems have been developed. Hyperspectral imaging (HSI), distinguished by its capture information spanning electromagnetic spectrum, surpasses conventional RGB imaging, which relies solely on color channels. Consequently, study offers comprehensive exploration recent CAD investigations pertaining utilizing HSI, emphasizing diagnostic performance parameters such as sensitivity specificity.
Language: Английский
Citations
13
Neoplasia, Journal Year: 2023, Volume and Issue: 46, P. 100947 - 100947
Published: Oct. 31, 2023
Acral melanoma is a rare subtype of that arises on the non-hair bearing skin nail bed, palms hand and soles feet. It unique among melanomas in not being linked to ultraviolet radiation (UVR) exposure from sun, and, as such, its incidence similar across populations who are Asian, Hispanic, African European origin. Although research into acral has lagged behind sun-exposed cutaneous melanoma, recent studies have begun address genetics immune features melanoma. In this review we will discuss latest progress understanding biology different ethnic outline how these new discoveries can help guide therapeutic management tumor.
Language: Английский
Citations
11
European Journal of Cancer, Journal Year: 2024, Volume and Issue: 215, P. 115152 - 115152
Published: Nov. 29, 2024
Language: Английский
Citations
4
Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 17, 2025
To establish a predictive model for prognosis of cutaneous melanoma using machine learning algorithms in large sample data. A retrospective analysis patients diagnosed with the SEER database from 2010 to 2015 was performed 12 different algorithms, total 97 algorithm combinations, screen variables associated and build models. 24,457 cases were collected this study, 8,441 finally included. Among them, 5908 training set 2533 test set. The results study show that StepCox[both] + RSF is best model. variable features screened by Sex, Age, Marital, T stage, N Ulcer, Site, Histologic, Surgery, Chemotherapy, Bone metastasis, Liver metastasis Lung metastasis. We have developed good accuracy combination database.
Language: Английский
Citations
0